316
128606074012055111
Title523190801344673106132202
CHIRAL15031812018873159202275348416
SEPARATION19421812018861135202267341414475518597677
AND26421812018874153232
QUANTITATION29021812018879159232312379422489556617660740819
OF37491812018879152
KHAT39271812018873159232293
DESIGNER42481812018879153214257336415489562
DRUG48381812018879153232311
–51771812018855
SYNTHETIC52591812018862129208275361434502544618
CATHINONES15031942018873147208294336416495575648709
–22401942018855
IN23221942018843122
URINE24721942018879153195275348
AND28441942018873153232
PLASMA31041942018867134207268366440
Faculty5232184013453125196262288321385
Advisor9392184013481154215242290361396
Dr.15032180013875114133
Mohammed16702180013885145206264356449507567
A.2272218001386699
Meetani24062180013884142200237295356381
Defense5232415013477147178249315363433
Date9872415013477150183253
1015032411013860120
November16582411013873133187244336397455494
201621872411013860120180240
Abstract7503949013481154202235271343414447
This15032595013864126151200
dissertation1737259501386186135184242282318376413438498559
is2331259501382574
concerned24392595013851111172223281320381439500
with29742595013881106143205
the3213259501383798156
latest3403259501382683120178227264
class3701259501385176134183232
of3967259501386095
the4096259501383798156
new42872595013861119200
designer45222595013861118168193254315373412
drugs49692595013860100161222271
(NDDs)52752595013842115190264313355
which56652595013882143168219280
overruns59802595013859113170210249311372421
the6436259501383698156
world15032745013882141181206267
in1804274501383192
the19312745013842103161
last2127274501383188137174
few2335274501384198180
years25492745013860117175215264
as28472745013864113
“legal2994274501385075133194251277
high”3305274501386792153214258
drugs,35982745013866106167228277310
under39432745013867128189247286
the42642745013842103161
name44602745013867124217275
of47692745013865100
bath49042745013866124161222
salts51602745013855113138175224
or54182745013866105
synthetic55582745013854109170207269326363388439
cathinones.60322745013856114150212237298358419477526560
Bath15032895013865123160221
salts17592895013856114139176225
are20182895013865105162
a22152895013865
group23142895013868108167228289
of26372895013867102
central27742895013858116177214253309334
nervous31432895013868126166221280341390
system35672895013857111160197255347
stimulants3949289501385693118211272297355416453502
that44862895013843105162199
consists47202895013858117179228253302339388
mainly51502895013892150175236261316
of55012895013866101
synthetic56372895013856111172209270328365390441
cathinone61122895013858116153214239301360422480
derivatives.15033045013861119158183238294331356411468517550
In2087304501383596
nature,22103045013862119156217257314348
cathinone25923045013844102139200225286346408465
(β-keto3092304501383596136191248285344
amphetamine)34643045013858150211272330367425517542604661704
exists41953045013858112138187223273
in4502304501381880
the4616304501383091149
leaves4800304501381876134188245294
of5122304501385994
the5251304501383091149
Catha54283045013866123160222279
edulis57353045013858119180205230279
plant6042304501386186144205242
which63113045013882143169219281
can15033195013851108170
be17073195013868126
found18673195013842101162224285
easily21863195013865122172197222277
in2497319501383294
the26253195013844105163
region28223195013847104165190250312
of31683195013867102
northeast33043195013868128168204266324381430467
Africa38063195013873108147172223280
and41213195013865126187
the43423195013844105163
Arabian45403195013873112168229254312373
Peninsula.49483195013867122184209270319381406464497
All5479319501387398124
synthetic56373195013856111172209271328365390441
cathinone61123195013858116153214239301360422480
derivatives15033345013861119158183238294331356411468517
contain20543345013858118179216274299360
a24493345013864
chiral25483345013857119144184239265
center28473345013858116177214272311
and31933345013865126187
most34213345013893152201238
probably36943345013867107166227285346371426
sold41543345013856116141202
out43903345013867128165
as45903345013864113
a47383345013865
racemic48373345013847103153211304329379
mixture.52583345013892118172209270310367400
Commonly,56933345013873133225317377439464519542
one62693345013867129186
of64903345013867102
the1503349501383798156
enantiomers16933495013869130188250286312371464522561610
will23383495013892117142168
have25403495013872130184241
greater28163495013871111168226263321360
psychological32113495013871120175225286346371431492517568626651
effect38963495013869104138195245282
in4213349501383697
human43453495013872133225283345
biological4724349501387197156181241302327378436461
system52193495013860115164200258351
than56043495013848109167228
the58673495013847109166
other60683495013870107169226266
one.63683495013871132190224
Therefore15033645013864126183223280315374414471
it’s200936450138225983129
important21723645013822115176235275312369431468
to2674364501383494
distinguish2802364501385883133169194256317378403452514
between33503645013858116153234292350411
synthetic37963645013846101162199260318355380431
cathinone42613645013848106143204229291351412470
enantiomers.47653645013855117174236273298357450508547596630
Enantiomeric54293645013859120178240276301361454511551576627
separation60903645013847105165223263319355381440502
and15033795013858119180
