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United Arab Emirates University (UAEU) - Best University in Abu Dhabi, UAE
United Arab Emirates University (UAEU) - Best University in Abu Dhabi, UAE
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United Arab Emirates University (UAEU) - Best University in Abu Dhabi, UAE

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Biochemistry and Molecular Biology Department

 

Biochemistry and Molecular Biology Department

Overview

Facilities

Teaching

Publications

Faculty & Staff

General Enquiries

Overview

The Department of Biochemistry and Molecular Biology at the College of Medicine and Health Sciences is a research-focused department. The research interests of its faculty members include investigations of the mechanisms of epigenetic regulation and chromatin remodeling; molecular carcinogenesis and the role of oxidative stress and mitochondrial dysfunction in disease; molecular basis of neurodegenerative disorders; molecular immune-toxicology; molecular basis of diseases induced by retroviruses; and the anticancer and anti-diabetic effects of chemicals and drugs. In addition, research in the Department also focuses on computational studies of mutations in DNA under the effects of external stress factors and evaluating properties of bioisosteres to mark advances in drug design.

In addition to being heavily involved in undergraduate medical teaching, the Department of Biochemistry and Molecular Biology is also offers an MSc program in Medical Sciences. Moreover, faculty members in the Department has been actively contributing towards the training of both Masters and PhD programs at the college. Our graduate programs in the College of Medicine and Health Sciences are multi-disciplinary programs and provide students with a solid foundation in Biochemistry, Molecular and Cellular Biology, and laboratory research training. All faculty members from the Department regularly apply to and receive funding from various grants organizations such as UAEU, Al Jalila Foundation, ADEK, the Sheikh Hamdan Medical Research Awards, and other extramural grants. As a result, the Department has consistently been very productive in publishing over the last many year. In addition, many of these publications are in top journals as the members of the Department always receive recognition from the UAEU for publishing in top ranking journals. Finally, the Department has always contributed and continue to contribute to the training of undergraduate students from the CMHS as well as other colleges (i.e. College of Science internship program) and other universities within the country. 

Facilities

We have state-of-the-art research core facilities in the Department of Biochemistry and Molecular Biology for cell culture, molecular biology, DNA cloning and sequencing, RT-PCR, heterologous protein expression and purification using eukaryotic and prokaryotic systems as well as computational facilities. In addition, the College of Medicine has Imaging, Analytical as well as an animal house for transgenic and knockout animals.

Teaching

Currently the Department of Biochemistry and Molecular Biology runs a total of 10 courses that include 4 courses for undergraduate medical students (Chemistry for Medicine; Biological Chemistry; Molecular Biology; Cellular Communication and Metabolism) as well as 6 graduate level courses for MSc and PhD students (Advanced Molecular Biology; Advanced Cell Biology; Advanced Topics in Biochemistry; Techniques in Biochemistry; and Special Topics in Biochemistry).

The Biochemistry and Molecular Biology (BMB) MSc program and the PhD program in Biomedical Sciences at the College of Medicine and Health Sciences provides students with a foundation in Biochemistry, Molecular, and Cellular Biology as well as intensive laboratory and computational research training ranging from basic science projects to more specialized research projects. The faculty members in the Department of Biochemistry and Molecular Biology have collaborations nationally and internationally with well-known universities and active researchers. The goal of this program is the development of graduates who will pursue careers as independent investigators with an appreciation for both basic and clinical aspects of biomedical research. 

