The Department of Anatomy makes significant contributions to mission of the College of Medicine & Health Sciences in the areas of education, research and service. The Department currently has 7 academic staff members and 8 support staff and several postgraduate students. Academic staff members are involved in cutting edge research with strong collaboration with their counterparts at both national and international institutions. A major focus of our teaching is the application of morphological sciences in the clinical setting.
The Department facilitates the Anatomy Dissecting Laboratory, a key teaching facility for the training of medical students in Gross Anatomy. The Dissecting Room caters for undergraduate as well as postgraduate medical students. It is opened to students after regular classes.
The Department show considerable strength in the fields of neuroscience, stem cells, cancer, diabetes mellitus, scoliosis, epigenetics and structure/function relations. In addition to histological, TEM and SEM, immunocytochemistry and immunoelectron microscopy techniques, contemporary methods in molecular biology are being used by faculty members in Anatomy Department.
Research Facilities located within the Department include:
- Transmission electron microscope (2)
- Scanning electron microscope (1)
- Confocal laser microscope (2)
- Fluorescence microscope (2)
- Tissue culture unit (1)
- Tissue sectioning appliances such as cryostat, vibratome, microtomes.
- Tissue embedding unit, and many others.
The Anatomy Department teaches all aspects of the morphological sciences, primarily in the first four years of the curriculum. During years one and two, Anatomy Department contributes to the Premedical and Preclinical Programs. In the first year, General Human Biology, Cytology and Histology and the topography of the Thorax and Abdomen are examined. In year two, the Anatomy of the Pelvis, Perineum, Upper and Lower Limbs, and Head and Neck are studied. In the Preclinical Program taken in years three and four, the Department contribute to the Mechanism of Malignancies and Oncology, Cardiovascular, Respiratory, Water and Mineral balance and Excretion, Nutrition and Metabolism, Growth and Reproductive, Musculoskeletal and Neuroscience and Special Senses Courses. We teach the histology and embryology, and review the gross anatomy of the organ systems of the body at this time.
The Anatomy Department also takes part in Problem Based Leaning and in clinical teaching by providing expertise in multidisciplinary seminars.
In addition to undergraduate medical programs, the Department also offers courses in Principles of Research, Developmental Anatomy, Medical Tissue and Cell Biology, Advanced Cell Biology, Techniques in Morphological Sciences to Masters and PhD students.
Articles in Peer-reviewed Journals
- Adeghate E, Singh J (2014). Structural changes in the myocardium during diabetes-induced cardiomyopathy. Heart Failures Reviews; 19:15-23.
- Lotfy M, Singh J, Rashed H, Tariq S, Zilahi E, Adeghate E (2014). Mechanisms of the beneficial and protective effects of exenatide in diabetic rats. Journal of Endocrinology; 220:291-304.
- Lotfy M, Singh J, Rashed H, Tariq S, Zilahi E, Adeghate E. (2014). The effect of glucagon-like peptide-1 in the management of diabetes mellitus: cellular and molecular mechanisms. Cell Tissue Res; 358:343-358.
- Adeghate E, Fehér E, Kalász H (2015). Evaluating the Phase II drugs currently under investigation for diabetic neuropathy. Expert Opinion in Investigational Drugs; 24: 1-15.
- Lotfy M, Adeghate J, Kalasz H, Singh J, Adeghate E (2017). Chronic complications of diabetes mellitus: A Mini Review. Current Diabetes Reviews; 13: 3-10.
- Adeghate J, Nurulain S, Tekes K, Fehér E, Kalász H, Adeghate E (2017). Novel biological therapies for the treatment of diabetic foot ulcers. Expert Opinion on Biological Therapy; 17 (8): 979-987.
- Mahgoub MO, D'Souza C, Al Darmaki RSMH, Baniyas MMYH, Adeghate E (2018). An update on the role of irisin in the regulation of endocrine and metabolic functions. Peptides; 104:15-23.
