458
206316470016778155
Ray66712170234158296396
M-Esam112112170234177227335431569746
Al192512170234137246
Barazie222912170234117246405542684736844
Department6681431014981155232313348384495569643679
of13841431014975111
Biochemistry1532143101495372147216285359470490534571605665
College6671575014989164183203277358433
of11371575014975111
Medicine128515750149110184264284353373446521
and18421575014981155236
Health21141575014974148229248285354
Sciences25051575014954123142217290359433478
Dissertation6671863017098132193255344389431524566599689773
Title66720580122426696120184
Mechanisms14932060012092157222283351412432471564603
underlying21242060012061122190255285305359379440507
control26592060012065130191225255321341
of3027206001206697
anti-microbial31522060012068129163183216310330395425491559579647667
immunity38472060012020113207268329349383437
by43112060012068122
acetylcholinesterase446120600120681331982322853053704314965165365976637017358008308999371002
inhibitors.5491206001202081142162230250284350380419446
Faculty6672213012248114178238262292350
Advisor10452213012274140196220264328360
Dr.14932215012074104125
Maria16462215012091160190210278
J.1952221501204876
Fernandez-Cabezudo2055221501204911414420727533640547051254662769576382887193210001066
Defense6672368012270134162226286330394
Date10892368012270136166230
3014932370012055111
April16322370012073142172192212
201518722370012055110166221
Abstract6672683012274140184214246312376406
Inflammation14932690096186786106160235310365392408461509
is202526900961950
a2100269009655
crucial218026900965276125176192247263
defense2468269009655107132184233264316
mechanism2810269009675127178227282331347378453
that328526900963079134161
protects347126900965579131158210262289320
the381326900963079131
body3969269009655107162205
from419626900962953105180
the439826900963079131
devastating4554269009655107152206237264319346362411465
effects504426900965277103155206233265
of533426900965277
invading543426900961968112167221237286340
pathogens.5799269009655110137185238292344393424446
However,1493278609655107174226270322346360
an1878278609655103
unrestrained2004278609651100124176207234258313329378430484
inflammatory25112786096196887106161236311366393445469512
reaction304527860962879134186213229281330
may3400278609675130173
result359527860962779110159175202
in381927860961968
systemic390927860963477108135187262278330
manifestations4264278609675130179195220272303330385412428480529560
with484927860966783110159
dire50332786096557195147
consequences5205278609652104153184236291339391440492544575
to580227860963083
the590727860963079131
host.6060278609652104135163185
The149328820963483135
extent1650288209663101128180229256
of192828820966489
activation2039288209665117144160204259286302355403
of246528820966388
the257528820963887139
inflammatory27362882096277695114169244319374401453477520
response327828820963587118173225274305357
is365728820962758
tightly373728820963854108157184200243
regulated400228820963586140189205259286338393
through441728820963887111163212266315
immunological4754288209626102177225274326342395449465516571587
and5363288209666114169
neural5554288209660112161185239255
pathways.5832288209665120147195262317359391413
Previously,149329780964771123167183236284315331374397
we1912297809686138
demonstrated2072297809674126201254303334361385439467519573
that266729780964796151178
cholinergic2867297809671120172188204253305329383399451
stimulation33402978096517894169217233288315331384432
confers3794297809672124173198250274305
enhanced4121297809672121170224273325377432
protection457529780967498150177229281308324376425
in502229780963685
experimental5129297809671110164216240256331383432459514530
animals5681297809674123139214269285316
orally601929780967296151167183226
infected14933074096166590142194221273328
with183830740966783110159
a2015307409654
lethal20913074096126491140195211
dose2319307409655108139191
of252730740965378
Salmonella262330740963994110185238286338354370425
typhymurium.307030740962366120169212287336360376424499522
In361430740961362
this36983074096237288119
study,383930740962754103157200222
we4079307409667119
investigated422030740961160105157188215231285339366418473
the471530740962372124
mechanism4857307409675127178227282331347378453
by532730740965598
which5443307409666115131183232
this56973074096227187118
enhanced5833307409652101150204253305357412
protection149331700965579131158210262289305357406
takes192131700962680121173204
place.214531700965571126177229251
We2417317009677125
showed256431700963079131198250305
that289131700962574129156
cholinergic3068317009652100153169185234286310363379431
stimulation35213170096305773148197213267295311363412
enhanced3954317009652100149204253304356411
host4386317009649101132159
survival456731700963079103147163207262278
following48673170096247692108161227243292346
oral-route523431700965276131147173197249298325377
infection,56333170096156489141193220236288337359
which6013317009666115131183232
correlated1493326609652104128152204220275302354409
with192332660966682109158
significantly210332660963046100149165184204256310359386402445
reduced257032660962375130178230282337
bacterial2928326609655109161188240264280335351
load330132660961568122177
in350032660961564
target358632660962681105159211238
organs,384532660965277130185234265287
including415432660961564116132180235251300354
livers45303266096153175127151182
and4734326609654103158
spleens.491432660963085101153205253284307
Enhanced524232660964392140195244296348402