Publications

  • Hamouda, M., Mustafa, F., Maraqa, M., Rizvi, T., Aly Hassan, A. (2021). Wastewater surveillance for SARS-CoV-2: Lessons learnt from recent studies to define future applications. Science of the Total Environment, 759, 143493.
  • Jalal D., Chalissery J., Iqbal M. and Hassan A.H. (2021). The ATPase Irc20 facilitates Rad51 nucleofilament formation during homologous recombination in yeast Saccharomyces cerevisiae. DNA Repair, vol. 97, 103019.
  • Al-Natour Z., Chalissery J. and Hassan A. H. (2020). Importance of Fun30 chromatin remodeler in dealing torsional stress and camptothecin induced DNA damage. Yeast, https://doi.org/10.1002/yea.3534.
  • Jalal D., Chalissery J., Iqbal M. and Hassan A.H. (2020). Irc20 regulates the yeast endogenous 2-µm plasmid levels by controlling Flp1. Frontiers in Molecular Biosciences, 7, 221.
  • Alnahdi A, John A, Raza H (2020). Mitigation of glucolipotoxicity-induced apoptosis, mitochondrial dysfunction and metabolic stress by N-acetyl cysteine in pancreatic β-Cells. Biomolecules, 10(2), 239.
  • Sheikh MA, Starling Emerald B, Ansari SA. (2020). Stem cell fate determination through protein O-GlcNAcylation. J Biol Chem. Nov 5:jbc.REV120.014915.
  • Ahmed SAH, Ansari SA, Mensah-Brown EPK, Emerald BS. (2020). The role of DNA methylation in the pathogenesis of type 2 diabetes mellitus. Clin Epigenetics;12(1):104. Published 2020 Jul 11.
  • Gheorghiu, A., Coveney, P.V., Arabi, A.A. (2020). The influence of base pair tautomerism on single point mutations in aqueous DNA: Base pair mutations in aqueous DNA. Interface Focus, 10(6), 20190120.
  • Al Rashdi, M.R., El Tokhi, M., Alaabed, S., El Mowafi, W., Arabi, A.A. (2020). Rare Earth Elements Around the Barakah Nuclear Power Plant, UAE. Natural Resources Research, 29(6), pp. 4149–4160.
  • Arabi, A.A. (2020). Atomic and molecular properties of nonclassical bioisosteric replacements of the carboxylic acid group. Future Medicinal Chemistry, 12(12), pp. 1111–1120.
  • Arabi, A.A. (2020). Binding energies of van der Waals complexes at non-equilibrium geometries. Chemical Physics, 529, 110545.
  • Afrin S., Haneefa S.M., Fernandez-Cabezudo M.J., Giampieri F., al-Ramadi B.K., Battino M. (2020). Therapeutic and preventive properties of honey and its bioactive compounds in cancer: An evidence-based review. Nutrition Research Reviews. 33(1):50-76.
  • Kappes L., Amer R.L., Sommerlatte S., Bashir G., Plattfaut C., Gieseler F., Gemoll T., Busch H., Altahrawi A., Al-Sbiei A., Haneefa S.M., Arafat K., Schimke L.F., El Khawanky N., Schulze-Forster K., Heideck H., Heidecke H., Kerstein-Staehle A., Marschner G., Pitanna S., Ochs H.D., Mueller A., Attoub S., Fernandez-Cabezudo M.J., Riemekasten G., al-Ramadi B.K., Cabral-Marques O. (2020). Ambrisentan, an endothelin receptor type A-selective antagonist, inhibits cancer cell migration, invasion and metastasis. Scientific Reports. 10 (1):15931.
  • Stip, E., Rizvi, T.A., Mustafa, F., ...Al Mugaddam, F., Khan, G. (2020). The Large Action of Chlorpromazine: Translational and Transdisciplinary Considerations in the Face of COVID-19. Frontiers in Pharmacology, 2020, 11, 577678.
  • Ali, L.M., Pitchai, F.N.N., Vivet-Boudou, V., ...Marquet, R., Rizvi, T.A. (2020). Role of Purine-Rich Regions in Mason-Pfizer Monkey Virus (MPMV) Genomic RNA Packaging and Propagation. Frontiers in Microbiology, 2020, 11, 595410.
  • Al Ahmad, M., Raji, S., Mustafa, F., Rizvi, T.A., Al-Zuhair, S. (2020). Simultaneous and rapid quantification of microalga biomolecule content using electrochemical impedance spectroscopy. Biotechnology Progress, 2020, 36(6), e3037.
  • Uddin, M., Mustafa, F., Rizvi, T.A., Loney, T., Al Suwaidi, H., Al-Marzouqi, A.H.H., Eldin, A.K., Alsabeeha, N., Adrian, T.E., Stefanini, C., Nowotny, N., Alsheikh-Ali, A., Senok, A.C. (2020). SARS-CoV-2/COVID-19: Viral genomics, epidemiology, vaccines, and therapeutic interventions. Viruses, 2020, 12(5), v12050526.
  • Panicker, N.G., Balhamar, S.O.M.S., Akhlaq, S., ...Hussain, J., Mustafa, F. (2020). Organic extracts from Cleome droserifolia exhibit effective caspase-dependent anticancer activity. BMC complementary medicine and therapies, 20(1), pp. 74.
  • Nasir, N., Raji, S., Mustafa, F., ...Hilal-Alnaqbi, A., Al Ahmad, M. (2020). Electrical detection of blood cells in urine. Heliyon, 6(1), e03102.
  • Lin, J., Chen, K., Chen, W., ...Li, Y., Yang, Y. (2020). Paradoxical Mitophagy Regulation by PINK1 and TUFm. Molecular Cell, 80(4), pp. 607–620.e12.
  • Ardah, M.T., Bharathan, G., Kitada, T., Haque, M.E. (2020). Ellagic acid prevents dopamine neuron degeneration from oxidative stress and neuroinflammation in MPTP model of Parkinson’s disease. Biomolecules, 10(11), pp. 1–17, 1519.
