446
226316470016778155
Ismail7821085023452148325463515623
Abdel146310850234138254423532640
Karim216110850234165302461513690
Mousa290910850234177340490585723
El369010850234109217
Haty396510850234148286389503
Department7821300014981156232313348384495569643679
of14981300014975112
Chemistry16461300014989158233344363408444479538
College7821444014989164183203277358433
of12521444014975111
Science14001444014954123143217291360434
Dissertation7811871017098132193255344389431524566599689773
Title78120660122426696120184
Molecular18172068012092157177242307368388456486
Recognition23312068012061126190256323384404438458524585
of2943206801206697
Duplex30682068012074135203223288336
and34322068012068129198
Quadruplex36582068012087147216284314375443463528576
DNA42622068012074148222
by45122068012068122
Small46622068012049143212231251
Molecules49412068012092158178243307368388453492
and54612068012068129197
its568620680120205493
Application580720680120731422102302503153831817218801203454119180
for2025218801203197127
Developing21802188012074139195260280345413433494562
New27692188012074139222
Anticancer30192188012074135169189254322383448513543
Therapies35892188012043104169199268336356421460
Faculty7812341012248114178238262292350
Advisor11592341012274140196220264328360
Prof.1817234301205989154186213
Alaa2058234301207494162231
Eldin2316234301205474143163224
Salem25672343012050118138203297
Defense7812496012270134162226286330394
Date12032496012270136166230
2018172498012055111
May19552498012092161214
201521972498012055111166222
Abstract7812811012274140184214246312376406
Human1817281709655103178233282
telomeres21212817096257793146221273297349380
are252128170965579131
the267428170962574126
end2820281709652101156
caps2997281709651106161192
of320928170965278
linear33092817096143079131186210
chromosomes.3539281709652101125177252304335388463515546568
Under4127281709653102156208233
physiological4380281709655103146177193246262314368384436490506
conditions,4907281709652104153208224251267319368399421
telomere53502817096267894146221273297349
folds57212817096247692147178
up5919281709649104
into60452817096146390142
four621028170962375124148
stranded18172913096315882137186240292347
intramolecular21862913096116087111166241293309361413462478532557
structure27652913096265377126177204253277329
called3111291309652106122138190245
G-quadruplex.337329130967097151200254309333382436452504543565
Formation395529130963991115193247274290343392
of436429130965277
G-quadruplex445829130967097151200254309333382437453505543
has5018291309649103135
been5170291309654106158207
associated539429130965586117169221237292319371426
with583729130966682109158
inhibiting601729130961160109125179195222238287341
telomerase18173009096277995148223275299353384436
enzyme2273300909652101135178253305
found260030090962375124173228
enriched2848300909652100124140192241293348
in321830090961463
cancer3300300909652107156207259283
cells3603300909652104120136167
and3790300909655104158
involved397130090961362106159175219271326
in431930090961463
cells’4402300909651103119135167195
replications.461930090962273128144160212266293309362411442464
Subsequently,510530090963886141172224278327379428455471514536
G-quadruplex566130090967096151200254309333382436452504543
has6224300909648103134
become1817310509655107158211286338
an2177310509667116
active2315310509668119147163207259
target259631050964095119173225252
for287031050963890114
the300631050964089141
development3169310509668120164216232284339414466515542
of373331050966590
anticancer3846310509667116143159211265314366418442
agents.4310310509668121173222249280302
Small4635310509652127182198214
molecules4884310509675127143195247296312364395
stabilize530131050964471126180196212228262314
G-quadruplex5637310509683109164213267322346395449465517556
are621531050966791143
potential1817320109655107134186235262278333349
for218832010962679103
developing2314320109655107152204220272326342391445
anticancer2783320109654103130146198253302353405429
therapeutic323532010962877129153208262314363390406458
agents3716320109655109161209237268
acting4007320109655107134150199252
by428332010965597
inhibiting440332010961766115131185201228244293347
telomerase.47723201096298197149224276300355386438460
In181732970961867
this190632970964695111142
work,2070329709686139163203225
several2317329709651103147199223278294
new2633329709668120186
benzoquinone2842329709673125174208261315364380429481530582
derivatives3446329709674126150166211265292308353405436
were3904329709686138162213
synthesized414032970965093142169218270301317351403457
and4620329709674122177
their481932970964796148164188
structures502932970965077101150202229277302353384
were5435329709686138162214
elucidated567132970967187136188204259313340392447
using614032970966899115164218
elemental181733930965268120195247296323378394
analyses,2233339309669118172188231262314345368
IR,262333930963281103
NMR2748339309674148196
and2966339309670119173
MS.3161339309689128151
Benzoquinone3334339309660112161195248302351367416468517569
and3925339309669118173
its41203393096315889
synthesized423133930964688137164213265296312346398453
analogues4706339309669118173189241295344396427