protection566532660965579131158210262289305358406
was6092326609667122153
not1493336209649101128
due1643336209665113165
to183033620963789
increased194133620962674126150202257288340394
gut2358336209663111138
motility2528336209675127154170186202230272
or282333620966185
rapid293133620963387142158213
bacterial3166336209664119170197249273289344360
clearance354833620966177129184208263312363415
from398533620963559111186
the419333620963785137
GI436233620967088
tract.447233620963660115167194216
Moreover,4719336209674126150202254299351375389
protection513033620966488140167219271298314366415
against5567336209664118172188237268295
bacterial5885336209663118170197249273289344360
infection14933458096166590142194221237289338
was1853345809679134165
lost204034580962881112139
when2201345809679128180228
the245134580964089141
animals2614345809667116132207261277308
were2945345809678130154206
infected317334580962977103155206233285340
systemically,353534580964487118145197272288340394410426469491
suggesting404834580964493146200252283310326375429
that449934580964088143170
the469134580964089141
acetylcholine-mediated4854345809667118170198240256308357409425441490542569644696751767821848900955
protective583134580966791143170222274301317362414
effect149335540965277102154206233
was1757355409666121152
mostly1939355409675128159186202245
confined2206355409660112161181200249301356
to258435540963588
the269435540963584136
gut2852355409662111138
mucosal3020355409675124176228259314330
tissue.33723554096355182113162214236
In363035540962675
vivo372735540965369113166
imaging391535540962499154208224272326
demonstrated4263355409663115191243292323350374429456508563
more4856355409675127151203
localized508135540962477129183199215249301356
infection54593554096247398150202229245298346
and5828355409662111166
delay6016355409663115131186229
in149336500961665
bacterial1580365009673127179206258282298353369
dissemination197136500967389120151203278294343398425441493542
into253536500963483110163
systemic272036500964992123150202277293345
organs308736500967195149203252283
in339236500963583
mice3498365009693109161213
pre-treated373336500967397148175202226278332360412466
with4221365009685101128177
acetylcholinesterase4420365009673125177204247263315363416432448497549580607659683738769821
inhibitors.526336500963483132148202218245298322353375
Morphological5660365009692144168223272324340392446462514569585
analysis1493374609655103158174217248264295
of181237460965277
the191237460962877129
small2063374609633108163179195
intestine22803746096176693145176203219268320
(ileum)26223746096314763115164239269
showed291337460963281134200252307
that324237460962978132159
acetylcholinesterase3425374609655107159186229245296345397413429478530561588640665719750802
inhibition424937460961867116132186202229245298346
induced461837460961766121169221273328
the496837460962978130
degranulation5121374609655107161185240289337353408435451503552
of569737460965277
goblet5798374609654106161177229256
cells6078374609652104120136167
and1493384209655103158
Paneth1673384209651106155207234283
cells,1981384209652104120136167189
two219238420963197150
specialized236438420963589141193209263279295329381436
secretory282238420963587139163215242294318361
cells3209384209651103119135166
involved339838420961968112165181225277332
in375238420961968
innate384238420962069118172199251
immunity.411538420962095170219267283311353376
Our4516384209670118143
findings46813842096234291146162211264295
demonstrate5002384209655107182234283314341365420447499
a5527384209654
crucial560738420965276124176192247263
pathway5896384209654109136185251306349
between1493393809655107134200252304353
neural1868393809653105154178233249
and2143393809655103158
immune232339380962196171219268320
systems266539380963679110137189264295
that298239380963180135162
acts3170393809655107134165
at336139380965582
the346539380963281133
mucosal3624393809675124175228259314330
interface39763938096206996148172201256307359
to435839380963183
protect446839380965478131158210261289
the477939380963180132
host4933393809653105137164
against5123393809655109163179228259286
invading543139380962169114168223239288342
pathogens.5799393809655110137185238292344392424446
Keywords:14934128097501011472112622883413761869413009622
cholinergic1913413009652101153169185234286310364380432
pathway,2367413009654109136185252306349371
bacterial2760413009655110161188240265281335351
infection,31334130096166590142194221237290338360
innate351641300961664113168195247
immunity,378541300961691166215264280307350372
intestinal41794130096166592144175202218267322338
mucosa.4539413009675123175228259313335
Research6244408017081171232322414459549633
Relevance12964408017081171204294372465549638728
and20634408017093177269
Potential23714408017079168210300384426459552585
Impact29964408017039170263355445487
The62446050963483135
study78146050962855104159202
demonstrates1002460509655107182234283314341365420447499530
that155446050962574128155
cholinergic1729460509651100153169185233285309363379431
stimulation21824605096295672147195211266293309361410
regulates261446050962273127176192247274326357
immune299346050961388163212261313
response332846050962173104158211260291343
at369046050965582
the379446050962473125
mucosal3938460509676124176228259314330
intestinal42904605096136289141172199215264319335
interface,46474605096136289141165194249301353375
thus504446050962473122153
highlighting521646050964965119168184200253302329345394448
the568646050962573125
intricate58334605096146390114130181236263315
link61704605096143078119
