265
147755989012055111
ANEES5776100243148296400504608
RAHMAN12416100243116264400580728876
CHERATTA21736100243156292396512660744828976
Department577849014684161240319358394506583655691
of1302849014677110
Biochemistry144684901466998175252324401513542595631669739
College5771009014694170199228305384461
of10711009014677111
Medicine121510090146108185264293370399471548
and17961009014679151231
Health20601009014682159238267303375
Sciences24681009014663139168245317394471523
Title438180601344673106132202
A14181727018873
study1513172701884373134189238
on17791727018855116
sanguinarine1922172701884398159214275306367422465496557606
as2555172701885598
an26801727018855117
antileukemic28241727018855116147177208257318373422507538587
agent–34381727018855110159220251306
involvement3771172701883192141196227275324410459520550
of4349172701885592
reactive4468172701884392147195226257305354
oxygen48501727018855110159214262324
species-ceramide-Akt1418186701884398147195226275318354403452495550635666721770806880935965
apoptotic24111867018855110165220250305336367415
signaling2854186701884373128189244275306367422
pathway33031867018855110141202275330379
Faculty4382101013453125196262288321385
Advisor8542101013481154215242290361396
Prof.14182098016061100159194220
Sehamuddin16722098016061119181239331392453514539601
Galadari23072098016073131156214275333372397
Defense4382319013477147178249315363433
Date9022319013477150183253
0314182316016060120
March15732316016084142182232293
201619012316016060120180240
Abstract4383975013481154202235271343414447
Dysregulation14182520016075129178218275336398423481517543602664
of2106252001606095
apoptosis22252520016058119179239276336385410459
is2719252001601564
a28082520016057
prime28902520016061100125218276
hallmark31902520016062119144170262320360414
of3629252001606095
leukemia.3758252001601573135189246339364422455
Therefore,42372520016065126184223281316375414471505
drugs47662520016061101162223272
which50632520016081143168218280
restore5377252001603087136173233272330
the5741252001602789146
sensitivity5922252001603997158207233270295350375412465
of6412252001606095
leukemic1418267001602583144199256348374424
cells18642670016050108133159208
to2106267001602483
apoptotic22112670016057118178239276335372397448
stimuli2680267001604986111203265290315
are3016267001605898155
promising31922670016061101160252277326352413474
candidates36872670016051108170231256317374411469518
in4239267001601274
the4347267001602385143
treatment4524267001602463121178215308365427463
of5009267001605994
leukemia.5138267001601270131186243335360418451
The56102670016065126184
main58152670016092150175237
objective60732670016059120151209260297322377434
of1418282001606095
this1547282001603092117166
dissertation1741282001606086135184242281318376412438497559
was23282820016081138187
to2550282001603089
examine26672820016058112170263288349407
the3108282001603192150
antileukemic32862820016057119155181206264325380437529554605
effect3919282001605893127184234271
of4218282001606095
sanguinarine,43472820016043100162223284309371428468493554612646
in5027282001601880
vitro,5141282001604873110150209241
and54102820016057119180
to5624282001603090
further5748282001602989128165227284324
examine61002820016058112170262288349407
the1418297001603798156
signaling1608297001605581141203261286311372433
mechanisms20812970016093151201263320382407456548597
that27132970016042104162198
may29522970016092150204
be31902970016067125
involved.3349297001603193146205230285342403436
This38202970016070131156205
study4060297001605592153214268
demonstrates43632970016067124217277338387424463519556614663
that50602970016043104162199
in5293297001603293
human54202970016067129221279340
leukemic5795297001603189150205262354379430
cells,62592970016057115140165215248
sanguinarine14183120016049107168229290316377435474500561619
activates20713120016053104140165220276313371420
a25253120016053
caspase-dependent26123120016046104153214272321378418479537598656717778836897934
apoptotic35803120016053114174235271331368393444
cell40583120016046104129155
death42423120016061119177213275
pathway45463120016061119156217298355409
that4989312001603294151188
is5211312001602170
characterized53153120016046107165205261311348406446471520577638
by59833120016060115
reactive6132312001603592150201238263318375
oxygen14183270016060113168228286348
species-dependent18003270016056117174225250308357397458516577635696757815876913
ceramide27473270016058116155211304329390448
generation,32293270016068125187245284340377402462523557
and38203270016064126187
subsequent40413270016056117178227285346407465526563
inhibition4639327001603293154180240266302328387449
of51223270016067102
Akt52583270016073128164
signaling5457327001605681142203261286311372433
pathway.59253270016067125162223304361415439
In63983270016048109
addition,14183420016058119179205241267326388421
sanguinarine18613420016050107169229291316377435475500561619
also2503342001605782132191
induces2729342001601374135196247305354
reactive3118342001602784142193230255310367
oxygen35073420016060114168229286348
species-dependent38773420016049110168219244302351391452509570628690750808870906
glutathione4806342001606186147184242279340365425486544
depletion53723420016061119180205263300325385446
and58413420016057119179
activation60433420016058108145170225281317343402464
of1418357001606095
extracellular15473570016073127164204260310368393419480506563603
signal-regulated2184357001606489150212269295334374431492554579636673731792
