375
2761965989012055111
Profiles3670599101205989154179203223288327
of4025599101206596
Doctorate41495991012075140205239304334403436501
Dissertations4678599101207595133172237267301369403423489550589
Research1493848013464134183253326361431497
Relevance2021848013464134161231293365431502572
and2624848013472138211
Potential2866848013461132165235301334361433460
Impact3356848013431135207280350383
Neurodegeneration14931004014667119175211265321373429481537590626678711734789844
is2369100401462873
a24731004014658
common25621004014652106190274328384
feature2977100401463790142176232268320
of3329100401465991
a34511004014658
large3541100401462880116172224
number37971004014661116200256308344
of4173100401465991
diseases4295100401466184129181234278331375
that4702100401463994147180
come49141004014651105189242
under51871004014661117173225261
the5479100401463995148
umbrella14931154014656140195231284307329382
of1906115401466395
“neurodegenerative20321154014649105157213249304359411467519575628664716750773822875
diseases”;2938115401466487132184237282334379419454
and34241154014661117172
involve3627115401463287137192214264317
loss3975115401463286130175
of4181115401466395
nerve43071154014665118154203256
structure4594115401465487123179225258314350403
and50281154014661117172
function.5232115401464096152198231254308364395
The14931304014658114167
prevalence16911304014664100153202255278330386432485
of2207130401466395
neurodegenerative23331304014665117173209264319371427479535588624676710733782835
disorders3199130401466487132186222277330366411
such36411304014653109155211
as38831304014661106
Alzheimer’s4020130401466992136192245267351404440461506
disease4557130401466487131184237281334
and49221304014661117172
Parkinson’s51261304014663116152202225280325379435456501
disease1493145401465578123175228272325
is1849145401462368
increasing,1948145401462379125161213266311333389445475
but24541454014655111145
exact26301454014652102154200234
mechanisms28951454014684137183239291347370414498543
and34691454014653109164
effective3664145401465384116169215248271321374
treatments4069145401463369122175208292345400434478
are4579145401465288141
lacking.4751145401462376122171194250305336
The51181454014658114167
burden53161454014655111147202255311
of1493160401465486
these1610160401463692144189242
neurodegenerative18831604014658111167203257312365420473529581617670703726776828
diseases2743160401465780125177230274327372
is3146160401462570
growing,3247160401465894148222245301356386
as3665160401465499
the3795160401463692144
population39711604014657112167223245298331354409464
ages,44671604014654110162207237
with4738160401467497130186
huge49551604014658114169222
economic52081604014655101156211266350373419
and14931754014652108164
human16881754014662118202254310
costs.20291754014652107151185229260
Multiple23261754014677133156189212267290343
components27001754014652107191246300356409464498542
are3274175401465894147
linked3452175401462952108158211266
to3749175401464094
the3874175401464096148
pathogenesis40531754014662114148204258313366422474519542586
of4671175401466092
neurodegenerative47941754014662115171207261316369424477533585621674707730780832
diseases1493190401465578123175228272325370
including1894190401463691138160216272294350406
protein23311904014668104158191244267323
aggregation,26851904014665120176212264320372406428483539569
mitochondrial32851904014697120153207253309364419475511534586609
dysfunction39251904014668118163194250306352385408463518
and44751904014665121176
oxidative46821904014667117140195247281304354406
stress,5119190401465891127180224269299
diet5449190401466992144178
components14932054014646100184240294350402458492536
and20612054014693149204
neurotoxins,22962054014697150206242296329384433456512556587
vascular29142054014691143188234290313365401
disorders,33462054014697120164218254310362398443473
excitotoxicity38512054014693143189212245299333387437459506528562612
and44942054014694149205
neuroinflammation.47302054014697149205241295318374401427480564648700733756811866897
Neuroinflammation14932204014667119175211265288344371397450534618670703726781836
was23612204014694146191
considered25832204014666120176220243299351387440495
as31092204014673117
a32572204014673
passive33612204014675127172217239289342
response37342204014656108153208263318363416
to41812204014653107
neuronal43202204014675128183219274330382405
damage.47562204014675128212264319372402
However,51902204014687141215268318370406436
several1493235401464597147200236288311
studies1835235401465185141196219271316
proved2182235401466298153202255310
that2524235401463995148181