  • Sun, L., Zhang, J., Chen, W., ...Huang, K., Yang, Y. (2020). Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration. Aging Cell, 19(9), e13210.
  • Ahmed Al Marzouqi, Mohamad Alameddine, Amer Sharif, Alawi Alsheikh-Ali (2019). Research productivity in the United Arab Emirates: A 20-Year bibliometric analysis, Heliyon. Volume 5, Issue 12, e02819.
  • Ardah, M.T., Merghani, M.M., Haque, M.E. (2019). Thymoquinone prevents neurodegeneration against MPTP in vivo and modulates α-synuclein aggregation in vitro. Neurochemistry International, 128, pp. 115–126
  • Al Nahdi MT Arwa, John A, Raza H (2019). Streptozotocin-induced molecular and metabolic targets in pancreatic beta cell toxicity.Hamdan Med J;12:65-71.
  • Alnahdi A, John A, Raza H (2019). Augmentation of Glucotoxicity, Oxidative Stress, Apoptosis and Mitochondrial Dysfunction in HepG2 Cells by Palmitic Acid. Nutrients. Aug 22;11(9).
  • Alnahdi A, John A, Raza H (2019). N-acetylcysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells. PLoS ONE 14(12):e0226696.
  • Karakkat JV, Kaimala S, Sreedharan SP, Jayaprakash P, Adeghate EA, Ansari SA, Guccione E, Mensah-Brown EPK, Starling Emerald B. (2019). The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex. Nucleic Acids Res. Nov 4;47(19):10086-10103.
  • Ansari SA, Emerald BS. (2019). The Role of Insulin Resistance and Protein O-GlcNAcylation in Neurodegeneration. Front Neurosci. 9;13:473.
  • Javed H, Azimullah S, Meeran MN, Ansari SA, Ojha S. (2019). Neuroprotective Effects of Thymol, a Dietary Monoterpene Against Dopaminergic Neurodegeneration in Rotenone-Induced Rat Model of Parkinson’s Disease. Int. J. Mol. Sci., 20, 1538.
  • Varghese DS, Alawathugoda TT, Ansari SA (2019). Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches. Stem Cells International, vol. 2019, Article ID 5968236, 18 pages, 2019.
  • Ardah M.T., Merghani M.M., Haque M.E. (2019). Thymoquinone prevents neurodegeneration against MPTP in vivo and modulates α-synuclein aggregation in vitro. Neurochemistry International 128 (), 115-126
  • Kalloush R.M., Vivet-Boudou V., Ali L.M., Pillai V.N., Mustafa F., Marquet R., Rizvi T.A. (2019). Stabilizing role of structural elements within the 5´ Untranslated Region (UTR) and gag sequences in Mason-Pfizer monkey virus (MPMV) genomic RNA packaging. RNA Biology 16 (5), 612-625
  • Varghese D.S., Alawathugoda T.T., Ansari S.A. (2019). Fine tuning of hepatocyte differentiation from human embryonic stem cells: Growth factor vs. Small molecule-based approaches. Stem Cells International 2019 (), 5968236
  • Fernández-Cabezudo M.J., George J.A., Bashir G., Mohamed Y.A., Al-Mansori A., Qureshi M.M., Lorke D.E., Petroianu G., Al-Ramadi B.K. (2019). Involvement of acetylcholine receptors in cholinergic pathway-mediated protection against autoimmune diabetes. Frontiers in Immunology 10 (MAY), 1038
  • Javed H., Azimullah S., Meeran M.F.N., Ansari S.A., Ojha S. (2019). Neuroprotective effects of thymol, a dietary monoterpene against dopaminergic neurodegeneration in rotenone-induced rat model of parkinson's disease. International Journal of Molecular Sciences 20 (7), 1538
  • Aryappalli P., Shabbiri K., Masad R.J., Al-Marri R.H., Haneefa S.M., Mohamed Y.A., Arafat K., Attoub S., Cabral-Marques O., Ramadi K.B., Fernandez-Cabezudo M.J., Al-Ramadi B.K. (2019). Inhibition of tyrosine-phosphorylated STAT3 in human breast and lung cancer cells by manuka honey is mediated by selective antagonism of the IL-6 receptor. International Journal of Molecular Sciences 20 (18), 4340
  • Panicker N.G., Balhamar S.O.M.S., Akhlaq S., Qureshi M.M., Rizvi T.S., Al-Harrasi A., Hussain J., Mustafa F. (2019). Identification and Characterization of the Caspase-Mediated Apoptotic Activity of Teucrium mascatense and an Isolated Compound in Human Cancer Cells. Molecules 24 (5), 977
  • Alnahdi A., John A., Raza H. (2019). Augmentation of glucotoxicity, oxidative stress, apoptosis and mitochondrial dysfunction in hepg2 cells by palmitic acid. Nutrients 11 (9), 1979
  • Krishnan A., Pillai V.N., Chameettachal A., Ali L.M., Pitchai F.N.N., Tariq S., Mustafa F., Marquet R., Rizvi T.A. (2019). Purification and functional characterization of a biologically active full-length feline immunodeficiency virus (FIV) pr50gag. Viruses 11 (8), 689
  • Ansari S.A., Emerald B.S. (2019). The role of insulin resistance and protein O-GlcNAcylation in Neurodegeneration. Frontiers in Neuroscience 13 (MAY), 473
  • Mozumder M.S., Mourad A.-H.I., Mairpady A., Pervez H., Haque M.E. (2018). Effect of TiO 2 Nanofiller Concentration on the Mechanical, Thermal and Biological Properties of HDPE/TiO 2 Nanocomposites. Journal of Materials Engineering and Performance 27 (5), 2166-2181