between624470109655107134200252304353
nervous999470109652104128172225273304
and1329470109654103158
immune150947010961994169218267319
systems.185047010963477108135187262293315
Our2191470109669118142
findings23554701096234291146162211264296
suggest267347010963482136190242273300
the299547010963180132
potential3152470109654107134186235262278332348
use352347010965182134
of368347010965277
this37824701096317995126
pathway3934470109654109136185251306349
to430547010963083
control4413470109652104153180204256272
chronic4711470109651100124176225241293
inflammatory50264701096196887107161236311366393446470513
intestinal55614701096196895147178205221270324340
disorders.592747010965470101154178232284308339362
These62447970963483135166218
results86447970962476107156172199230
could1116479709652105153169224
provide136347970965478130175191245297
a1683479709655
therapeutic176047970962776128152207261313362389405457
advantage2239479709655110154209257285339393445
for270647970962678102
the283047970962877129
design2981479709655107138154208256
of326047970965277
novel3360479709649101145197213
pharmacological3596479709655103158182259314366418434487540556608663679
anti-inflammatory4297479709655104131147173189238258277332407482536563616640683
strategies.50024797096315883137164216270286338369391
Relevant6244924017081171204294372465549591
Publications12544924017078162255288322412504546580669753815
•624517709648
R.71751770964871
Al-Barazie,81051770965975101147202226281315331383405
G.123751770967092
Bashir,1351517709646101132181197221234
M.M.160751770967496170192
Qureshi,1821517709670118142194225274290312
Y.215551770964864
Mohamed,2242517709673126174229304356411433
B.K.269751770964668115138
al-Ramadi28575177096547097146200275330385401
and3280517709654103158
M.J.346051770967496134157
Fernandez-Cabezudo.363951770963991115165220268323375409436501555610662696745799852874
Acetylcholinesterase4535517709659111163190233249301350402418434483535566593645669724755807
inhibition536451770961665114130184200227243296344
modulates5731517709675127182231247301328380411
the71352730962776128
mucosal863527309675123175228259313329
interphase12145273096166592144168223272326357409
by164652730965497
enhancing1765527309652101150204253305321370424
the221152730962776128
gastrointestinal2361527309654108139167191242258307334386417445461509564580
barrier2963527309655109133158174226250
defense3235527309655107132184232264316
mechanisms.3573527309675127178227282331347378453484506
(In41015273096304897
preparation)422052730965478130185239263318345361413462492
Career62454800170109202246336426470
Aspirations113454800170103165257291336428470504593677739
My624573309674116
aspiration76357330965485140156180235262278330379
is116457330961647
to123357330962780
be1335573309654106
in146457330961664
a1551573309654
career1627573309652107131182234259
that190857330962776130157
I2088573309618
enjoy2128573309652101117169212
and2362573309655104159
love254357330961668112164
as273057330965485
myself,2837573309675118149201217242265
be3124573309654106
beneficial3253573309654106155207226246298314368384
for365957330962678102
people3783573309655107159214230282
and4087573309654103158
help4267573309649101117172
in446157330961665
the454857330962776128
improvement469857330961691145169221266318393445493521
of524157330965277
human534057330964998173228276
lives.56395733096163276128159181
Also584257330965975106159
I6023573309618
would624582909666119168184238
like8845829096163273125
to103158290962779
be1132582909655107
in126158290961665
a1348582909655
position1425582909655107138154181197249298
that174558290962876131158
offers192558290965378103155179210
me2157582909675127
a2307582909654
contentious2383582909652104153180232281308324377425456
development2862582909654106151203219271326401453501529
and3413582909654103158
improvement359358290961691146170222266318393445494521
of413658290965378
my4236582909675118
experiences437658290965290145197221237289338390442473
and4871582909654103158
knowledge,505158290964089142208224276331385437459
has5532582909649103134
a5689582909654
nice576558290964965117169
working5956582909667119143183199248302
atmosphere62459250965582157209240295344396420471
and1117592509655104158
cooperative1297592509652105157211263288342369385430482
colleges.1801592509651104120136188242294325347
I2170592509618
hope2210592509648101155207
to244059250962679
achieve2541592509654106155171223267319
that288259250962776131158
through306259250962776100152200254303
doing3387592509655107123172226
a3635592509654
research371159250962476107159213238289338
in407159250961564
health4157592509649101156172199248
related44275925096237591146173225280
matters4729592509675129156184236260291
as504259250965485
a5149592509655
post5226592509654107138165
doctorate5413592509654107159186238262317344396
professional583159250965478131156208239270286338387442458
or62460210965276
through72360210962776100152200254303
academic1048602109655106161216268343359411
teaching148160210962779134185234250299353
position1856602109655107138154181197250298
where2176602109667116168192243
I2442602109618
can2482602109652106155
provide265960210965579131175191246298
the297960210962776128
best3129602109655107138165
educational3316602109652107156207262289305357406461477
outcomes3815602109652101128180232307359390
and4228602109654103158
experience440860210965290145197221237289338390442
for487260210962577101
the499660210962775127
future514660210962573100149173225
generations.5393602109654106154206230285312328381429460483