inflammation2736235401463086112139191275359412445468522578
may33522354014684136186
be35692354014662115
a37152354014659
basic38052354014662115159182228
mechanism40712354014684137183239291347370414498
driving4601235401466197120170193249304
the4936235401464096149
progressive5116235401466298152207243296341385408458510
nature14932504014656108142198233286
of1810250401465890
multiple19352504014684140163196219274297350
neurodegenerative23162504014659112168204258313366421474530582618671704727777830
diseases.3177250401465982126179231276329373403
TNF-α,36122504014662129181217272303
as39462504014656101
a40782504014656
proinflammatory4166250401465894149172227254280333417501553587641677727
cytokine,49242504014650100133187237260316368399
exerts53542504014656106158194228272
both14932654014655110143199
homeostatic17232654014660114198251305349383435469492538
and22922654014656112168
pathophysiological24912654014659111145201255310366416460483538560615670693739792814
roles3337265401463994116169214
in3582265401462782
the3696265401463793145
CNS.38732654014663130186216
The41202654014663118171
present4322265401465995148193245301334
study4688265401464882137193242
was49662654014674126171
conducted51682654014650104160215271317351403459
to1493280401463388
elucidate1612280401465679134181203259311345397
the2041280401463692145
neuroprotective22172804014659111167203257313349403436489535569591641694
role2942280401463994117169
of3143280401465789
TNF-α32632804014662128180217272
in3567280401462682
hippocampal3680280401465982137192246293345429484537560
neurodegeneration42712804014659111167203258313365421473529582618670704726781837
and51392804014656111167
to5337280401463691
find5459280401463056112168
out14932954014654110143
the1668295401464399151
possible18512954014664119163208231286309362
mechanisms22532954014684137183239291347370415499543
for2828295401464195131
its2991295401463266110
effects.3133295401466294125178224257302332
The34972954014668124176
results3705295401464598142198221255299
of4035295401466496
this4163295401464398121166
study4360295401465488144199249
added46402954014662117173225281
to4952295401464397
the5080295401464499152
growing52632954014665101155230253308364
knowledge14933104014650106160234257310365420473
about19973104014659114169224258
the2286310401464096148
multiple24723104014684140163196219274297350
factors2853310401463890137170224260305
involved3189310401463085135190212262315370
in3590310401463085
the3707310401463995148
neurodegenerative38863104014662115171207261316369424477533585621674707730780832
process,4750310401466197152198250295340370
specifically51513104014651107159205228255281328380403426476
excitotoxicity,14933254014653102148171204259292346396419465488521571601
neuroinflammation21263254014684136192228282305361388414467551635687720743798853
and30113254014680136191
oxidative32343254014682131154210262296318368421
stress.36863254014673106142195239284314
They40323254014686142195245
also43083254014680103148202
supported45423254014672128183239293329362415470
the50433254014662118170
growing52453254014683119173248271326382
evidence14933404014653102125181233289335388
showing19123404014648103158232255311366
that2309340401463692145178
TNF-α25183404014662128181217272
confers28223404014649103159191243279324
protection3177340401465894149182235281314337391447
for3656340401463489125
the3812340401463692145
neurons,39883404014659111167203257313358388
specifically44073404014648103156202225251278324377400423472
for4911340401463489125
hippocampal5067340401465982137192246293345429484537560
neurons14933554014656108164200254310355
which18663554014674130153199255
are2139355401465288141
the2311355401462076128
focus2471355401461873119174219
of2708355401465486
the2825355401462076129
study.2972355401464478134189239269
Highlighting3259355401466890146202224247303358392415471526
the3816355401462076128
neuroprotective39623554014656109164200255310346400434486532566589639691
side4671355401464568123176
of4865355401465486
TNF-α49693554014658125177213269
provides5256355401465591145195218273326371
an14933704014652108
important16333704014631115170224260294346402435
factor2100370401464092138172226262
to2393370401464296
be25213704014663116
considered26683704014655109165209232288340376429484
for3183370401464095131
future3345370401464096129185221274
studies3650370401465386142197220273318
on39993704014662118
therapeutic4149370401464197150186238293346402435458504
approaches46843704014661117172208262315361417469514
involving5229370401463187137191214264287343398
complete14933854014646100184240263315349401