  • Cabral-Marques O., França T.T., Al-Sbiei A., Schimke L.F., Khan T.A., Feriotti C., da Costa T.A., Junior O.R., Weber C.W., Ferreira J.F., Tavares F.S., Valente C., Di Gesu R.S.W., Iqbal A., Riemekasten G., Amarante-Mendes G.P., Marzagão Barbuto J.A., Cost (2018). CD40 ligand deficiency causes functional defects of peripheral neutrophils that are improved by exogenous IFN-γ. Journal of Allergy and Clinical Immunology 142 (5), 1571-1588000000000
  • Akhlaq S., Panicker N.G., Philip P.S., Ali L.M., Dudley J.P., Rizvi T.A., Mustafa F. (2018). A cis-Acting Element Downstream of the Mouse Mammary Tumor Virus Major Splice Donor Critical for RNA Elongation and Stability. Journal of Molecular Biology 430 (21), 4307-4324
  • Ardah M.T., Parween S., Varghese D.S., Emerald B.S., Ansari S.A. (2018). Saturated fatty acid alters embryonic cortical neurogenesis through modulation of gene expression in neural stem cells. Journal of Nutritional Biochemistry 62 (), 230-246
  • Kincaid R.P., Panicker N.G., Lozano M.M., Sullivan C.S., Dudley J.P., Mustafa F. (2018). MMTV does not encode viral microRNAs but alters the levels of cancer-associated host microRNAs. Virology 513 (), 180-187
  • Cabral-Marques O., Marques A., Giil L.M., De Vito R., Rademacher J., Günther J., Lange T., Humrich J.Y., Klapa S., Schinke S., Schimke L.F., Marschner G., Pitann S., Adler S., Dechend R., Müller D.N., Braicu I., Sehouli J., Schulze-Forster K., Trippel T., (2018). GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis. Nature Communications 9 (1), 5224
  • Pitchai F.N.N., Ali L., Pillai V.N., Chameettachal A., Ashraf S.S., Mustafa F., Marquet R., Rizvi T.A. (2018). Expression, purification, and characterization of biologically active full-length Mason-Pfizer monkey virus (MPMV) Pr78Gag. Scientific Reports 8 (1), 11793
  • Mustafa F., Vivet-Boudou V., Jabeen A., Ali L.M., Kalloush R.M., Marquet R., Rizvi T.A. (2018). The bifurcated stem loop 4 (SL4) is crucial for efficient packaging of mouse mammary tumor virus (MMTV) genomic RNA. RNA Biology 15 (8), 1047-1059
  • Ghosh J., Chowdhury A.R., Srinivasan S., Chattopadhyay M., Bose M., Bhattacharya S., Raza H., Fuchs S.Y., Rustgi A.K., Gonzalez F.J., Avadhani N.G. (2018). Cigarette Smoke Toxins-Induced Mitochondrial Dysfunction and Pancreatitis Involves Aryl Hydrocarbon Receptor Mediated Cyp1 Gene Expression: Protective Effects of Resveratrol. Toxicological sciences : an official journal of the Society of Toxicology 166 (2), 428-440
  • Al Ahmad M., Al Natour Z., Attoub S., Hassan A.H. (2018). Monitoring of the Budding Yeast Cell Cycle Using Electrical Parameters. IEEE Access 6 (), 19231-19237
  • Al Ahmad M., Al Natour Z., Mustafa F., Rizvi T.A. (2018). Electrical Characterization of Normal and Cancer Cells. IEEE Access 6 (), 25979-25986
  • Al Ahmad M., Akhlaq S., Rizvi T.A., Mustafa F. (2018). Detection of Mouse Mammary Tumor Virus (MMTV) Particles in an Immortalized T Cell Line Based on Electrical Parameters. IEEE Access 6 (), 63597-63605
  • Arafat K., Al Kubaisy E., Sulaiman S., Karam S.M., Al Natour Z., Hassan A.H., Attoub S. (2018). SMARCAD1 in Breast Cancer Progression. Cellular Physiology and Biochemistry 50 (2), 501-511
  • Al-Nahdi A.M.T., John A., Raza H. (2018). Cytoprotective effects of N-acetylcysteine on streptozotocin-induced oxidative stress and apoptosis in RIN-5F pancreatic β-cells. Cellular Physiology and Biochemistry 51 (1), 201-216
  • Al-Barazie R.M., Bashir G.H., Qureshi M.M., Mohamed Y.A., Al-Sbiei A., Tariq S., Lammers W.J., al-Ramadi B.K., Fernandez-Cabezudo M.J. (2018). Cholinergic activation enhances resistance to oral Salmonella infection by modulating innate immune defense mechanisms at the intestinal barrier. Frontiers in Immunology 9 (MAR), 551
  • Issac J.M., Mohamed Y.A., Bashir G.H., Al-Sbiei A., Conca W., Khan T.A., Iqbal A., Riemekasten G., Bieber K., Ludwig R.J., Cabral-Marques O., Fernandez-Cabezudo M.J., Al-Ramadi B.K. (2018). Induction of hypergammaglobulinemia and autoantibodies by Salmonella infection in MyD88-deficient mice. Frontiers in Immunology 9 (JUN), 1384
  • Khair S.B.A., Dhanushkodi N.R., Ardah M.T., Chen W., Yang Y., Haque M.E. (2018). Silencing of glucocerebrosidase gene in Drosophila enhances the aggregation of Parkinson's disease associated α-synuclein mutant A53T and affects locomotor activity. Frontiers in Neuroscience 12 (FEB), 81
  • Kaimala S., Al-Sbiei A., Cabral-Marques O., Fernandez-Cabezudo M.J., Al-Ramadi B.K. (2018). Attenuated bacteria as immunotherapeutic tools for cancer treatment. Frontiers in Oncology 8 (MAY), 136
  • Chameettachal A., Pillai V.N., Ali L.M., Pitchai F.N.N., Ardah M.T., Mustafa F., Marquet R., Rizvi T.A. (2018). Biochemical and functional characterization of mouse mammary tumor virus full-length Pr77Gag expressed in prokaryotic and eukaryotic cells. Viruses 10 (6), 334
