391
1561965989012055111
Profiles3670599101205989154179203223288327
of4025599101206596
Doctorate41495991012075140205239304334403436501
Dissertations4678599101207595133172237267301369403423489550589
Research1493848013464134183253326361431497
Relevance2021848013464134161231293365431502572
and2624848013472138211
Potential2866848013461132165235301334361433460
Impact3356848013431135207280350383
Leukemia14931004014650102158208260344367419
is1943100401464186
the20601004014651107160
most225110040146102156201234
common25171004014664118202286340396
type29441004014651100156208
of31841004014672104
childhood33191004014664120143165221277331385440
cancer37911004014664116172218271307
in4129100401464197
most425710040146102156201234
parts45221004014673126162195240
of47931004014672104
the49291004014651107159
world.51201004014692146182205260290
The54421004014676132184
estimated1493115401465397131153238290323376431
leukemia-related1956115401462376132181233317340392429465517540592626678734
death27211154014656109161194250
in3003115401462379
200831131154014655110165219
was33641154014674126170
around3566115401465389143199254310
250,00039071154014655110164195249304358
globally4297115401465679133188241264287336
(«Global4665115401463996163185240295348370
Cancer50671154014660113169215267303
Facts54021154014653100147180225
and14931304014652108164
Figures,»1688130401465881137192228281325355413
2011).21321304014661116170225263294
The24571304014665121173
overall26621304014660110161197248271294
incidence2988130401462985131154209262318364416
of3436130401466092
leukemia3560130401462982137187239323346398
in3990130401462985
the4106130401464096148
developed42861304014662114164216239293348401456
countries47741304014652107162218251287310363408
has52131304014662115159
been54041304014662114167223
increasing1493145401462379125161213265310333389444
since1968145401465780136182235
the22341454014646102155
last2420145401463688133166
few2617145401464597171
decades.28191454014668121167219275327372402
According32521454014673119165219255310333389444
to37271454014646101
Heath38591454014680133185219274
Authority41651454014672128161217271307330364413
of4609145401466799
Abu47391454014673128184
Dhabi49541454014680136189244267
(HAAD),52521454014651118178238306345375
leukemia1493160401462375131181233317340392
is1916160401462064
the2012160401462985138
most21771604014684139183217
common2425160401464297181265319375
type2831160401463079134187
of3049160401465182
cancer3163160401464295150196249285
among34791604014649133188243299
males38051604014684137160212257
and40931604014649105160
the4284160401463086138
second4454160401464193139194249305
most47861604014684139183217
common5034160401464397181265319375
type5440160401463079134187
of1493175401465486
cancer16101754014653106162208261296
among19381754014659143198253309
females2278175401463990174227250302347
in2656175401463086
Abu27731754014667122178
Dhabi.29831754014674130183238261291
Phytochemicals14931984014655111160193248294349402486509555608630675
(non-nutritive21991984014666122176232268324380413449472505528578630
components28601984014674128212267322377430486519564
found34551984014659113168224279
in37661984014650106
plants)39031984014682105158213247291330
have42641984014683136185237
long45321984014650104160215
been47791984014682135187243
used50531984014684128181236
in53201984014651106
the54581984014660116169
treatment1493213401463369122174207291344400433
cancer.19582134014650103158205257293310
Currently,22992134014665121157193245301334357407428
over27582134014659108160196
60%29852134014659114212
of3228213401465990
the3350213401463893146
clinically352721340146517497152175221274297320370
approved39282134014657112167203257306358414
anticancer43732134014657113146169215267323369422458
agents48622134014657112165221254299
are5192213401465793145
either5368213401465780114170222258
directly1493228401465578114166212246269318
isolated1843228401461963118141193226279334
from2209228401462763117201
natural24372284014656108142198234284307
sources,2776228401464094150186232284329359
or3167228401465086
are3284228401464985137
modified34482284014684139194217243270323378
from3857228401462864117201
natural40862284014655108141197233284307
lead4424228401461972124179
molecules.46312284014684138161213260315338391435466
In5128228401463389
addition,52482284014648104159182215238293348379
a14932434014652
large1577243401463285121176228
number18372434014665121205260313349
of2217243401466496
promising23442434014665101155239262307330386441
candidates28162434014656108164219242298350384436481