neutralization19203854014656109165198234287309332377429463486540596
of2542385401465486
TNF-α26543854014658125177214269
for2954385401462781117
treatment3103385401462864117169203287339395428
of3558385401465486
various3675385401464597133156211266311
disorders.4012385401465578123177213268321357402432
We44703854014690143
recommend4644385401463184130184268352405461516
that5191385401462984137170
these5393385401462884136181233
treatments1493400401463369122174208292344400434478
should2003400401464399154209232288
be23224004014654107
examined24604004014652101154238261316369424
on29154004014654110
different3056400401465477109141193229282338371
areas3458400401465288141193238
of3727400401465385
the3843400401463389141
brain4016400401465490143165221
to4269400401463286
avoid43874004014651101155178233
the4652400401463288140
occurrence4824400401465399145201237273326382428480
of5336400401465385
side5452400401464467122175
effects1493415401465384116169215248293
that1817415401463489142175
would20244154014674128184207262
arise2317415401465389112156209
from2557415401463268122206
complete27954154014646100184239262315348401
deactivation32274154014656108161207240263313365399422476532
of3790415401465486
the3907415401463490142
TNF40814154014658125177
signal-transduction4289415401464568123179231254290324360412468513568624670703726780836
cascade.5156415401464799144190242298350380
Relevant14934398013464134161231293365431464
Publications19884398013462128200227253323396429455526592640
•14934554014645
Zhang,16094554014663119171227283313
X.1953455401466696
M.,20804554014685115145
Zheng,22574554014663119172227283313
X.2601455401466696
Y.,2728455401466696126
Sharkawi,28854554014664120172208258310385407438
S.3354455401466394
S.,3479455401466393124
Ruan,36344554014670125178234264
Y.,3929455401466596126
Amir,40864554014668152175211241
N.,43584554014675105135
Azimullah,45244554014668112135219275298321373429460
S.,5015455401466393123
Hasan,51704554014675127172224280310
M.55124554014684115
Y.,1493470401465888118
Zhu,16424704014674129185215
J.,1889470401465989119
Adem,20404704014677132184268299
A.23704704014677108
(2013).25094704014655110165219274312342
Possible28834704014672126171215238294316369
protecting32834704014673109163197249295329352407463
role37774704014653108130183
of39914704014672104
TNF-alpha41264704014676142194231283306361417470
in4627470401464096
kainic47544704014667120143198221267
acid-induced50534704014669115138194230253309364420466518574
neurotoxicity14934854014656108164200254288342392415461484517567
via2091485401465174126
down-regulation22494854014656110185240277313365421476499552585608662718
of2998485401465688
NFkappaB31184854014667119169221277332384443
signaling3593485401464568124179232255278333389
pathway.40134854014656109142198272325374405
Curr44494854014661117153189
Alzheimer4669485401466184129185237260344397433
Res,51334854014663116160191
10(6),53554854014656110149203241272
660-669.14935004014655109164200255309364394
•14935154014645
Sharkawi,16105154014664120172208258311385408438
S.2079515401466495
S.2205515401466495
and23315154014661117172
Adem,25345154014669124177261291
A.2856515401466999
(2016).29865154014647102156211266304334
Tumor33525154014666122206261297
necrosis36805154014664117163199253298321365
factor4077515401464092139172226262
alpha4371515401466184139195247
in4650515401463187
kainic47685154014658111134190212259
acid50585154014661107130185
induced5274515401463288143199245297353
neurodegeneration.14935304014656108164200254310362418470526579615667701723778834864
International2388530401463893127179215271324357380434490543566
Conference29855304014660114170202255291343399445498
in3514530401462379
Educational36245304014656112168214266300322377433485508
Neuroscience41635304014667120175211266310356379432488534586
(ICEN),4781530401463876136192259297327
Abu51395304014661116172
Dhabi,53425304014668124176232254285
UAE;14935454014666126182217
February,17415454014653105160196252305341390421
2016.21935454014655109164219249
(Poster2473545401463893148192226278314
Presentation).2819545401465591143188241296330382416439493549587617
•14935604014645
Sharkawi,15995604014654110162198248301375398428
S.2058560401465485
S.2174560401465484
and22895604014651107162
Adem,24815604014660115168252282
A.2792560401466091
(2016).2943560401463791146201255294324
Effects3298560401465486118171217250295
of3624560401465385
Tumor37405604014656112196251287
Necrosis40565604014667119165201256300323368
Factor44555604014651103149183237273
Alpha4758560401466083138194246
on50355604014653109
Cytokines,51735604014660110143198247270326379423454