  • Ardah M.T., Parween S., Varghese D.S., Emerald B.S., Ansari S.A. (2018). Saturated fatty acid regulated lncRNA dataset during in vitro human embryonic neurogenesis. Data in Brief 21 (), 1061-1065
  • Ranjan A., Ansari S.A. (2018). Therapeutic potential of Mediator complex subunits in metabolic diseases. Biochimie 144 (), 41-49
  • Prabakaran A.D., Karakkat J.V., Vijayan R., Chalissery J., Ibrahim M.F., Kaimala S., Adeghate E.A., Al-Marzouqi A.H., Ansari S.A., Mensah-Brown E., Emerald B.S. (2018). Identification of early indicators of altered metabolism in normal development using a rodent model system. DMM Disease Models and Mechanisms 11 (3), 31815
  • Al Ahmad M., Al-Zuhair S., Hilal-Alnaqbi A., Mustafa F. (2017). Visualization and quantification of oil in single microalgal cells. Journal of Applied Phycology 29 (3), 1195-1202
  • Qadri S., Haik Y., Mensah-Brown E., Bashir G., Fernandez-Cabezudo M.J., al-Ramadi B.K. (2017). Metallic nanoparticles to eradicate bacterial bone infection. Nanomedicine: Nanotechnology, Biology, and Medicine 13 (7), 2241-2250
  • Marcogliese P.C., Abuaish S., Kabbach G., Abdel-Messih E., Seang S., Li G., Slack R.S., Haque M.E., Venderova K., Park D.S. (2017). LRRK2(I2020T) functional genetic interactors that modify eye degeneration and dopaminergic cell loss in Drosophila. Human Molecular Genetics 26 (7), 1247-1257
  • Varghese D.S., Parween S., Ardah M.T., Emerald B.S., Ansari S.A. (2017). Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation in Vitro. Stem Cells International 2017 (), 2451927
  • Anandasadagopan S.K., Singh N.M., Raza H., Bansal S., Selvaraj V., Singh S., Chowdhury A.R., Leu N.A., Avadhani N.G. (2017). β-Naphthoflavone-Induced Mitochondrial Respiratory Damage in Cyp1 Knockout Mouse and in Cell Culture Systems: Attenuation by Resveratrol Treatment. Oxidative Medicine and Cellular Longevity 2017 (), 5213186
  • Nahdi A.M.T.A., John A., Raza H. (2017). Elucidation of Molecular Mechanisms of Streptozotocin-Induced Oxidative Stress, Apoptosis, and Mitochondrial Dysfunction in Rin-5F Pancreatic β -Cells. Oxidative Medicine and Cellular Longevity 2017 (), 7054272
  • Parween S., Varghese D.S., Ardah M.T., Prabakaran A.D., Mensah-Brown E., Emerald B.S., Ansari S.A. (2017). Higher O-GlcNAc levels are associated with defects in progenitor proliferation and premature neuronal differentiation during in-vitro human embryonic cortical neurogenesis. Frontiers in Cellular Neuroscience 11 (), 415
  • Aryappalli P., Al-Qubaisi S.S., Attoub S., George J.A., Arafat K., Ramadi K.B., Mohamed Y.A., Al-Dhaheri M.M., Al-Sbiei A., Fernandez-Cabezudo M.J., Al-Ramadi B.K. (2017). The IL-6/STAT3 signaling pathway is an early target of manuka honey-induced suppression of human breast cancer cells. Frontiers in Oncology 7 (AUG), 167
  • Chalissery J., Jalal D., Al-Natour Z., Hassan A.H. (2017). Repair of Oxidative DNA Damage in Saccharomyces cerevisiae. DNA Repair 51 (), 2-13
  • Jalal D., Chalissery J., Hassan A.H. (2017). Genome maintenance in Saccharomyces cerevisiae: The role of SUMO and SUMO-targeted ubiquitin ligases. Nucleic Acids Research 45 (5), 2242-2261
  • Majbour N.K., Vaikath N.N., Eusebi P., Chiasserini D., Ardah M., Varghese S., Haque M.E., Tokuda T., Auinger P., Calabresi P., Parnetti L., El-Agnaf O.M.A. (2016). Longitudinal changes in CSF alpha-synuclein species reflect Parkinson's disease progression. Movement Disorders 31 (10), 1535-1542
  • Ojha S., Javed H., Azimullah S., Haque M.E. (2016). β-Caryophyllene, a phytocannabinoid attenuates oxidative stress, neuroinflammation, glial activation, and salvages dopaminergic neurons in a rat model of Parkinson disease. Molecular and Cellular Biochemistry 418 (43497), 59-70
  • Ojha S., Javed H., Azimullah S., Abul Khair S.B., Haque M.E. (2016). Glycyrrhizic acid Attenuates Neuroinflammation and Oxidative Stress in Rotenone Model of Parkinson's Disease. Neurotoxicity Research 29 (2), 275-287
  • Javed H., Menon S.A., Al-Mansoori K.M., Al-Wandi A., Majbour N.K., Ardah M.T., Varghese S., Vaikath N.N., Haque M.E., Azzouz M., El-Agnaf O.M.A. (2016). Development of nonviral vectors targeting the brain as a therapeutic approach for Parkinson's disease and other brain disorders. Molecular Therapy 24 (4), 746-758
  • Fernández-Cabezudo M.J., Faour I., Jones K., Champagne D.P., Jaloudi M., Mohamed Y.A., Bashir G., AlMarzooqui S., Al Bawardi A., Hashim M.J., Roberts T.S., El-Salhat H., El-Taji H., Kassis A., O’Sullivan D.E., Christensen B.C., DeGregori J., al-Ramadi B.K., Rincon M. (2016) Deficiency of mitochondrial modulator MCJ/DNAJC15 promotes chemoresistance in breast cancer. JCI Insight. 1(7): e86873
  • Ahmad M.A., Milhem R.M., Panicker N.G., Rizvi T.A., Mustafa F. (2016). Electrical characterization of DNA supported on nitrocellulose membranes. Scientific Reports 6 (), 29089
