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SHAIKHA SAIF SAEED ALNEYADI
Department of Chemistry
College of science
Title
Design, Synthesis And Biological Studies Of Some Novel Pyrimidine Derivatives
Faculty Advisor
Dr. Ibrahim M. Abdou
Defense Date
19 May 2016
Abstract
Increasing incidence of diabetes and antimicrobial resistance are considered of the most common concerns
in the medical field. This research is aiming to design, synthesize and biochemically evaluate some novel
pyrimidine derivatives for potential remedies in combating diabetes Type 2 and common pathogenic
bacteria. Pyrimidine derivatives were synthesized and its structures were elucidated using the most recent
spectroscopic techniques. The preliminary results indicated that some of the synthesized pyrimidines
represent valuable anti-diabetic activities and showed a good starting point for the design and discovery
of small-molecule GLP-1 agonists that can be administered orally, while other derivatives were able to
activate PPARγ and enhance insulin sensitivity.
The antibacterial activities exhibited promising results with better IC50 values compared to some common
antibiotics. To confirm the antibacterial activity, the interaction between selected compounds and
β-lactamase enzyme was studied using FT-IR, NMR, UV-Vis., fluorescence, TEM, and CD techniques and
molecular docking.
Dissertation