- Adeghate E, Saeed Z, D'Souza C, Tariq S, Kalász H, Tekes K, Adeghate EA (2018) Effect of nociceptin on insulin release in normal and diabetic rat pancreas. Cell Tissue Res 374:517-529
- Singh RM, Waqar T, Howarth FC, Adeghate E, Bidasee K, Singh J (2018). Hyperglycemia-induced cardiac contractile dysfunction in the diabetic heart. Heart Fail Rev; 23:37-54.
- Al-Taee H, Azimullah S, Meeran MFN, Alaraj Almheiri MK, Al Jasmi RA, Tariq S, Ab Khan M, Adeghate E, Ojha S (2019). β-caryophyllene, a dietary phytocannabinoid, attenuates oxidative stress, inflammation, apoptosis and prevents structural alterations of the myocardium against doxorubicin-induced acute cardiotoxicity in rats: An in vitro and in vivo study. Eur J Pharmacol; 858:172467.
- Karakkat JV, Kaimala S, Sreedharan SP, Jayaprakash P, Adeghate EA, Suraiya Ansari SA, Guccione E, Mensah-Brown EPK, Emerald BS (2019). The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex. Nucleic Acids Res; DOI 10.1093/nar/gkz786. article
- Ansari SA, Emerald BS (2019). The Role of Insulin Resistance and Protein O-GlcNAcylation in Neurodegeneration. Front Neurosci; 13:473.
- Ardah MT, Parween S, Varghese DS, Emerald BS, Ansari SA (2018). Saturated fatty acid alters embryonic cortical neurogenesis through modulation of gene expression in neural stem cells. J Nutr Biochem. 62:230-246.
- Prabakaran AD, Jimsheena Karakkat JV, Ranjit Vijayan R, Chalissery J, Ibrahim MF, Kaimala S, Adeghate EA, Al-Marzouqi AH, Ansari SA, Mensah-Brown EPK, Emerald BS (2018). Identification of early indicators of altered metabolism in normal development using a rodent model system. Disease Models & Mechanisms; 11. pii: dmm031815 .
- Parween S, Varghese DS, Ardah MT, Prabakaran AD, Mensah-Brown EPK, Emerald BS, Ansari SA (2017). Higher O-GlcNAc levels cause defects in progenitor proliferation and premature neuronal differentiation during in vitro human embryonic cortical neurogenesis. Front Cell Neurosci, 11: 415
- Varghese DS, Parveena S, Ardaha MT, Emerald BS and Ansari SA (2017). Effects of aminoglycoside antibiotics on human embryonic stem cell differentiation in vitro. Stem Cells 2017: 2451927
- Tariq S, Nurulain SM, Rashed H, Lotfy M, Emerald BS, Koturan S, Tekes K, Adeghate E (2016). Diabetes-induced changes in the morphology and nociceptinergic innervation of the rat uterus. J Mol Histol; 47:21-33.
- Hatton J, Davis G, Mourad AH, Cherupurakal N, Hill R, Mohsin S (2019). Fabrication of Porous Bone Scaffolds using Alginate and Bioactive Glass. J. Funct. Biomater; 10: 15.
- Adeghate E, Mohsin S, Adi F, et al. (2019). An update of SGLT1 and SGLT2 inhibitors in early-phase diabetes-type 2 clinical trials. Expert Opinion on Investigational Drugs; 28:811- 820.
- Mohsin S, May MYH, AlDarmaki R, Tekes K, Kalász H, Adeghate EA (2019). An update on biological therapies for the treatment of diabetes-induced osteoporosis. Expert Opinion on Biological Therapy; 19:937-948.
- Khoder G, Al-Yassir F, Al Menhali A, Saseedharan P, Sugathan S, Tomasetto C, Karam SM (2019). Probiotics Upregulate Trefoil Factors and Downregulate Pepsinogen in the Mouse Stomach. Int J Mol Sci; 20:1-20.
- Jamal M, Greish Y, Chogle S, Goodis H, Karam SM (2018). Growth and Differentiation of Dental Stem Cells of Apical Papilla on Polycaprolactone Scaffolds. Adv Exp Med Biol; 1077: 31-40.
- Al-Dhaheri W, Hassouna I, Karam SM (2018). Genetic polymorphisms and protein expression of P53 and BRCA1 in preneoplastic and neoplastic rat mammary glands. Oncol Rep; 39: 2193-2200.
