419
306316470016778155
Maad73210840234177315452621
Shatnawi141110840234962443824856457789681020
Department7321298014981156232313348384495569643679
of14481298014975112
Intelligent1596129801492094130204224244263344419492528
Systems21611298014955114159195269380424
College7321442014989164183203277358433
of12021442014975111
Information1350144201492094130205240351432468488563636
Technology20231442014953109178247321396415490571631
Dissertation7311793017098132193255344389431524566599689773
Title73119880122426696120184
Protein1767199001205989155189254274335
Domain21291990012075140234302322383
Linker2540199001204666127177243273
Prediction:2840199001205990155223243308342362427488516
A33841990012074
Direction3485199001207595125190255288308374435
for3948199001203196127
Detecting41021990012075140174239303337357418486
Protein-Protein4615199001205989155189254274335368427457523557622642703
Interactions5346199001202283117182212280345379399465525564
Faculty7312143012248114178238262292350
Advisor11092143012274140196220264328360
Dr.17672145012074104125
Nazar19202145012074142184253283
Zaki22302145012048117167187
Defense7312298012270134162226286330394
Date11532298012270136166230
1017672300012055111
June19052300012049110170235
201521682300012056111166222
Abstract7312613012274140184214246312376406
Protein176726200964771123151203219267
chains2056262009651100155171220251
are232826200965579131
generally2480262009654106154206231285301317360
long286226200961568117170
and3054262009654103158
consist3233262009652105153184200231259
of351326200965277
multiple3612262009675123139167183237253305
domains.3938262009655108183237253302333355
Domains4315262009659112187241257306337
are467326200965579131
the482626200962675127
basic4974262009655110141157208
elements520426200965268120195247296323354
of557926200965378
protein567826200965579131158210226275
structure59752620096305781130182209257281333
that176727160962776131158
can1947271609664119168
exist,2137271609665103119150178200
evolve,2359271609665109161177222274296
and2677271609668116171
function287027160963887136188215231283332
independently.322427160962978133185239291340395447495523539581604
The385027160964796148
accurate4020271609667119171219243298325377
identification441927160962984136185212228247267319373400416469518
of495927160966590
protein507127160966892144171223239288
structural53812716096447195144196223271295350366
domains5769271609668120195250266315346
and6137271609667116171
their176728120962776128144168
interactions195728120962675102154178233285312328380429460
has2439281209659114145
significant260628120964157111160176195215266321370397
impacts3025281209626101156211262289320
in336828120962675
protein346528120966489141168220236285
research377228120963486117169223247298347
fields.414128120963050102118172203226
The438928120964493145
accurate4556281209665116168217241295323375
prediction495328120966488140195211263290306358407
of538228120966388
protein549228120966589141168220236285
domains5799281209665117192247263312343
is616428120962657
a6243281209665
fundamental176729080962574123177232307359408435490506
step229529080963764116171
in248829080962271
experimental258129080965897151203227243318370419446501517
and3120290809661110165
computational3307290809658110185240288316370397413466515569585
proteomics.391429080966185137164216269344360412443465
The440129080964089141
knowledge456429080964795148214230282337391443
of502929080965984
domains5135290809661113188243259308339
is549629080962253
useful557229080965486138163211227
in582129080962372
classifying591529080965874128159190206232274290339393
proteins,176730040965579131158210226275306328
understanding2117300409669118173225249280307361410465481530584
their272330040964796148164188
structures,293330040965279103152203230279303355386408
functions336330040964694143195222238290339370
and3755300409675124179
evolution,3956300409672117169185234261277329378400
and4378300409675124179
predicting457930040967599151206222273300316365419
protein-protein502030040967599151178230246295322376400452480532548596
interactions.563930040963685112164188243294321337390439470492
The6153300409654103155
identification176731000961671123172199215234254305360387403456504
of229431000966893
interactions240931000963280108160184238290317333386434465
among2897310009670145197246300
proteins321931000967094147174226242290321
and3563310009670119174
their375931000964391143159183
associated3965310009670101132184236252307334386441
structural44283100096477498147198225274298353369
domains4819310009670123198253269317348
provide519031000967094146190206261313
a5525310009671
global561831000966985138192247263
picture590331000967086138165214238290
of621531000966893
the176731960962776128
cellular1917319609659111127143192208262286
functions222631960963281129181208224277326357
and2605319609662110165
the279231960963584136
biological295031960966278130146198252268320375391
processes.336331960966286138190242273304356387409
In382331960962675
this39203196096348399130
research407231960963183114166221245296345
work4446319609667119143183
we4659319609666118