kinase12/.3010357001607095157214263321381441483517
Moreover,356135700160100160199257316370427467486
inhibition40813570016040101163188249274311336396457
of45723570016075110
reactive47163570016055112170221258283338395
oxygen51453570016075128183243301363
species55423570016064125183233259316365
generation,59423570016076134195253292348385410470531565
using14183720016061110136197258
reactive17103720016043100158208245270325382
oxygen21273720016062116170231288350
species25113720016052113171221247305354
scavengers28993720016052103160215272333394452491540
and34743720016060122182
antioxidants,36913720016060122158184243297322383441502539588621
significantly4347372001605176137199224253283333391452489514569
abrogates49503720016061122161221281339376434483
sanguinarine-induced546737200160521101712322933193804384775035646226626877488098709219791040
ceramide14183870016051109148204297322383440
generation,18933870016089147209267306362399424484545578
Akt25063870016095149186
dephosphorylation,27273870016089147208269329378439500560600654680737774799859920954
extracellular37153870016087141178218274324382407433494519577617
signal-regulated43663870016078103164225283308348388445506567592650687745806
kinase12/52063870016084109170228277335395455497
activation,57383870016086137174199254309346371431492526
and62983870016087148209
apoptosis.14184020016058119178239276336385410459492
Sanguinarine-induced194540200160591171792393013263874454855105716296696947568168789299861047
ceramide30274020016049106146202294320380438
generation35004020016059117178236276332368394453515
is4049402001602473
mediated41554020016092150211236294331388449
via4639402001605378136
reactive4809402001603896153204241266321378
oxygen52214020016059112167227285347
species-dependent56024020016048108166217242300349389450508568626688749806868905
activation14184170016058108145170225281318343403464
of1916417001605893
acid20434170016056107132193
sphingomyelinase22704170016047108170195256317377469523580605630692749798856
in3161417001602384
Jurkat32804170016043105144199257294
cells36084170016049107132157206
and38494170016056117178
inhibition4061417001602385146171232257294319379440
of4536417001605792
acid46634170016056106131192
ceramidase48904170016048106146202294319380438487545
and54694170016056117178
glucosylceramide5682417001605884145196255304359384435493533589681706767825
synthase14184320016049104165202263321370428
in18804320016042103
both20184320016076136173234
Jurkat22864320016062124163218276313
and26334320016074135196
Molt-4286343200160101161186223261321
cells.32184320016067125150176225258
Furthermore,35104320016074135175211273331370463522562619653
the41974320016053114172
involvement44044320016041102156215240295352444502563600
of50394320016075110
ceramide-activated51844320016066124164220312338398456496553604640666720776813871931
protein61504320016077116176212270295357
phosphatase-114184470016061122182231292353411448505555612652712
in2165447001602082
sanguinarine-induced228144700160441021642242863113724304704955566146546797408018639139711032
Akt33434470016066121157
dephosphorylation35304470016061119180241301350411472532571626651709746771831892
and44564470016053115176
apoptosis46664470016053114174234271331380405454
is5155447001602069
demonstrated.52544470016061119211271332381418458513550608669702
Altogether,5986447001606691128188249307343405463502521
this1418462001603798123172
study1625462001605794156216271
underscores19314620016070131192250289338389449488546595
the25604620016046107165
critical2759462001606099125162187237295320
role31144620016048107132190
for33394620016043102142
reactive35154620016048106163214251276331388
oxygen39374620016069122177237295357
species-ceramide-Akt432846200160581181762272523103593994505085476036967217828408809439981035
signaling5397462001605883144205263288313375435
pathway58674620016069127164225306363417
and63184620016067128189
reactive1418477101604097155205242267322379
oxygen18324771016060113168228286347
species-dependent22144771016049110168218244301351390451509570628689750808869906
extracellular31544771016059113150189245296354379405466491549589
signal-regulated3777477101604974135197254279319359416477538564621658716777
kinase12/4588477101605580142199249306366427469
activation50914771016058109145170225281318343403464
in5589477101602687
the5711477101603698156
antileukemic59014771016058119156181206264326380437530555606
action14184921016058108145170230292
of17444921016093128
sanguinarine.19074921016083140202263324349411468508533595652686
Understanding262749210160106167228286326375411469530591616678739
the34004921016071132190
molecular362449210160126186211269320381407464504
signaling41624921016083108169230288313339400461
mechanism465749210160126184235296354415441490582
of52734921016094129
sanguinarine-induced5436492101608314120226332535041146950853459565369371877984090295210101071
apoptosis14185071016058119178239276336385410459
undoubtedly19115071016088149210270331392428486547572627
should25735071016074136195257282343
have29505071016087145199256
a32415071016083
great33595071016086126183241278
impact36715071016051144205262313350
on40555071016086147
future42375071016060121158219259316
sanguinarine-based45875071016075133194255317342403461501526587645685746804853910971
antileukemic55935071016083145181206232289351406463555580631
drug62585071016087127188249
development.14185221016061119175232258318379472531593630664
Dissertation3971558017098132193255344389431524566599689773