389
346316470016778155
Amna6609520234138315475608
Eissa13269520234108160256352489
Al18749520234137246
Baloushi21789520234116246355512662758906958
Department6601166014981156232313348384495569643679
of13761166014975112
Medical152411660149110184265285353434454
Microbiology201511660149109129198233294366386461481556637696
and27481166014981155235
Immunology30201166014920131242317390465485560641701
College6601310014989164183203277358433
of11301310014975111
Medicine127813100149110184264284353373446521
and18351310014981155236
Health21071310014974148229248285354
Sciences24981310014954123142217290359433478
Dissertation6601598017098132193255344389431524566599689773
Title66017930122426696120184
Characterization16971795012081142210240309373407472502522565633667687753814
of2538179501206697
carbapenemase26631795012065133163231299368433494559652721760825
producer3515179501206899164233293358423453
Enterobacteriaceae39961795012053115148213243309377445510544609639659727792857925990
isolated5014179501202059124144213247312380
in5422179501202081
the5531179501203494159
United57181795012066127147181246314
Arab16961915012074104172241
Emirates19641915012054148168198266300365404
Faculty6602120012248114178238262292350
Advisor10382120012274140196220264328360
Dr.16962122012074105125
Agnes18492122012074141202267306
Sonnevend-Pál21822122012050116177238303358423484553586645713733
Defense6602275012270134162226286330394
Date10822275012270136166230
2216962277012055111
June18352277012048109170235
201520972277012056111166222
Abstract6602590012274140184214246312376406
Theefficient169625960963483135200225244264316332384432459
control2168259609652104153180204256272
of245325960965378
the254425960962776128
spreadof268425960963286110162216271337362
carbapenemaseproducer305925960965110613018523929434639544752257660765972775180385890695810101034
Enterobacteriaceae,410625960964392119171195247301356408435487511527582633685740792814
amajor4933259609655143197214266290
public5236259609654103158174190241
health5490259609649101156172199248
threat575125960962775100151206233
worldwide,5997259609666119143159214169626920966682137189211
requires193026920962172127176192216267298
knowledge224826920964089141208224276330384436
on2703269209653102
the282726920962473125
molecular2971269209675127143195247296312366390
epidemiology3381269209652106122177229304320372388441495538
and3938269209654103158
genetic4115269209654106155207234250302
background4436269209655109161201255279331380429483
of493926920965277
the503826920962473125
emerging5182269209652128180204257273322376
carbapenemase5577269209652107131185240295347395447522577608660
genes.1696278809654106155207238260
Our1978278809689137161
aim216227880967389164
was2349278809685140171
to254227880964699
investigate266327880963584128180211238254308363390442
the312727880964695147
genetic3296278809673125174226253269321
support363927880965099154208261285312
of397327880967197
New-Delhi4092278809678130197223283335351399415
metallo-beta-lactamase4530278809694146173228244260312339393445472527553569624676703758833887918970
and5522278809674123178
OXA-48-type5722278809689138197223268312338366408463515
carbapenemase1696288409652106130185240294346395447522577608660
genes2378288409663115164216247
in264728840962675
carbapenem2744288409661116140194249304356404456531
resistant329828840963385116132163190245293321
Enterobacteriaceae3641288409652101128180204256311365417444496520536591643695749801
isolated446528840962556108124179206258313
in480028840962675
the489728840963685137
United5056288409662111127154206261
Arab533928840966993147202
Emirates.5563288409653128144168222249301333355
The594028840964392144
first61062884096294973104131
seven169629800963183127179228
NDM-producer1946298009670129203229284308360415463515567591
Enterobacteriaceae,2559298009653102129181205257312366418445497521537592644696750802825
collected3406298009661114130146198250277329384
during3812298009664113137153202256
2009-2011409029800965499143187214258302347391
in450329800962675
the460029800963886138
UAE4760298009663122165
and4947298009665114168
subsequently513729800964290145176228282331383432459475518
five56772980096294993145
NDM5844298009670129203
and6069298009664113168
OXA-48-type1696307609670118177204248293319346389444496
carbapenemase2217307609651106130185239294346395447522576607659
co-producer2901307609652104131185210262316365417469493
Klebsiella341630760965066118172203219271287303358
pneumoniae3799307609655103155204279331380396451503
isolated432430760961950102118173200252307
during4655307609655104128144193247
2011-2013492430760964791135180206251295339384
in533030760961867
three541930760963079103155207
hospitals5648307609651104135189205232287303334
of600730760965277
the610730760962978130
Emirates,1696317209643118134158213240292323345
were2069317209666118142194
characterized.2285317209658106161185240291319371395411445497551574