introduce479931960962472100124176231279331383
novel5204319609656109153205221
solutions544731960963891107155182198251300331
for580031960963285109
two5931319609634101153
main6114319609675129145194
research176732920962476107159213238289338
problems.212732920966387139194210262337368390
First,25393292096476387119146168
we2738329209666118
present287832920966387139170222271298
a3198329209663
method3292329209675127154203256310
for362532920963386110
the375732920963684136
prediction391632920966387138193209261288304357405
of434432920966186
inter-domain445232920962473100152176203258310385440456505
linkers49793292096244089129181205237
solely523832920963992108160176219
from547932920963458110185
the568632920963684136
amino5845329209663138154203255
acid6122329209663115131186
sequence176733880963183138186238287339391
information.21803388096146288140164241296323339391440462
This26653388096318096127
is281433880961445
achieved2879338809655107155171223268320374
by327333880965598
introducing33933388096146390114166221269321337386440
the385533880962573125
concept4000338809652105153205257312339
of435933880965277
amino4456338809655130146194247
acid4723338809654106122177
compositional4920338809652104179234286317333360376429477532548
index.549033880961463118170208230
Unlike5740338809652101117133173225
previous598533880965579131175191243292323
approaches,1767348409655109164188240295346395447478500
we2297348409667119
use243834840965788140
the260034840963584136
predicted275834840966286138193209260288340394
inter-domain31753484096237299151175202257309384439455504
linkers37013484096244088129181205236
to395934840963587
identify406834840962479131180207223248291
the438134840963584136
actual4539348409663114142190245261
structural48223484096396690139191218266290345361
domains.5205348409663115190245261310341363
Second,5590348409648100152204253308330
we5950348409666118
utilize609034840965784100116132166218
the176735800962776128
structural191735800965481105154205233281305360376
domain2315358009678130205260276325
knowledge2662358009663111164230246298353407459
to3143358009650102
predict3268358009677101153207223275302
protein-protein3592358009678102154181233249298324379403455482534550599
interactions.421335800963988115167191246297325341393442473495
The4730358009657106158
proposed4910358009677101153208260291343398
framework533035800964872127202254320373397437
is578935800963970
evaluated5881358009675119174190239293320372427
against1767367609655108163179228259286
several207536760963082127179203257273
state-of-the-art237136760963057112139191217270295321348397449476530555582
approaches2974367609654109164188240294346395447478
and3473367609655104159
demonstrated3653367609655107182234283314341365420447499554
that422936760962675129157
it440836760961542
provides447136760965579131175191246298329
a4821367609655
noticeable4897367609649102129145196248303358374426
improvement.534536760961590145169221265317392444493520542
The590936760963482134
higher606536760964864118167219243
accuracy1767377209655106158207231286337380
achieved2169377209663114163179231275327382
is257337720962455
a2650377209663
valid2735377209652106122138193
argument295037720966387141189264316365392
in336437720962473
favor345937720963387132184208
of368937720966085
the379737720963483135
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framework.436037720963256111186238305357381421443
Keywords:1767386609750101147211262288341376398
Protein218838680965983135162214230279
domain2489386809666118193248264313
identification,282438680962782134183210226246265317371399415467516538
domain-linker3384386809666118194248264313340356372420460512537
prediction,394338680966690141196212264291307359408430
compositional4395386809664116191246298329345372388440489544560
index,497738680962776131183221243
physiochemical5243386809665114157188204257308357409484500552607623
properties,588838680966690142196248272300316368399421
protein-protein176739640965579131158210226275301356380432459511527576
interaction236539640962977104156181235287314330382431
prediction,281839640966892143198214266293309361410432
PPI,3273396409659107125147
domain-domain3442396409668120195250266314341396448523578594643
interactions.410739640962877104156180235287314330382431462484
Research6874114017081171232322414459549633
Relevance13594114017081171204294372465549638728
and21264114017093177269
Potential24344114017079168210300384426459552585
Impact30594114017039170263355445487
The68743310963483135
identification84443310962075127176203219238258310364391407460509
of137543310965681
protein-protein148343310965478130157209225274301355379431459511527575
interaction20814331096206896148172226278305321374422
is252643310962051
crucial259943310965680128180196251267
to288843310963184
the299443310963180132
understanding3148433109653101156208232263291345394449465514567
of373843310965681
the384143310963280132
molecular4000433109675127143195247295311366390
events4412433109656101153202229260
under4694433109653101156208232
normal4948433109653106130207262278
and5252433109655103158
abnormal5437433109654109158210234311366382
physiological5845433109655104146177193246262314368384436491507