- El-Kharrag R, Amin A, Hisaindee S, Greish Y, Karam SM (2017). Development of a therapeutic model of precancerous liver using crocin-coated magnetite nanoparticles. Int J Oncol; 50:212-222.
- Khoder G, Al-Menhali AA, Al-Yassir F, Karam SM (2016). Potential role of probiotics in the management of gastric ulcer. Exp Ther Med; 12:3-17.
- Pulikkot S, Greish YE, Mourad AH, Karam SM (2014). Establishment of a three-dimensional culture system of gastric stem cells supporting mucous cell differentiation using microfibrous polycaprolactone scaffolds. Cell Prolif; 47:553-63.
- Shehab SAS (2014). Fifth lumbar spinal nerve injury causes neurochemical changes in corresponding as well as adjacent spinal segments: A possible mechanism underlying neuropathic pain. Journal of Chemical Neuroanatomy 55: 38–50.
- Shehab S, D'souza C, Ljubisavljevic M, Redgrave P (2014). High-frequency electrical stimulation of the subthalamic nucleus excites target structures in a model using c-fos immunohistochemistry. Neuroscience 270: 212-25.
- Baseer N, Al-Baloushi A, Watanabe M, Shehab SAS, Todd AJ (2014). Selective innervation of NK1 receptor-lacking lamina I spinoparabrachial neurons by presumed non-peptidergic Aδ nociceptors in the rat. Pain 155: 2291-2300.
- Shehab S, Anwer M, Galani D, AbdulKarim Afaf, Al-Nuaimi K, Al-Baloushi A, Tariq S, Nagelkerke N, Ljubisavljevic M (2015). Anatomical Evidence that the Uninjured Adjacent L4 Nerve Plays a Significant Role in the Development of Peripheral Neuropathic Pain after L5 Spinal Nerve Ligation in Rats. Journal of Comparative Neurology 523: 1731-1747.
- Ljubisavljevic MR, Javid A, Oommen J, Parekh K, Shehab S, Adrian TE (2015). The effects of different repetitive transcranial magnetic stimulation (rTMS) protocols on cortical gene expression in ischemic-reperfusion injury in rat. PLoS One October 2, 1-25.
- Hamadi NK, Sheikh A, Madjid N, Lubbad L, Amir N, Shehab SAS, Khelifi-Touhami F, Adem A (2016). Increased pro-inflammatory cytokines, glial activation and oxidative stress in the hippocampus after short-term bilateral adrenalectomy. BMC Neuroscience 17:61. DOI 10.1186/s12868-016-0296-1. article
- Shehab S, D'souza C, Ljubisavljevic M, Redgrave P (2018). Activation of the subthalamic nucleus suppressed by high frequency stimulation: A c-Fos immunohistochemical study. Brain Research 1685 42-50.
- Shehab S, Rehmathulla S, Javed H. (2018). A Single GABA Neuron Receives Contacts from Myelinated Primary Afferents of Two Adjacent Peripheral Nerves. A Possible Role in Neuropathic Pain. Journal of Comparative Neurology 526: 2984–2999.
- Al Aiyan A, Menon P, AlDarwich A, Almuhairi F, Alnuaimi S, Bulshawareb A, Qablan M, Shehab S (2019). Descriptive Analysis of Cerebral Arterial Vascular Architecture in Dromedary Camel (Camelus dromedarius). Front. Neuroanat. 13:67 DOI 10.3389/fnana.2019.00067. article
Books, Chapters, Reviews and Editorials
- Adeghate E, Saadi H, Adem A, Obineche E. Diabetes Mellitus and Its Complications: Molecular Mechanisms, Epidemiology, and Clinical Medicine: Annals of the New York Academy of Sciences: Vol. 1084, 2006. Wiley-Blackwell, ISBN-10: 1573316350.
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Thank you for your interest in the Anatomy Department. We welcome your query and encourage you to contact us using the information below:
United Arab Emirates University,
College of Medicine and Health Sciences
P.O.Box: 17666, Al Ain, UAE
Phone: + 971 3 7137 508
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