Strains’28813172096457296151167216247275
clonality317831720965874126175229245261289331
and3532317209660109163
the371831720963281133
transmissibility387331720963357112161192267283314345361415431447463491533
of442931720965883
carbapenemase4534317209657112136191245300352401453528582613665
genes5221317209660112161213244
were5493317209666118142194
assessed.570931720966091122174205236288343365
The609731720963988140
genetic1696326809654106155207234250302
support202032680964392147201254278305
of234732680966590
carbapenemases2459326809665120144198253308360408460535590621673704
was3185326809680134165
studied337232680964471120175191243298
by3692326809667110
characterization3824326809665114168192247299326378402418452507534550602651
of449732680966590
plasmids460932680966884138169245261315346
and4978326809667116171
by5171326809667110
sequencing530332680964496151199251300352368417471
the579632680964088140
genes’5959326809666118167219250278
surrounding.169633640963180104128180229277332348397451473
All219133640967591107
isolates232033640963263115131186213265296
harbored2638336409665119144198250275326381
the304133640964392144
blaNDM-1320733640967086141200260333360404
gene3633336409670122170222
on3878336409668117
conjugative4017336409667120168185233287342369385429481
plasmids.452033640967187141172247263318349371
Furthermore,4913336409655104128155204256280357409433485507
IncX3544233640963483135183228
plasmids569233640967086141172247263318349
with606333640968298125174
almost169634600965571146198229256
identical197434600962176128177204220272327343
restriction233934600962981112139163179231258274326375
patterns2741346009655109136164216240290321
were3089346009667119143195
present331134600965478130161213262289
in362234600962170
Enterobacter371434600964897124176200252307361413440492516
cloacae,425334600965672125179231286338360
Escherichia463534600964879131180232256272324372388443
coli5100346009657109125141
and5269346009654103158
Citrobacter545434600966581108132184239294345373425449
freundii.592534600963054106154203258274290312
The169635560963483135
NDM1853355609672132206
plasmid208135560966884138169244260315
of241835560966691
one2531355609666115167
K.272035560966083
pneumoniae,2825355609668116168217292344393409464516538
harboring3385355609662117141196248272288337391
blaOXA-48379835560966884138208257316342387431
also,425135560966884115167190
was4463355609680134165
almost465035560966884159212243270
identical494235560962984136185212228280335351
to531535560964093
these543035560964089141172224
IncX3567635560963180132181225
plasmis.592335560966884139170245261292314
Three169636520963483107159211
of193236520965277
the203136520963079131
five21843652096224286138
double2347365209655107156211227279
carbapenemase2651365209651106130185239294346395447522576607659
producer333536520965579131186235286338362
ST14372036520964276121165
K.390736520965072
pneumoniae4004365209655104156204279332381397451503
possessing4532365209655107138169221252283299348402
blaNDM-1495936520965571125184244317344388
and5372365209655104159
blaOXA-232555636520965470125194243302329373417462
were6043365209666118142194
clonally169637480965268120169224240256298
related.201737480963385101155182234289311
The235137480964392144
fifth,25173748096294873100149171
unrelated2710374809658107131183199253280332387
K.311937480965779
pneumoniae3220374809664113165213289341390406460512
co-produced3755374809660113139194218270325374425477532
NDM-14309374809669128202228273
and4604374809664113167
OXA-162.4803374809669118177204248292337359
These518437480964392144175227
findings54333748096294997152168217271302
proved575737480966488140184236291
that607037480963785140167
IncX3169638440961867119167212
plasmids193238440965571126157232248302333
play229038440965571125168
an2483384409655103
important260838440961994149201225252307356383
role30133844096267894146
in318238440961867
the327138440963078130
inter-species34243844096186794146170197228282334386402454485
spread393138440963488112164219273
of422938440965278
the432938440962978130
blaNDM448438440965470125184244317
gene,4826384409654106154206229
and5079384409655104158
also526238440965571102154
that543838440963079133160
the562138440962978130
emergence5776384409652127179203257309357409461
of169639400965278
NDM-1795394009659118192218
and2034394009655104159
OXA-48-type2214394009669118177204248292319346389443495
carbapenemase2731394009651106130185239294346395447522576607659
co-producer3411394009652105131186210262317365417469493
K.392539400964770
pneumoniae4016394009654103155204279331380396450502
is454139400961546
partially4608394009654109133160176231247263306
a4935394009654
clonal501039400965268121169224240
phenomenon5271394009655103155204257332384432485534
in582739400961563
the591339400962674126
UAE.6060394009653112155177
Since169640360964056105156208
the192740360962574126