are3328243401466298151
presently35102434014665101153198250306339362412
in3953243401463389
clinical4073243401465679102158181227279302
trial4406243401464379102155178
or46152434014664100
in4746243401463389
the4866243401464399152
development50492434014665118167219242296352436488544578
pipeline.1493258401465578133186209232288340371
Therefore,18952584014669125178214266298351387439470
natural23962584014667119153209245295318
products27462584014666102156211267313346391
are31682584014664100152
moving33522584014695149198221277332
to3716258401464498
be38462584014666119
one39962584014666121174
of4201258401466698
the43302584014645100153
most45142584014695150194228
successful47732584014656112158204256301345377432455
strategy5259258401465690126176210262318368
for1493273401463285121
the1645273401464499152
discovery1828273401466688133179233283335371420
of2280273401466496
new24072734014666118192
medicines.26412734014684136191214260283339392436467
Considering31392734014670124180224247303355391414470525
their3696273401464398151174210
importance,39372734014633117172227263296348404450503533
National45022734014676129162185239295347370
Cancer49042734014669122178224277312
Institute52482734014647102147180203237293326379
(USA)14932884014638104160219257
has17812884014658111155
funded1967288401463489145200253308
and23062884014655110166
initiated2503288401462581103137160212246298354
a28882884014654
major29752884014684137165219255
screening3262288401464692128180233289312368423
program3716288401465793147202238289373
for4120288401463487123
antitumor42752884014654110143166200256340394430
activity47362884014655101134157207230263312
from5079288401463470124208
natural53182884014657110143199235286309
resources.1493303401463688133187243279325377422452
By19763034014679129
conducting21373034014666120176231287333367389445501
a26693034014672
random27733034014656107162218272356
screening,31603034014665111147199252308331386442472
NCI36633034014687147184
has38793034014676128173
determined40833034014675128161214250334357413465521
that46353034014653109162195
more486130340146105159195247
than51393034014654110162218
100053883034014675129184239
different1493318401465578110141193229281337370
phytochemicals18953184014669125174207262308364416500523569622645689
possess26153184014670124169214266311355
potent30023184014669124157210265299
anticancer33323184014667123156179225278334380432468
activities.38323184014667113146169219242275298351395426
Of42893184014685117
the44373184014648104156
250,00046253184014669123178208263317372
plant5028318401467093145201234
species52943184014658114166212235288333
available,14933334014652102152175198251306329381412
less1936333401462073117162
than2129333401463187139195
10%23553334014652107204
have25913334014653105154206
been28293334014652105157213
tested3074333401463083127161213269
for3374333401462983119
biological3524333401465376130153207262285331384407
activities,3962333401465096129152202225258281334378409
and44023334014650106161
among45943334014650134188244299
them4925333401463086139223
only51793334014652108130180
a53913334014649
few5472333401462980155
have14933484014656108157209
gone17333484014654108164217
through1981348401463287123177233288344
extensive23563484014651101134187242287310360412
high-throughput2799348401465477132188224258313349403459514570625681715
screening3545348401464289125177229285308364419
process.3995348401465490144190242287332362
This43883484014657113136180
indicates4599348401462177133155202254287340385
that5015348401463287140173
there5220348401463187140176228
is5479348401462166
a55763484014651
large1493363401462375111166219
untapped17433634014656112146198253309361417
source2191363401464599155191237289
of2512363401465486
phytochemical-based26293634014656112161194249295350403487510556609631668723776820873928
anticancer35883634014653109143165212264320366419455
agents40743634014653108161217250295
remaining4400363401463689173225248304327382438
to4869363401463488
be49883634014656109
discovered.5128363401465679123169224273325361413468499
Therefore,14933784014658114167203255287340376428459
it1983378401463568
is2083378401463479
crucial2193378401465894150196219271294
to2519378401464599
carry26503784014657110146182232
out29133784014666122156
more31003784014696150186238
rigorous3370378401464770126180216270325370
research37713784014648100145198250286332388
to41903784014645100
identify4321378401463590143198232255287335
promising46873784014668104157241264309332388443
anticancer51613784014664120154177223275331377430466