determination17133795013861119155213253345371432490526552611673
of2420379501385691
these2545379501383294152201259
NDD’s28343795013873148222246291
may31553795013893151205
give3390379501386186140197
information3622379501382182117176215308366402427487549
about42053795013853114174235272
the4512379501383293151
source46983795013845104166205256313
of5046379501385590
these5171379501383294152201258
synthetic54643795013845100161198259317354379430
drugs59243795013861100162222272
and62303795013853115176
the6440379501383294152
raw1503394501384096177
materials17173945013892150187245284309367392441
that21933945013839101158195
were24253945013882140180237
used26963945013865114171232
in2963394501382889
the30863945013840101159
synthesis32803945013851106168204266324373398447
process37613945013864104163213271320370
and41653945013861122183
also4382394501386186135195
facilitates4611394501383894145170195221257315352410459
the51043945013840101159
drug52983945013863103164225
tracking.5558394501383979135185240265327387421
The15034095013864126183
main17154095013892150175237
objective19804095013860120152209260297322377434
of2442409501386095
this2571409501383193118167
dissertation2766409501386186135184242282319376413438498559
is3360409501381968
to3463409501383090
develop35814095013861119174231256316377
and39864095013858119180
validate42004095013849105130155216274311368
sensitive46034095013843101162211236273298353410
and50424095013857119180
selective52564095013843101126184235271297351409
analytical56934095013858119177202257294319369427452
methods61744095013892150187248308369418
that1503424501383798156193
use17304245013869118176
direct1941424501386994133191241278
and22534245013866128188
indirect2476424501383394155180220277328365
chiral28754245013859120145185241266
separation31754245013857115176234273329366391451512
and37224245013865127188
quantitation39444245013869130188249286311348406442468527589
for45674245013843102141
synthetic47434245013857112173210271329366391442
cathinones52194245013859116153215240301361422480529
in5783424501383394
real59124245013847104162187
biological6134424501386894153178238299324375433458
samples15034395013849107199260285343392
using19254395013862111136197258
chromatography22174395013847108148207299357394454515554610671732786
coupled30374395013847107168229254312373
with34404395013881107143205
mass36754395013892150199248
spectrometer39584395013844105163214251290350442500537594634
detector46224395013861119156214264301361400
(MSD)50574395013838123184259301
and53924395013854115176
Diode55984395013874100159220278
Array59064395013866106145201255
detector61914395013861119156214264301361400
(DAD).15034545013842117182257299332
The15034695013864126183
study1721469501385592154214269
goals20254695013867126184209258
were23184695013888146185243
achieved25954695013864115177202260314371432
successfully30624695013855116167218275325374409469494520574
by36714695013867122
developing38274695013867125180237262322383408469530
and43924695013864125186
validation46124695013861117142167228286323348408469
of51154695013866101
three52514695013843104144201259
different5545469501386792127162218258315377413
methods59994695013893151187249309369418
for64524695013841100140
chiral15034845013851112137177233258
separation17954845013852110171229268324361386446507
and23374845013860121182
quantitation25544845013863125182244280306342400437462522583
for3172484501383796136
6533424845013866129
compounds35054845013854114206267327388449510559
of4099484501386297
synthetic42304845013852107169205267324361386437
cathinones.47024845013853111148209234296355417475524557
Enantiomer52934845013865126184245282307367459517557
quantitation58844845013864125183244281306343401438463523584
in6502484501382890
urine15034995013861101126188245
and17834995013864125186
plasma2003499501386792150199291349
were23934995013881139179236
performed26644995013867124164199258297390448508
and32074995013864125186
reported34274995013846103164224264300358419
for38804995013842100140
the40544995013843105162
first4251499501383565104153190
time4475499501384369161219
in4728499501383293
this48554995013843105130179
study;5068499501385592154214269308
also5410499501386490139198
it’s564349950138316892138
the58154995013843104162
first6011499501383665105154191
time6236499501384368161219
to64894995013843103
report1503514601384097158218257294
the18315146013845107165
chiral20305146013859120146185241266
separation23315146013857115176233273329366391451512
of28775146013868103
tertiary30155146013845103142179204262302356
amine34065146013866158184245303
cathinones37435146013859117154215240302361423481530
where43075146013890151209249306
we46485146013890147
were48305146013890148187245
able51095146013866127152210
to53535146013845105
separate54935146013857115176233273329366424
1959515146013871134
out61205146013868129166
2263205146013871134
of64895146013868103
them.15035296013837100159253287
RASHED6626950243116264368504608748
HUMAID14666950243136264444592648788
AHMAD23106950243148284464612752
KHALFAN31186950243124260408496592740888
BIN6629150243116172320
HUZAIM10389150243136264364512568748
ALREMEITHI1842915024314823635245663674079688010161072
Department6621154014684161240319358394506583655691
of13871154014677110
Chemistry15311154014693165242355384437473511581
College6621314014694170199228305384461
of11561314014677111
Science13001314014663140168245317394471
Dissertation4821643017098132193255344389431524566599689773