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United Arab Emirates University (UAEU) - Best University in Abu Dhabi, UAE
United Arab Emirates University (UAEU) - Best University in Abu Dhabi, UAE
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United Arab Emirates University (UAEU) - Best University in Abu Dhabi, UAE

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Department of Pharmacology and Therapeutics

Department of Pharmacology and Therapeutics

Overview

Teaching

Academic Programs

Publications

Faculty & Staff

General Enquiries

Overview

The Department of Pharmacology and Therapeutics research interests include Diabetes and Degenerative Diseases, Neuroscience, Behavioral Neuropharmacology, Clinical Pharmacy, Clinical Toxicology, Gastroenterology and Cancer. The research is done with state-of-the-art equipment in purpose- built laboratories with good technical and other support.

The Department of Pharmacology and Therapeutics is a central participant in medical education leading to the MD degree. In addition, we contribute to teaching and practical research training in Pharmacology and Toxicology, Master and PhD programs in Biomedical Sciences, and the Professional Program leading to the Doctor of Pharmacy..

Teaching

Fundamental principles of pharmacology and autonomic pharmacology are taught in the second year of the curriculum; groups of drugs are covered during the third and fourth years in conjunction with structure-function relationships and the pathophysiology of disease according to organ systems. The department also participates in teaching clinical pharmacology and therapeutics during the clinical clerkships.

Master of Medical Science track Pharmacology and Toxicology: The Department offers this multidisciplinary program designed to prepare highly qualified individuals to be successful scientists in academic and industrial biomedical research.

PharmD Program: The Postgraduate Doctor of Pharmacy pathway is a professional program offered to licensed pharmacists with an accredited baccalaureate degree in pharmacy who wish to earn a higher degree relevant to clinical practice. The program is designed and developed to satisfy the needs of practicing pharmacists at health care centers within the country. The duration of the program is 2 years full time.

PhD in Biomedical Sciences: we offer the Current Advances in Pharmacological Sciences course and we are also involved in other PhD courses like Advanced Cancer Biology course..

 