conditions.687442709652104153208224251267319368399421
It113044270962250
leads120244270962072126181212
to143644270963184
significant154244270963551105153169189208260315364391
applications1959442709655109164180196247302329345398446477
for245944270962981105
the258644270963180132
diagnosis274444270965571126179228281312328359
and3129442709654103158
treatment330944270963155107162189264316365392
of372744270965277
diseases383044270965571102154209240292323
such417544270963584136184
as438544270965586
cancer4493442709656111159211263287
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diabetes499144270965470125180232259311342
which5359442709666115131183232
are561744270965579130
relevant57694427096288096148192247296323
to611444270963184
the622044270963180132
UAE.687452309652112156179
Relevant6874670017081171204294372465549591
Publications13174670017078162255288322412504546580669753815
•687486709648
Maad792486709669123178233
Shatnawi104248670964089143170219274340356
and1416486709654103158
Nazar1591486709659114148202227
Zaki183548670963893133149
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Inter-domain22604867096136289141165191246299374428444493
linker27754867096112776116168192
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using33994867096498096144198
amino3615486709654129145194246
acid3879486709654106122177
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index.464348670961160115167205228
Computational4888486709665117192247296323377404420473522576592
Biology549748670964662115131183237280
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Chemistry5970486709665113165240256287315339382
(CBAC)77649630962994140199264294
55:109249630964489111
23-122549630964489115
30,136249630964589111
April1495496309660114138154170
2015.168749630964589133178200
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IF203749630961856
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•687505909648
Maad802505909673128183238
Shatnawi,106250590964088143170219274340356378
Nazar1462505909660114148203227
Zaki,171150590963893133149171
and1905505909654103158
Paul2085505909647102151167
D.227450590965981
Yoo237850590964792145
(2014)254550590962974118162207236
“Protein280350590964088112164191243259308
inter-domain31335059096166592144168195249302377431447496
linker36515059096163281121173197
prediction387150590965478130185201252279295348397
using42905059096487995144198
random451050590962479128183235310
forest484250590962578102153184212
and5076505909654103158
amino5256505909655130146195247
acid5525505909655107123177
physiochemical5724505909655104147178194246298347399474490542596612
properties.”79851550965478130185237261288304356387409448
BMC1268515509646120185
Bioinformatics147551550964662114130179204257281358412440456507538
15203651550964488
(Suppl214651550963070118173227243
16):241251550964488118140
S8,257451550964084106
December2703515509659111163215290344396421
2014.314651550964488133177199
(ISI33675155096304888106
IF349551550961857
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Shatnawi105752510963988142169218273339355
and1433525109655103158
Nazar1612525109659114148202227
Zaki186152510963791131147
(2015)203152510962872116161205234
Novel2286525109659112156208224
domain2531525109655107182237253302
identification285552510961469121170197213233252304358386402454503
approach3378525109655110164188240295347396
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interaction45155251096146390142166221272300316368417
prediction.495252510965579131186202253280296349398420
2015539252510964589133178
IEEE559252510961760102145
Conference5758525109665117166191243267319368420472
on6250525109653102
Computational798534709665117192247295323377404420473522576592
Intelligence14125347096186794146162178194248300349401453
in188753470961665
Bioinformatics197453470964662114130179204257281358412439455507538
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Computational2715534709665117192247296323377404420473522576592
Biology,332953470964662115131183237280302
Niagara365353470965975130184238263317
Falls,399253470963994110126157179
Canada,4193534709665120169223278333355
August4570534709659108162210241269
2015.486153470964488133177199
Career68754940170109202246336426470
Aspirations119754940170103165257291336428470504593677739
To68756910963483
have792569109649103147199
an1014569109654103
academic1139569109655107161216268343359411
position1572569109655107138154181197250298
within189356910966682109158174223
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institution,26205691096166596123139166215242258310359381
to302356910962880
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an3254569109654103
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team364756910962880134209
player387856910965571126168220245
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research500656910962476107159214238289338
groups,536656910965478130178233264286
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knowledge68757870964089141208224276331384436
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