246
267755989012055111
SARA5776800243104252368516
SHAABAN11496800243104240388536652800948
SHARKAWI215368002431042403885046287769561012
SAYED32216800243104252376480620
Department577920014684161240319358394506583655691
of1302920014677110
Pharmacology1446920014667139218257369449525602631708787857
College5771080014694170199228305384461
of10711080014677111
Medicine121510800146108185264293370399471548
and17961080014679151231
Health20601080014682159238267303375
Sciences24681080014663139168245317394471523
Title438180601344673106132202
Role14181727018873128159208
of1653172701885592
Tumor17721727018868125210265308
Necrosis21081727018879128177219274317348391
Factor25261727018873128177208263306
Alpha28551727018874104159220275
(TNF-α)31581727018836104183256293360397
in3582172701883192
Hippocampal37021727018885116171226281330385470525580611
Neurodegeneration43401727018880129190233288343391446495556605648703734764819880
Faculty4382032013453125196262288321385
Advisor8542032013481154215242290361396
Prof.14182029016061100159194220
Abdu16722029016066127188249
Adem19562029016066126184277
Defense4382251013477147178249315363433
Date9022251013477150183253
214182248016060
May15122248016085143197
201617432248016060121181241
Abstract4383906013481154202235271343414447
Tumor14182451016064115208268307
necrosis17602451016075133184224283332357406
factor22012451016049105156193253292
alpha2528245101607297158219277
(TNF-α)28392451016057121194252292353395
is3268245101604089
a33912451016073
proinflammatory34982451016075115174199261290319377469561619656716755810
cytokine43422451016066120157217272297358416
with47922451016096122159220
homeostatic50462451016076136228286346395432489526551602
and56832451016072133194
pathological59112451016076133170231291316376437462513571596
roles1418260201604099124182231
in16832602016057119
the18362602016069130188
central20582602016083141202239279335360
nervous24522602016094151191246305366415
system.29022602016080135184221279371405
Previous33412602016093132190244270329391440
studies38152602016081118179240265323372
suggested42222602016081142203264321370407465526
a47822602016090
neuroprotective49062602016094152213253312373412471508566617653679733791
role57312602016071131156214
for59792602016067126165
TNF-α61792602016096169227266328
mediated14182752016092150211236294331389449
through19022752016048109149208269330392
TNF-receptor1.23282752016076149206246286343394452513549609649709742
The31042752016076138195
main33452752016092150175237
objective36162752016071132163221272308333388445
of40962752016071106
this42362752016048110135184
dissertation4454275201607297147196253293330388424449509571
is5059275201603786
to51792752016048108
study5321275201606097159219274
the56302752016048109167
role58312752016051110136194
of60592752016071106
TNF-α61992752016076149207246308
in1418290201602587
kainic15392902016061118143205230281
acid18542902016064114140200
(KA)-induced20892902016048112178221260286347408469520578639
neurotoxicity27622902016067125186226285322382435460511536573627
and34232902016064125186
to36432902016043103
find3780290201603565126187
out40012902016066127164
a41992902016064
possible42972902016067127176225250311336394
mechanism(s)47312902016093150201262320382407456548590639682
underlying54472902016067128189247287312367392453514
its5996290201603067116
effects.6147290201606499133190240277326360
Compared14183052016066126218279337376434495
with19433052016082107144205
wild-type21793052016081106132192232269323384442
(Wt-mice),26553052016038137174212304330380438480514
TNF-α31993052016064138195235296
knockout35293052016051113172223278337398435
(TNF-Ko)39983052016038103176233273338395437
mice44653052016093118168226
were47223052016081139179236
more49893052016092152192249
susceptible52723052016045107156207264325362387448473531
to5837305201603393
KA-induced59613052016064130168193254315376427485546
neurotoxicity,14183202016061119181220279316376429455505530567621645
showing20973202016069131190272297358419
more255132020160112172211269
severe28543202016069127182239278336
seizures,32243202016069127152201262302359408442
measurable370032020160112170228277338378434495520578
behavior43123202016081139200258312337397436
changes47833202016070132190251312370419
and52363202016078139200
greater54703202016081121178236272330370
hippocampal58743202016082107168229288339397489550608633
neurodegeneration.14183352016061119181220279340398459517578636676732768793853915948
Neuroinflammation23953352016074132193233292317378408437495587679737774799859920
was33453352016081138187
evident35663352016053108133194252314350
by39463352016061115
increased4096335201602081132172229287336394454