candidates1493393401464699154210233288340374426471
from1995393401464379133217
natural22433934014667120153209245296319
sources.25933934014656110166202247300345375
Sanguinarine14934164014656108164219275298354406442465521574
(SNG)20984164014673129196262301
is24304164014658103
a25644164014688
benzophenanthridine26834164014690143199243297352408461517569625658714750773828851907960
alkaloid36744164014687110160213236290313368
that40734164014669125177210
has43154164014691143188
been45344164014691143196252
shown48174164014680136190264320
to51684164014669123
inhibit53224164014659114170193248271305
proliferation,1493431401465591145168191223275311361395418472528558
and20774314014653108164
induce2272431401461874129185231283
programmed2582431401465591145200236287371455507563
cell3176431401464194116140
death33424314014655108160194249
in3623431401461873
various3728431401464495131154208264308
human40634314014655111195248304
cancer4398431401464193149195248284
cell4713431401464194117140
lines.488443140146184197149194224
It5139431401463266
has52314314014656108153
been54104314014655108161217
reported1493446401463688143198234267320375
that1899446401462884136169
SNG20944464014655122189
has23084464014656108153
a24864464014653
more25644464014684138174226
profound2816446401465591145177230286341397
cytotoxic3244446401464090123177211265314337383
effects3652446401465385116167213247291
against39694464014652108160183239283317
tumor4317446401462783167222258
cells4606446401464092115139183
when48144464014675130183239
compared5084446401464094178234286322374430
to5545446401462782
normal14934614014656110146230283305
cells.1830461401464395118141186216
This20744614014659115137182
preferential2287461401465288141172224260312368401424477500
selectivity2818461401464194117170216249272322345378427
of3276461401465283
SNG33914614014652119186
makes36054614014684136186238283
it3919461401462053
a40034614014650
‘druggable’4084461401461873109165221276328384407459480
moiety45924614014684139161214247296
in4920461401461975
the5026461401463186139
treatment5196461401463167119171205289341397430
of1493476401465486
cancer.1610476401464294150196249285302
This19394764014658114137181
research2152476401463183128180233269314370
was25494764014674126170
focused2751476401462780126182227279335
on31124764014655110
elucidating3254476401464871126173195251303337360415471
the3756476401462984137
molecular39204764014684138161213260315338391427
signaling4378476401464063118174226249272328383
mechanism47884764014684137183238291347370414498
of5313476401465486
antileukemic543047640146481041371601493491401462375131181233317340386
potential19104914014659113146199255288311364386
of2328491401465789
SNG.24484914014659126193223
In1493506401463793
summary,16175064014647103187271323359409431
there2079506401463692144180232
is2343506401462570
an24445064014655111
immense25865064014625109193246302346399
potential30165064014658113146199254288311363386
of3433506401465789
SNG35535064014658125192
can37765064014649101157
serve39645064014648100136186238
as42335064014655100
an43645064014655111
excellent45065064014655105150203226249301357391
novel49285064014658113162214236
antitumor51965064014655111144167200256340395431
agent.14935214014652108160216250280
Therefore,18015214014658114166202254286340376428458
it2290521401462053
is2374521401462064
worthwhile24665214014674128164198253327383406429481
to2979521401462984
systematically3094521401464191135169221305358391414460513536559609
investigate3734521401461975124176220254277332384418470
the4236521401462985138
anticancer44055214014649105138161207260315362414450
potential48835214014655109143195251285307360383
of5297521401465182
SNG.54075214014656122189219
Such14935364014656111158213
investigations1738536401463591139191236269292347400433456511566611
can23805364014658111167
provide25785364014667103157207229285337
a29475364014664
scientific30435364014656102125178234267290317343389
basis34645364014667120164187232
for3727536401464497133
designing38925364014667120164187243298321377432
targeted4356536401464598134188241274327382
animal47705364014664120143227280302
and51045364014664120175
human53115364014668123207260316
studies1493551401464578134189212265309
aimed1833551401465881165217272
at2137551401465790
developing22585514014660113163215238292347370426481
safe27705514014649102134185
and29875514014657113168
efficacious3186551401465789116142189241287310364420465
SNG-based36825514014660127194230285338383435490
anticancer42045514014657113146169215268323370422458
therapy.4693551401463994147183234289339360