were5155339309681133157209
studied538633930964673121176192244299
for570733930964092116
their584633930964190142158182
binding605033930967086134189205254308
affinity18173489096558099119168184211254
and2094348909654103158
selectivity227434890963284100152204231247291307334377
towards267334890962981148202226281312
telomeric30073489096288096148223275299315367
G-quadruplex339734890967097151200254309333382437453505543
DNA3963348909660119178
using41643489096498096145199
UV-Vis4386348909652108135191207238
absorption,4648348909654109140192216271298314366415437
fluorescence,51083489096203988140164216247299351400451503526
circular56573489096516792143191207262286
dichroism,596634890965571123172196248264295370392
melting1817358509675127143170186235289
temperature212835850962880156210262286341368417441492
and2644358509655103158
NMR.2826358509659132181203
The305135850963685137
results321035850962577108157173200231
indicated346335850961766121137189243270322377
that386235850962978132160
G-quadruplex404535850967096151200254309333382436452504543
DNA4611358509660119178
interacted48113585096186794146170224276303355410
with524535850966682109158
synthesized542535850963376124151200252283299333385440
compounds5889358509651104179233286334383438469
in181736810961665
stoichiometric190436810962956108124176225241293368420448472488539
ratios246636810962276103119172203
ranged269136810962277125179231286
in299936810961463
1:1308236810964466111
to321536810962577
1:4.331236810964567111133
Binding346536810964662111166182231285
affinities37703681096547999118167183210226278309
ranged410136810962277126180232287
between4408368109654106133200252304353
5.60x104478136810964466110155193237282326
-5129368109625
1.33x107517436810964466111155193238282326
M-1.5521368109673100144166
Compounds5707368109665118193247300348397452483
TQ86212368109632102146
and1817377709655103158
TQ61997377709634103148
showed216737770963079132198250305
the249437770962675127
best2643377709654106137164
stabilizing282937770963158113167183199215249265314368
effects321837770965277103155207234265
on3504377709653101
G-quadruplex362737770967096151199254309333381436452504542
with419137770966682110158
changes4371377709652100155204258310341
in473437770961564
melting4819377709675127143171187235289
temperature513037770962779154208260284339366415439491
(ΔTm)564337770962977112187216
of588137770965277
21598037770964488
and6090377709654103158
10626937770964589
αC,1817387309660125147
respectively.198638730962476107161213265292308352404420463485
In249438730961766
addition,2582387309654109164180207223275324346
synthesized295038730963174123150199251282298332384438
analogues3410387309655103158174226280329381412
showed384438730963179132198250305
good4171387309654106158213
selectivity44063873096318399151203230246290306333376
towards480438730962779146200224279310
G-quadruplex513538730967097151200255309333382437453505543
DNA5700387309659118178
over589938730965397149173
duplex6094387309654103158174226264
DNA.1817396909660120180203
Synthesized181740650964083132159207259290306340392447
compounds2285406509652104179234286335384438470
were2775406509667119143194
also299040650965571102154
tested316740650962577108135187242
against3430406509655109163179228259286
lung,373840650961564112166188
breast,394740650965579130185216243265
colorectal,4233406509652104120173197249300327382398420
prostate,467440650965579131162189244271323345
pancreatic,5040406509654109158209233285340367383435457
colon5518406509651104120172221
and5760406509654103158
lymphoma594040650961558133187236288363418
cancer1817416109652106155207259283
cell2122416109652104120136
lines.22804161096153180132163185
Loss248841610963689120151
in266141610961564
cells’2747416109652104120136167195
viabilities296441610964460115169185201217244260312344
in333041610961564
the341641610962776128
range356641610962478127181233
of382141610965277
25-100392041610964489115160204248
%4190416109662
with427441610966682110158
IC50’s445541610961782127171199230
between4707416109654106134200252304353
6.18508241610964466110155
and5259416109654103158
100.0543941610964488133155199
μM5660416109646120
were5801416109667119143195
reported601841610962375130182206233285340
for181742570962578102
synthesized194142570963982131158207259290306340392447
analogues2410425709663112166182235288337389420
after285242570966388116168192
24306642570965397
h3185425709657
relative326442570963385101155182198243295
to358142570963588
the369142570963584136
control.3849425709660113162189213265281303
These417442570964391143175227
results442342570963284115163179207238
revealed468342570963284128180235251303358
compounds5063425709660112188242294343392447478
of556342570966186
high567142570965773127176
potential5869425709663115142194243270286341357
for624842570963486110
further18174353096257498125174226250
processing209343530965478130182234265296312361415
as253443530965485
anticancer2645435309655104131147198253302354406430
therapeutic309743530963179131156210265317365392408460
agents.3583435309655109161209236267290
Research7374560017081171232322414459549633
Relevance14094560017081171204294372465549638728
and21764560017093177269