hippocampal4580335201606287148208268319377469530588613
IL-1β,5227335201603691123183244277
IL-65538335201603791123183
and57563352016053114175
IL-125965335201603691123183243
levels6242335201602179133190216265
and14183502016058119180
decreased16323502016076134184224281339388446507
IL-1021733502016056111142202262
levels.2470350201604097152209234283317
TNF-Ko28213502016079152210250314371
mice322735020160106132182240
hippocampi35023502016076101162222282333391483544569
showed41053502016064125185267324385
more452535020160107166206263
oxidative48233502016074128153214271308333388445
stress,53023502016064101140198247296329
lower5666350201603999181239278
IGF-I,59793502016055129186226266299
and63123502016073134195
higher1418365201606187147209267306
β-NGF17593652016069109182255313
levels2106365201603491146203228277
compared24183652016059118211272329369426487
to29403652016044104
Wt-mice.30873652016099136173266291342400433
GSH35543652016082143217
was38063652016090146195
elevated4036365201606691149204259296354415
only44853652016068129155209
in4729365201603394
Wt-mice,48663652016099136173266291342400433
while53333652016090151177202260
catalase56273652016059117153211236294343401
and60623652016066128189
SOD62853652016069147222
were14183802016082139179237
elevated1689380201605782140195250287345406
more21283802016093152192249
in2412380201602485
TNF-Ko25323802016063136194234298355
mice.29203802016093118169227260
Hippocampal32133802016075100161221281332390482543601626
microglial38723802016093118168208267328353378436461
activation43683802016056107144169224280316342401463
and48653802016057118179
astrogliosis50783802016057106143183242303328353413462487536
were56473802016082140180237
enhanced59183802016057119180238299350408469
in6421380201602486
TNF-Ko14183952016064138195235300356
mice.18113952016093118169227260
Additionally,21053952016069130191216253278338399457482507562586
the27253952016040101159
expression29183952016061115176216273322371396456518
of3470395201606297
hippocampal3602395201606489150211271321379471532590615
NFκB42523952016075133187252
was45423952016081138187
significantly4763395201605277138200225254283334392453490515570
up-regulated53673952016064125165205262323384409467504562623
in6024395201602889
TNF-Ko61483952016067140197237302359
mice.14184102016092118168226259
Altogether,1712410201607095132191252310347408466506524
this22714102016040102127176
study2481410201605390151212267
showed27824102016053115174256314375
that31914102016041102160197
deficiency34224102016065123152181232257315376427482
of3938410201606499
TNF-α40714102016068142199239300
worsens44094102016082142181230288350399
KA-induced48424102016069135172197259319381432489550
neurotoxicity54274102016065123184224283320379433458509534571625
resulting60864102016043101150211236273299360421
in1418425201602587
uncontrolled15394252016080141192252313350389448474499557618
oxidative21914252016078132157218276312337392449
stress,26754252016067104143201250299332
glial30424252016079104130187212
over-activation,32894252016078132189229267324375412437492547584609669730764
lack40874252016044101152207
of43284252016078113
neuroprotective44764252016080137199238298358398457494552603639665719776
mechanisms528742520160111169219281338400425474566616
and59374252016076137198
results61704252016058115164225251288337
in1418440201602587
a15394402016069
vicious1642440201606691142167227289338
cycle20144402016062117167192250
of22984402016071106
chronic24384402016062124163223284309360
neuroinflammation,28324402016073131192232291316377407436493586678736773798858919952
oxidative38194402016071124149210268304330384441
stress4295440201606097137194243292
and46224402016069130191
neurodegeneration.48474402016073131192232291352409470528590647687743780805865926959
These58414402016075136194243301
results61774402016051108157218244281330
highlighted1418455201606187147209234259320381418476537
the19894552016052113171
protective21954552016076115174211269320356382436493
effects27234552016073108142199250286336
of30934552016075110
TNF-α32374552016080153210250311
in35834552016040102
KA-induced37194552016080146183208270330392443500561
neurotoxicity43154552016076134195235294331391444469520545582636
that49854552016052113171208
may522745520160108166220
be54814552016076134
mediated564945520160108166227252309346404465
via6148455201607095153
the63364552016051113171
regulation1418470201604097158219244302339364424485
of19384702016071106
NFκB20784702016085143197262
signaling2375470201606186147208266291316377438
pathway.28484702016072130167228309366420443
Dissertation3971558017098132193255344389431524566599689773