Academic Programs

Publications

  1. Nagoor Meeran MF, Sharma C, Goyal SN, Kumar S, Ojha S. CB2 receptor-selective agonists as candidates for targeting infection, inflammation, and immunity in SARS-CoV-2 infections. Drug Dev Res. 2020 Nov 15. doi: 10.1002/ddr.21752.
  2. Patil AS, Mahajan UB, Agrawal YO, Patil KR, Patil CR, Ojha S, Sharma C, Goyal SN. Plant-derived natural therapeutics targeting cannabinoid receptors in metabolic syndrome and its complications: A review. Biomed Pharmacother. 2020 Oct 22;132:110889. doi: 10.1016/j.biopha.2020.110889.
  3. Jayaraj RL, Beiram R, Azimullah S, Mf NM, Ojha S, Adem A, Jalal FY. Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways. Int J Mol Sci. 2020 Oct 16;21(20):7670. doi: 10.3390/ijms21207670.
  4. Javed H, Meeran MFN, Azimullah S, Bader Eddin L, Dwivedi VD, Jha NK, Ojha S. α-Bisabolol, a Dietary Bioactive Phytochemical Attenuates Dopaminergic Neurodegeneration through Modulation of Oxidative Stress, Neuroinflammation and Apoptosis in Rotenone-Induced Rat Model of Parkinson's disease. Biomolecules. 2020 Oct 8;10(10):1421. doi: 10.3390/biom10101421.
  5. El Nebrisi E, Javed H, Ojha S, Oz M, Shehab S. Neuroprotective Effect of Curcumin on the Nigrostriatal Pathway in a 6-Hydroxydopmine-Induced Rat Model of Parkinson's Disease is Mediated by α7-Nicotinic Receptors. Int J Mol Sci. 2020 Oct 3;21(19):7329. doi: 10.3390/ijms21197329.
  6. Hashiesh HM, Meeran MFN, Sharma C, Sadek B, Kaabi JA, Ojha S. Therapeutic Potential of β-Caryophyllene: A Dietary Cannabinoid in Diabetes and Associated Complications. Nutrients. 2020 Sep 28;12(10):2963. doi: 10.3390/nu12102963.
  7. Birari L, Wagh S, Patil KR, Mahajan UB, Unger B, Belemkar S, Goyal SN, Ojha S, Patil CR. Aloin alleviates doxorubicin-induced cardiotoxicity in rats by abrogating oxidative stress and pro-inflammatory cytokines. Cancer Chemother Pharmacol. 2020 Sep;86(3):419-426. doi: 10.1007/s00280-020-04125-w.
  8. Agrawal YO, Mahajan UB, Mahajan HS, Ojha S. Methotrexate-Loaded Nanostructured Lipid Carrier Gel Alleviates Imiquimod-Induced Psoriasis by Moderating Inflammation: Formulation, Optimization, Characterization, In-Vitro and In-Vivo Studies. Int J Nanomedicine. 2020 Jul 7;15:4763-4778. doi: 10.2147/IJN.S247007.
  9. Eissa N, Azimullah S, Jayaprakash P, Jayaraj RL, Reiner D, Ojha S, Beiram R, Stark H, Łażewska D, Kieć-Kononowicz K, Sadek B. The Dual-Active Histamine H3Receptor Antagonist and Acetylcholine Esterase Inhibitor E100 Alleviates Autistic-Like Behaviors and Oxidative Stress in Valproic Acid Induced Autism in Mice. Int J Mol Sci. 2020 Jun 3;21(11):3996. doi: 10.3390/ijms21113996.
  10. Alachkar A, Azimullah S, Lotfy M, Adeghate E, Ojha S, Beiram R, Łażewska D, Kieć-Kononowicz K, Sadek B. Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats. Molecules. 2020 Mar 30;25(7):1575. doi: 10.3390/molecules25071575.
  11. Nauman J, Soteriades ES, Hashim MJ, Govender R, Al Darmaki RS, Al Falasi RJ, Ojha S, Masood-Husain S, Javaid SF, Khan MA. Global Incidence and Mortality Trends due to Adverse Effects of Medical Treatment, 1990-2017: A Systematic Analysis from the Global Burden of Diseases, Injuries and Risk Factors Study. Cureus. 2020 Mar 14;12(3):e7265. doi: 10.7759/cureus.7265.
  12. Birari LA, Mahajan UB, Patil KR, Patil DD, Bagul NA, Belemkar S, Goyal SN, Ojha S, Patil CR. Aloin protects against arsenic trioxide-induced myocardial membrane damage and release of inflammatory cytokines. Naunyn Schmiedebergs Arch Pharmacol. 2020 Aug;393(8):1365-1372. doi: 10.1007/s00210-020-01833-1.
  13. Venkataraman B, Ojha S, Belur PD, Bhongade B, Raj V, Collin PD, Adrian TE, Subramanya SB. Phytochemical drug candidates for the modulation of peroxisome proliferator-activated receptor γ in inflammatory bowel diseases. Phytother Res. 2020 Jul;34(7):1530-1549. doi: 10.1002/ptr.6625. Epub 2020 Feb 3.
  14. Alachkar A, Ojha S, Sadeq A, Adem A, Frank A, Stark H, Sadek B. Experimental Models for the Discovery of Novel Anticonvulsant Drugs: Focus on Pentylenetetrazole-Induced Seizures and Associated Memory Deficits. Curr Pharm Des. 2020;26(15):1693-1711. doi: 10.2174/1381612826666200131105324.