  • Ahmad M.A., Panicker N.G., Rizvi T.A., Mustafa F. (2016). Electrical detection and quantification of single and mixed DNA nucleotides in suspension. Scientific Reports 6 (), 34016
  • Al Kubaisy E., Arafat K., De Wever O., Hassan A.H., Attoub S. (2016). SMARCAD1 knockdown uncovers its role in breast cancer cell migration, invasion, and metastasis. Expert Opinion on Therapeutic Targets 20 (9), 1035-1043
  • Basanta-Sanchez M., Temple S., Ansari S.A., D'Amico A., Agris P.F. (2016). Attomole quantification and global profile of RNA modifications: Epitranscriptome of human neural stem cells. Nucleic Acids Research 44 (3), e26
  • Javed H., Azimullah S., Abul Khair S.B., Ojha S., Haque M.E. (2016). Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone. BMC Neuroscience 17 (1), 58
  • Kalloush R.M., Vivet-Boudou V., Ali L.M., Mustafa F., Marquet R., Rizvi T.A. (2016). Packaging of mason-pfizer monkey virus (MPMV) genomic RNA depends upon conserved long-range interactions (LRIs) between U5 and gag sequences. RNA 22 (6), 905-919
  • Ferdous Z., Qureshi M.A., Jayaprakash P., Parekh K., John A., Oz M., Raza H., Dobrzynski H., Adrian T.E., Howarth F.C. (2016). Different profile of mRNA expression in sinoatrial node from streptozotocin-induced diabetic rat. PLoS ONE 11 (4), e0153934
  • Raza H., John A., Shafarin J. (2016). Potentiation of LPS-induced apoptotic cell death in human hepatoma HepG2 cells by aspirin via ROS and mitochondrial dysfunction: Protection by N-acetyl cysteine. PLoS ONE 11 (7), e0159750
  • Raza H., John A., Shafarin J., Howarth F.C. (2016). Exercise-induced alterations in pancreatic oxidative stress and mitochondrial function in type 2 diabetic Goto-Kakizaki rats. Physiological Reports 4 (8), e12751
  • Ramadi K.B., Mohamed Y.A., Al-Sbiei A., Almarzooqi S., Bashir G., Al Dhanhani A., Sarawathiamma D., Qadri S., Yasin J., Nemmar A., Fernandez-Cabezudo M.J., Haik Y., Al-Ramadi B.K. (2016). Acute systemic exposure to silver-based nanoparticles induces hepatotoxicity and NLRP3-dependent inflammation. Nanotoxicology 10 (8), 1061-1074
  • George J.A., Bashir G., Qureshi M.M., Mohamed Y.A., Azzi J., Al-Ramadi B.K., Fernández-Cabezudo M.J. (2016). Cholinergic stimulation prevents the development of autoimmune diabetes: Evidence for the modulation of Th17 effector cells via an IFNγ-dependent mechanism. Frontiers in Immunology 7 (OCT), 419
  • Javed H., Azimullah S., Haque M.E., Ojha S.K. (2016). Cannabinoid type 2 (CB2) receptors activation protects against oxidative stress and neuroinflammation associated dopaminergic neurodegeneration in rotenone model of parkinson's disease. Frontiers in Neuroscience 10 (AUG), 321
  • Javed H., Menon S.A., Al-Mansoori K.M., Al-Wandi A., Majbour N.K., Ardah M.T., Varghese S., Vaikath N.N., Haque M.E., Azzouz M., El-Agnaf O.M.A. (2016). Erratum: Development of nonviral vectors targeting the brain as a therapeutic approach for Parkinson's disease and other brain disorders (Molecular Therapy (2016) 24 (746758)) DOI:10.1038/mt.2015.232). Molecular Therapy 24 (4), 843-
  • Ansari S.A., Paul E., Sommer S., Lieleg C., He Q., Daly A.Z., Rode K.A., Barber W.T., Ellis L.C., LaPorta E., Orzechowski A.M., Taylor E., Reeb T., Wong J., Korber P., Morse R.H. (2016). Erratum: Mediator, TATA-binding protein, and RNA polymerase II contribute to low histone occupancy at active gene promoters in yeast (Journal of Biological Chemistry (2014) 289). Journal of Biological Chemistry 291 (19), 9938-
  • Ali L.M., Rizvi T.A., Mustafa F. (2016). Cross- and co-packaging of retroviral RNAs and their consequences. Viruses 8 (10), 276
  • Ahmad M.A., Mustafa F., Ali L.M., Karakkat J.V., Rizvi T.A. (2015). Label-free capacitance-based identification of viruses. Scientific Reports 5 (), 9809
  • Raza H., John A., Howarth F.C. (2015). Increased oxidative stress and mitochondrial dysfunction in zucker diabetic rat liver and brain. Cellular Physiology and Biochemistry 35 (3), 1241-1251
  • Amiri L., John A., Shafarin J., Adeghate E., Jayaprakash P., Yasin J., Howarth F.C., Raza H. (2015). Enhanced Glucose Tolerance and Pancreatic Beta Cell Function by Low Dose Aspirin in Hyperglycemic Insulin-Resistant Type 2 Diabetic Goto-Kakizaki (GK) Rats. Cellular Physiology and Biochemistry 36 (5), 1939-1950
  • Raza H., John A. (2015). Differential cytotoxicity of acetaminophen in mouse macrophage J774.2 and human hepatoma HepG2 cells: Protection by diallyl sulfide. PLoS ONE 10 (12), e0145965
  • Ojha S., Javed H., Azimullah S., Khair S.B.A., Haque M.E. (2015). Neuroprotective potential of ferulic acid in the rotenone model of Parkinson's disease. Drug Design, Development and Therapy 9 (), 5499-5510

