182
387755989012055111
SHAIKHA5777370243104240388444568704852
SAIF14857370243104252308404
SAEED19457370243104252356460600
ALNEYADI26017370243148236384488612760900956
Department577977014684161240319358394506583655691
of1302977014677110
Chemistry1446977014693165242355384437473511581
College5771136014694170199228305384461
of10711136014677111
science12151136014653130159236308384461
Title438180601344673106132202
Design,14181727018879128171202257318345
Synthesis17911727018861110171202263312354385428
And22421727018874135190
Biological24591727018874104159190245300330379434465
Studies2951172701886192153208239288330
Of33091727018879116
Some34521727018862117202251
Novel37301727018880135184233263
Pyrimidine40211727018867116159189275305360391452501
Derivatives45491727018880129171202251306336367416465507
Faculty4382032013453125196262288321385
Advisor8542032013481154215242290361396
Dr.14182029016075114133
Ibrahim15852029016041102142197259284376
M.19962029016085118
Abdou21482029016066127188248309
Defense4382251013477147178249315363433
Date9022251013477150183253
1914182248016060120
May15732248016084142196
201618032248016060121181241
Abstract4383906013481154202235271343414447
Increasing14182451016041102153192250307356382443504
incidence1956245101601778129154215273334385443
of2425245101606095
diabetes2546245101606086143204262299357406
and29782451016058119180
antimicrobial31842451016057119156181273298349389448509534592617
resistance3835245101603189138163212249306368419476
are4338245101605797154
considered45272451016042102163212237298356396453514
of5067245101606095
the5196245101602890148
most53702451016092152201238
common56422451016042102195287347408
concerns60852451016042102163214271311372422
in1418260201602587
the1539260201603899157
medical17322602016092150211236287344370
field.2136260201603060118143204237
This24072602016066127152201
research2643260201604098147205263302352414
is3091260201602776
aiming3201260201605984177202263324
to3559260201603898
design,36912602016062120169194255317350
synthesize40752602016050105167203265323372397446503
and46122602016059121182
biochemically4828260201606287147198259317409434485543568593648
evaluate55112602016059113169194256313350408
some59532602016051110203261
novel62482602016063122176233259
pyrimidine14182752016061115155180273298359384445503
derivatives19552752016082140179204259315351377431488538
for25272752016056114154
potential27152752016082141178236297334359417442
remedies31922752016060117210268328354411460
in36872752016046107
combating38282752016072131224285342379404466527
diabetes43892752016081106164225283320377427
Type48502752016085129190248
251332752016080
and52482752016078139200
common54832752016071130223315375436
pathogenic59542752016081139176237297358415477502553
bacteria.14182902016061119169206264303329386420
Pyrimidine18682902016061115155180272298359384445503
derivatives24012902016061119158183238294331356410467517
were29482902016081139179236
synthesized3219290201604499161197259317366391440497558
and38112902016054115176
its4021290201602158107
structures4162290201604582122183234270332371429478
were46702902016082140179237
elucidated4941290201605479140191216277335371429490
using54612902016061111136197258
the5753290201603394152
most59352902016092152201238
recent6207290201603693144202263300
spectroscopic14183052016049110168218255295354403454514575600650
techniques.21033052016056113164226287312373434492541575
The27123052016083145202
preliminary29493052016080119177202227320345406464503558
results35423052016058116165226251288337
indicated39143052016044105166191242300336394455
that44043052016055117174211
some46493052016069128221279
of49623052016079114
the51103052016056117175
synthesized53203052016068122184221282340389414463520581
pyrimidines59363052016079134174199291316377402464522571
represent1418320201604097158197255304362423460
valuable19123202016058113139200258318344402
anti-diabetic23483202016060122158184224284310367428486523548599
activities29813202016060111148173228253290315373422
and34383202016060121182
showed36553202016051113172254312373
a40623202016061
good41573202016063123183244
starting4435320201605289146186223248309370
point48393202016064124149210247
for5120320201603897136
the52913202016039100158
design54843202016063121170195256318
and58363202016060122183
discovery6053320201606389138188248302359399454
of1418335201606095
small-molecule15473352016060153211236261301393453478536587648674731
GLP-123133352016084139200240300
agonists26473352016069130190251276325362411
that30923352016048110167204
can33313352016062119181
be35463352016072130
administered37103352016069130222248309334383420478517575636
orally,43803352016071110166192217272295
while47103352016093154179204262
other50073352016070107169226266
derivatives53073352016072130170195250306342368422479528
were58703352016093150190247
able61523352016069130155213
to63993352016048108
activate14183502016058108145170225281318375
PPARγ18283502016067128191260314
and21773502016064126187
enhance23983502016064126187245306357415
insulin2847350201603294143204229254316
sensitivity.31973502016056114175224249286311366391428482506
The14183652016064126183
antibacterial16363652016053114151176237295345382440480505563588
activities22583652016053104140166220246283308366415
exhibited27073652016053108169194255280317375436
promising31723652016061101160252278327352413474
results3680365201603592141203228265314
with40243652016081106143205
better42583652016061119156192250289
IC5045823652016036102162222
values48383652016050106131193250299
compared51723652016046105198259316356413474
to5681365201603191
some58073652016044104196254
common60953652016046106198291350412
antibiotics.14183802016058119156181242267327364389439489522
To197438020160100148
confirm21573802016085145206236265305397
the25893802016071133191
antibacterial28143802016093154191216277335386422480520545603628
activity,34763802016093144181206261286323377400
the39113802016072133191
interaction41363802016061122159217256312363400425485546
between47163802016096154191273330388450
selected52003802016084142167225276313371431
compounds56663802016086146238299359420481542591
and62923802016093154215
β-lactamase14183952016061101126184235271329422479528586
enzyme20393952016061122171226318376
was24533952016082139188
studied2675395201605389151212237295356
using30653952016065114139200261
FT-IR,33613952016060126158198266300
NMR,36953952016077162230263
UV-Vis.,39933952016075141178241266316349382
fluorescence,4410395201603261123182222279328379437498549607640
TEM,50853952016068129214247
and53673952016061122183
CD55853952016069144
techniques5763395201604098149210272297358419477526
and63233952016062123184
molecular14184102016092152177235286347372430470
docking.19224102016085145195250275337398431
Dissertation3971558017098132193255344389431524566599689773