carbapenemase2073403609652107131185240294346395447522577608660
producer275340360965579131186235286338362
Enterobacteriaceae313640360964391119171195247301356408435487511527581633685740792
are394840360965579131
extremely409940360965291118142193268320336379
drug449940360965579127181
resistant,470240360962374105121152179234283310332
leaving505640360961567121166182230284
few536240360962476142
treatment552640360962650102156183258310359386
options,5933403609652107134150202251282304
the169641320962776128
efficacy184641320966388108127179234286328
of219741320966388
alternative230841320966682109161185235290317333377429
antimicrobials2759413209666115142158233249301325377432448503519550
was3331413209678132163
also351641320966682113166
assessed370441320966697128180211242294349
by4075413209666109
testing420641320963991122149165214267
the449641320963887139
effect465741320966388114166217245
of492441320966389
the503541320963887139
himenochirin-1B519641320966076151203252304356405421445461510536581627
analogue5845413209666115169185238291340392
antimicrobial1696422809655103131147222238289313366420436491507
peptide2225422809679131186213229284336
on2583422809677126
selected2731422809655107123175227254306361
strains311442280965683107162178227258
and3394422809679128183
the3599422809652100152
fosfomycin3774422809649102133158210285328380396445
susceptibility4241422809656104135187239294321337391407423439466509
of4772422809678103
454897422809669113
carbapenem5032422809677131155210265319371420472547
non-susceptible5601422809674126175201232281312364416470497513568584636
Escherichia169643240964374126174226251267318367383438
coli2156432409669121137153
isolates.233143240963364116132187214266297319
The267343240965099151
[E6k,D9k]hymenochirin-1B2846432409645881321731952542993393674164595345866346877397878038278438929199631009
showed387743240964897149216268323
high422243240966581135184
potency4428432409672124151203252304347
against4797432409671125180196244275303
all512243240967187103
selected5247432409648100116168220247299354
NDM-producer.5623432409676136209236290314367421470522574598614
Furthermore,169644200963987112139187239264341393417469491
fosfomycin220944200964194125150202277320372388437
could2668442009668120169185240
be2930442009671123
a3075442009671
valuable3168442009661115131180234289305357
therapeutic354744200964492144168223278330378405421473
option4042442009669123151167219268
against4332442009671125179195244275302
carbapenem-resistant4656442009668123147202256311363412464539565589641672688719746801850877
E.555544200965981
coli,5658442009668121137153175
since585544200964763112164216
the609344200964392144
susceptibility169645160963180111162214269296312367383399415442485
of220345160966085
all23104516096627894
isolates242645160962455107123178205257288
tested273645160963587118145197252
was3017451609667121152
retained.319245160963183110165181229281336358
Research6174707017081171232322414459549633
Relevance12894707017081171204294372465549638728
and20564707017093177269
Potential23644707017079168210300384426459552585
Impact29894707017039170263355445487
Ms.617490409674105127
Baloushi’s764490409646101117169218249298314342373
research115949040962274105157212236287336
set151749040962981109
the164849040962574126
UAE’s1794490409653112155183214
experience202949040965290145197221237289337389441
with249149040966682109158
carbapenem2670490409651106130185239294346395447522
resistant321449040962274105121152179234283310
Enterobacteriaceae,354449040964392119171195247302356408435487511527582634686740792814
into43814904096146390142
a4544490409654
global461949040965470122177231247
context.4887490409652104153180232270297320
The522949040963281133
molecular5382490409675128144196248296312367391
investigation579549040961463108160191218234288342369385438487
of61750000965278
multi-drug719500009675124140167183210265289337391
resistant113250000962779110126157184239287315
organisms147150000965377131185234250281356387
highlighted188150000965167121170186202256304332384438
the234150000963079131
mode2497500009675127182234
of275650000965378
spreading285650000963488112164219273289338392
of327350000965277
these337350000962978130161213
bacteria.3611500009655109161188240264280335357
Furthermore,399050000964291115142191243267344396420472494
she450650000963483135
proved466650000965478130175227282
that497050000963078133160
fosfomycin515250000962881112137189264307359375424
could5601500009651104152168223
be5849500009655107
a5981500009654
useful605750000965283135160209225
option617509609652107134150202251
for89050960962679103
the101550960962876128
treatment116650960962751103158185260312361388
of157750960965277
carbapenem1677509609652106130185240294346395447522
resistant222150960962577108124155182236285312
Escherichia257850960964475127175227252268319368384439
coli3040509609651104120136
infections.32215096096166590142194221237290338369392