  15. Nagoor Meeran MF , Azimullah S , Laham F , Tariq S , Goyal SN , Adeghate E , Ojha S . α-Bisabolol protects against β-adrenergic agonist-induced myocardial infarction in rats by attenuating inflammation, lysosomal dysfunction, NLRP3 inflammasome activation and modulating autophagic flux. Food Funct. 2020 Jan 29;11(1):965-976. doi: 10.1039/c9fo00530g.
  16. Elarabi HF, Hasan N, Marsden J, Radwan D, Adem A, Almamari S, Elrasheed A. Therapeutic Drug Monitoring in Buprenorphine/Naloxone Treatment for Opioid Use Disorder: Clinical Feasibility and Optimizing Assay Precision. Pharmacopsychiatry. 2020 Apr;53(3):115-121.
  17. Ismail L, Materwala H, Karduck AP, Adem A. Requirements of Health Data Management Systems for Biomedical Care and Research: Scoping Review. J Med Internet Res. 2020 Jul 7;22(7):e17508. doi: 10.2196/17508.
  18. Behl S, Adem A, Hussain A, Singh J. Effect of the anti-retroviral drug, rilpivirine, on human subcutaneous adipose cells and its nutritional management using quercetin. Mol Cell Biochem. 2020 Aug;471(1-2):1-13.
  19. AlNeyadi SS, Amir N, Ghattas MA, Atatreh N, Alketbi SS, Ajeil RA, Adem A. Controlled Release of Pyrimidine Compound Using Polymeric Coated ZIF-8 Metal-Organic Framework as Glucagon-Like Peptide-1 Receptor Agonist Carrier. Molecules. 2020 Sep 20;25(18):E4313.
  20. Islam AUS, Hellman B, Nyberg F, Amir N, Jayaraj RL, Petroianu G, Adem A. Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model. Molecules. 2020 Sep 30;25(19):E4492.
  21. Mahmoud A. Ali , Hassan Abu Damir, Osman M. Ali, Naheed Amir, Saeed Tariq, Michael P. Greenwood, Panjiao Lin, Benjamin Gillard, David Murphy and Abdu Adem. The effect of long-term dehydration and subsequent rehydration on markers of inflammation, oxidative stress and apoptosis in the camel kidney. BMC Veterinary Research, In press,2020. doi.org/10.1186/s12917-020-02628-5.
  22. Al-Dirbashi OY, Sharma C, Al Dahouri N, Al Aidaros A, Al-Muhairi S, Beiram R,Gariballa S, Al Kaabi J. Role of Functional Biomarkers to Identify Early Vitamin B12 Deficiency in Patients with Sleeve Gastrectomy: A Cross-Sectional Study. Medicina (Kaunas). 2020 Mar 20;56(3):142.
  23. JayarajRL, Azimullah S, Beiram R*. Diabetes as a risk factor for Alzheimer's disease in the Middle East and its shared pathological mediators. Saudi J Biol Sci. 2020 Feb;27(2):736-750.
  24. Sadeq A, Alkhidir IY, Aburuz S, Mellal AA, Al Najjar MS, Elnour AA. Risk factors for hospital readmission of patients with heart failure: A cohort study. Pharm Bioallied Sci. 2020 12:335-343.
  25. AbuRuz S, Jaber D, Basheti I, Sadeq A, Arafat M, AlAhmad M, Said A. Impact of pharmacist interventions on drug-related problems in general surgery patients: a randomised controlled trial European Journal of Hospital Pharmacy, 2020.
  26. Aburuz S, Jaber D, AlAhmad M, Basheti I, Arafat M, Sadeq A, Said A. Drug-related problems and the value of a pharmaceutical care service in general surgery patients. International Journal of Clinical Pharmacy. 2020, 42: 817-817.
  27. Arafat M, Fahelelbom KM, Sarfraz MK, Bostanudin MF, Sharif Q, Esmaeil A, AL Hanbali OA, Aburuz S. Comparison between branded and generic furosemide 40 mg tablets using thermal gravimetric analysis and Fourier transform infrared spectroscopy. Pharm Bioallied Sci. 2020, 12: 489-498.
  28. Stip E, Rizvi TA,  Javaid S, Aburuz S, Ahmed NN,  Abdel Aziz K,  Arnone D,  Subbarayan A,  Al Mugaddam F, and Khan G. The Large action of Chlorpromazine: Translational and Transdisciplinary Considerations in the Face of COVID-19. Frontiers in Pharmacology | doi: 10.3389/fphar.2020. 577678.
  29. Kappes L, Amer RL, Sommerlatte S, Bashir G, Plattfaut C, Gieseler F, Gemoll T, Busch H, Altahrawi A, Al-Sbiei A, Haneefa SM, Arafat K, Schimke LF, Khawanky NE, Schulze-Forster K, Heidecke H, Kerstein-Staehle A, Marschner G, Pitann S, Ochs HD, Mueller A, Attoub S, Fernandez-Cabezudo MJ, Riemekasten G, Al-Ramadi BK, Cabral-Marques O. Ambrisentan, an endothelin receptor type A-selective antagonist, inhibits cancer cell migration, invasion, and metastasis. Sci Rep. 2020 Sep 28; 10(1):15931. doi: 10.1038/s41598-020-72960-1.
  30. Al-Sadik H, Sugathan S, Saseedharan P, Sulaiman S, Beegam S, Nemmar A, Attoub S, Karam SM. Effects of Diesel Exhaust Particles on Mouse Gastric Stem Cells. Life (Basel). 2020 Aug 12; 10(8):E149. doi: 10.3390/life10080149.
  31. Raj V, Venkataraman B, Almarzooqi S, Chandran S, Ojha SK, Attoub S, Adrian TE, Subramanya SB. Nerolidol Mitigates Colonic Inflammation: An Experimental Study Using both In Vivo and In Vitro Models. Nutrients. 2020; 12(7):E2032. doi: 10.3390/nu12072032.