  • Hilal-Alnaqbi A., Al Ahmad M., Rizvi T.A., Mustafa F. (2017). Investigation of DNA sequences utilizing frequency-selective nanopore structures. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 3-11
  • Ghaffar A., Niazi M.A., Mustafa F. (2012). A critical examination of complex network file formats for bioinformatics data sources. Proceedings - 10th International Conference on Frontiers of Information Technology, FIT 2012, 354-359
  • Siddiqa A., Niazi M., Mustafa F., Bokhari H., Hussain A., Akram N., Shaheen S., Ahmed F., Iqbal S. (2009). A new hybrid agent-based modeling & simulation decision support system for breast cancer data analysis. 2009 International Conference on Information and Communication Technologies, ICICT 2009, 134-139
  • Siddig A., Mohamed A.O., Kamal H., Awad S., Hassan A.H., Zilahi E., Al-Haj M., Bernsen R., Adem A. (2008). HER-2/neu Ile655Val polymorphism and the risk of breast cancer: A case-control study. Annals of the New York Academy of Sciences 1138, 84-94
  • Siddig A., Mohamed A.O., Awad S., Hassan A.H., Zilahi E., Al-Haj M., Bernsen R., Adem A. (2008). Estrogen receptor α gene polymorphism and breast cancer. Annals of the New York Academy of Sciences 1138, 95-107
  • Al-Ramadi B.K., Fernandez-Cabezudo M.J., El-Hasasna H., Al-Salam S., Attoub S., Xu D., Chouaib S. (2008). Attenuated bacteria as effectors in cancer immunotherapy. Annals of the New York Academy of Sciences 1138, 351-357
  • Raza H., John A. (2008). In vitro effects of tea polyphenols on redox metabolism, oxidative stress, and apoptosis in PC12 cells. Annals of the New York Academy of Sciences 1138, 358-365
  • Al-Ramadi B.K., Adeghate E., Mustafa N., Ponery A.S., Fernandez-Cabezudo M.J. (2002). Cytokine expression by attenuated intracellular bacteria regulates the immune response to infection: The Salmonella model. Molecular Immunology 38 (41609), 931-940
  • Yang K., Mustafa F., Valsamakis A., Santoro J.C., Griffin D.E., Robinson H.L. (1997). Early studies on DNA-based immunizations for measles virus. Vaccine 15 (8), 888-891