Potential24844560017079168210300384426459552585
Impact31094560017039170263355445487
Cancer737477709665120168220272296
is105547770962152
the112947770963281133
third12844777096328197121176
cause1482477709656111160191243
of174747770965782
death1856477709655107161189237
in211647770962069
UAE2207477709658117160
and2394477709654103158
worldwide.2579477709666119143159214280296351403425
Therefore302647770963988140164216241293317369
searching341747770963688142167218267283331385
for382447770963083107
new3953477709654106172
effective414747770965782107159211238254299351
and4525477709654103158
selective470547770963688104156208235251295347
anticancer5079477709655104131147198253302354406430
drugs553647770965479127181212
con-tinued5770477709657109158185212228276325377432
over6224477709657102154178
decays737487309655107159213256287
as104648730965586
a1154487309655
topic123148730962779134150202
of145548730965277
high155448730964965119168
importance174448730961691145198222249303352404456
in222248730961665
science.23094873096318399151200251303325
This26574873096348298129
work2808487309667119143184
revealed301448730962475120172226242294349
compounds3385487309652104179234286335384439470
of387748730965277
high397648730964965119168
potential4166487309654107134186235262278332348
for453748730962577101
further46604873096257498125174226250
pro-cessing493248730965479131157209261292323339388442
as539648730965485
anticancer5503487309655104131147199253302354406430
agents.5955487309655109161209237268290
The626748730963483135
study73749690963158107162204
combined966496909652105180234250299351406
molecular1397496909675127143195247296312366390
recognition180949690962779131183237286302329345397446
of228049690965277
G-quadruplex238249690967097151200254309333382437453505543
DNA2950496909659119178
and3153496909654103158
the333349690963079131
effect348949690965277102154206233
of374749690965277
synthesized384749690963376125152201253284300334386441
com-pounds4313496909651104179205260312361410465496
on4834496909652101
cancer4960496909651106155207259283
cells5268496909651103119135166
in-vitro.54574969096186794138154181205257280
Relevant7375116017081171204294372465549591
Publications13675116017078162255288322412504546580669753815
•737531309648
Alaa82953130965975130184
A.103553130965981
Salem,113953130963994110162237259
Ismail142053130961849124178194210
M.165253130967496
El177053130964258
Haty,1850531309655109136179201
Ibrahim20745313096177296150199215290
M.238653130967496
Abdou2503531309660114169221270
and2795531309654103158
Yaguang297553130964794148197251300354
Mu,3351531309673122144
Interaction35395313096176693145169224276303319371420
of398153130965277
human408053130964997172227276
telomeric43785313096277995147222274298314366
G-quadruplex478853130966996150199253308332381435451503542
DNA5352531309659118177
with555153130966783110159
thymoquinone:573253130962675118193245300349365413466515567589
A6342531309660
possible737540909655107138169185240256308
mechanism1066540909675127179228282331347378453
for154254090962476101
thymoquinone166554090962675118193245300348364413466514566
anticancer2253540909655103131147198253302354406430
effect.270454090965277103155206233256
Biochimica298154090964662115166215231306322374429
Biophysica345354090964662114169217260291307359414
Acta3910540909659111138193
(BBA),414654090962975121180210232
2015.440054090964488132177199
1850462154090964488133177
(2):482054090962973103125
p4967540909654
329-342.Career504354090964488133159204248292314379434458510562586
Career73755560170109202246336426470
Aspirations124755560170103165257291336428470504593677739
My737575309674116
dream87657530965478130185260
is115857530961647
to122757530962780
be1329575309654106
an1458575309654103
active1583575309655107134150194246
team185157530962779134209
player208257530965571125168220244
within234857530966783110159175224
an2594575309654103
academic2719575309655107161216268343359411
institution31525753096166596123139166215242258310359
to353357530962880
contribute3635575309652104153180204220275323351403
in406057530961665
the414757530962776128
education4297575309652107155207262289305357406
development.4725575309655107151203219272326401453502529551
On5298575309670119
the543957530962776128
other558957530965280128180204
hand,5816575309648103152207229
I6067575309618
would6107575309667119168184238
like7375849096163272124
to88358490962780
use98558490964980132
the113958490962776128
experience128958490965290145197221237289338390442
and1753584909654103158
skills19335849096317187103119150
that210558490962876131158
I2285584909618
have2326584909648103147199
gained2547584909654109125174226281
during2850584909655103127143192246
PhD311858490964796156
and3296584909655103158
Post3476584909648100131158
doctorate3656584909655108159186239263318345397
to407558490962779
synthesize417758490963173122149198250281297331383
new4582584909649101168
compounds4772584909652104179234286335383438469
that526358490962876131158
may5443584909675130173
help5638584909649101117171
in583158490961665
developing5918584909655107152204220272327343391445
anticancer737594509655103131147198253302354406430
therapies.118959450962776128152206261277329360382