  • Raza H., Guengerich F.P., Avadhani N.G. (2018). Mitochondria-Targeted Cytochromes P450 Modulate Adverse Drug Metabolism and Xenobiotic-Induced Toxicity. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants 43497, 35-46
  • Dhanushkodi N.R., Emdadul Haque M. (2018). Molecular mechanisms of neurodegeneration: Insights from the studies of genetic model of parkinson's disease. Pathology, Prevention and Therapeutics of Neurodegenerative Disease, 15-29

Faculty

Note: If calling from outside the UAEU organization, dial (+971 3 713) before the extension.

Name Position Email Extension
Prof.  Ahmed H. Al- Marzouqi Professor and Chair ahmedh@uaeu.ac.ae 7478
Prof. Farah Mustafa Professor mustafa@uaeu.ac.ae 7509
Prof. Haider Raza Professor h.raza@uaeu.ac.ae 7506
Prof. Maria J. Fernandez-Cabezudo Professor mariac@uaeu.ac.ae 7503
Dr. Alya Arabi Associate Professor alya.arabi@uaeu.ac.ae 7630
Dr. Md Emdadul Haque Associate Professor ehaque@uaeu.ac.ae 7517
Dr. Suraiya A. Ansari Associate Professor sansari@uaeu.ac.ae 7484

Staff

Note: If calling from outside the UAEU organization, dial (+971 3 713) before the extension.

Name Position Email Extension
Mr. MHD Achraf Al Sbiei Medical Research Specialist I achraf.alsbiei@uaeu.ac.ae 7751
Dr. Anju Pushkaran Medical Research Specialist I anju.p@uaeu.ac.ae 7631
Ms. Annie S. Sunny Medical Research Specialist I anniej@uaeu.ac.ae 7632
Dr. Jisha Chalissery Medical Research Specialist I jishachalissery@uaeu.ac.ae 7636
Dr. Muhammad Abid Sheikh Medical Research Specialist I m.abid@uaeu.ac.ae 7621
Dr. Mustafa T. Mohammad Ardah Medical Research Specialist I mustafa_ardah@uaeu.ac.ae 7314
Dr. Waqar Ahmad Medical Research Specialist I waqar.ahmad@uaeu.ac.ae 7641

General Enquiries

Thank you for your interest in the Biochemistry and Molecular Biology Department. We welcome your query and encourage you to contact us using the information below:

United Arab Emirates University,
College of Medicine and Health Sciences
P.O.Box: 17666, Al Ain, UAE

Phone : + 971 3 7137 502 

 

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