  32. Conlon JM, Attoub S, Musale V, Leprince J, Casewell NR, Sanz L, Calvete JJ. Isolation and characterization of cytotoxic and insulin-releasing components from the venom of the black-necked spitting cobra Naja nigricollis (Elapidae). Toxicon X. 2020; 6:100030. doi: 10.1016/j.toxcx.2020.100030.
  33. Eissa N, Jayaprakash P, Stark H, Łażewska D, Kieć-Kononowicz K, Sadek B. Simultaneous Blockade of Histamine H3 Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-like Behaviors in BTBR T+ tf/J Mouse Model of Autism. Biomolecules 2020; 10(9), 1251.
  34. Łażewska D, Bajda M, Kaleta M, Zaręba P, Doroz-Płonka A, Siwek A, Alachkar A, Mogilski S, Saad Ali, Kuder K, Olejarz-Maciej A, Godyń J, Stary D, Więcek M, Sadek B, Malawska B, Kononowicz KK. Rational design of new multitarget histamine H3 receptor ligands as potential candidates for treatment of Alzheimer’s Disease. Eur J Med Chem. 2020;207.
  35. Eissa N, Sadeq A, Sasse A, Sadek B. Role of neuroinflammation in autism spectrum disorder and the emergence of brain histaminergic system. Lessons also for BPSD? Front. Pharmacol. 2020; 11:833.
  1. Adem A, Madjid N, Stiedl O, Bonito-Oliva A, Konradsson-Geuken Å, Holst S, Fisone G, Ögren SO. Atypical but not typical antipsychotic drugs ameliorate phencyclidine-induced emotional memory impairments in mice. Eur Neuropsychopharmacol. 2019 May;29(5):616-628.
  2. Al Rawashdah S, Hamrouni A, Sadek B, Amer R, Metwaly M, Atatreh N, Ghattas MA. Molecular modelling studies on ɑ7 nicotinic receptor 2 allosteric modulators yields novel filter-based virtual screening protocol. J Mol Graph Model 2019; 92:44-54.
  3. Alachkar A, Khan N, Łażewska D, Kieć-Kononowicz K, *Sadek B. Histamine H3 antagonist E177 attenuates amnesia induced by dizocilpine without modulation of anxiety-like behaviors in rats. Neuropsychiatr Dis Treat 2019;15:531-542.
  4. Alsamri H, El Hasasna H, Al Dhaheri Y, Eid AH, Attoub S, Iratni R. Carnosol, a Natural Polyphenol, Inhibits Migration, Metastasis, and Tumor Growth of Breast Cancer via a ROS-Dependent Proteasome Degradation of STAT3. Front Oncol. 2019 Aug 8; 9:743. IF: 4,029
  5. Al-Taee H, Azimullah S, Meeran MFN, Alaraj Almheiri MK, Al Jasmi RA, Tariq S, AB Khan M, Adeghate E, Ojha S. β-caryophyllene, a dietary phytocannabinoids attenuates oxidative stress, inflammation, apoptosis and prevents structural alterations of the myocardium against doxorubicin-induced acute cardiotoxicity in rats: An in vitro and in vivo study. Eur J Pharmacol. 2019 Sep 5;858:172467.
  6. Aryappalli P, Shabbiri K, Masad RJ, Al-Marri RH, Haneefa SM, Mohamed YA, Arafat K, Attoub S, Cabral-Marques O, Ramadi KB, Fernandez-Cabezudo MJ, Al-Ramadi BK. Inhibition of Tyrosine-Phosphorylated STAT3 in Human Breast and Lung Cancer Cells by Manuka Honey is Mediated by Selective Antagonism of the IL-6 Receptor. Int J Mol Sci. 2019 Sep 5; 20(18). IF: 4, 183
  7. Bastaki SMA, Amir N, Więcek M, Kieć-Kononowicz K, *Sadek B. Influence of the novel histamine H3 receptor antagonist/inverse agonist M39 on gastroprotection and PGE2 production induced by (R)-alpha-methylhistamine in C57BL/6 mice. Front. Pharmacol. 2019. In Press.
  8. Behl S, Adem A, Hussain A, Singh J. Effects of rilpivirine, 17β-estradiol and β-naphthoflavone on the inflammatory status of release of adipocytokines in 3T3-L1 adipocytes in vitro. Mol Biol Rep. 2019 Jun;46(3):2643-2655.
  9. Eissa N, Azimullah S, Jayaprakash P, Jayaraj RL, Reiner D, Ojha SK, Beiram R, Stark H, Łażewska D, Kieć-Kononowicz K, *Sadek B. The dual-active histamine H3 receptor antagonist and acetylcholine esterase inhibitor E100 ameliorates stereotyped repetitive behavior and neuroinflammmation in sodium valproate induced autism in mice. Chem Biol Interact 2019; 312:108775.
  10. Elarabi H, Elrasheed A, Ali A, Shawky M, Hasan N, Gawad TA, Adem A, Marsden J.Suboxone Treatment and Recovery Trial (STAR-T): Study Protocol for a Randomised Controlled Trial of Opioid Medication Assisted Treatment with Adjunctive Medication Management Using Therapeutic Drug Monitoring and Contingency Management. J Addict. 2019 Mar 5;2019:2491063.
  11. Javed H, Azimullah S, Meeran MFN, Ansari SA, Ojha S. Neuroprotective Effects of Thymol, a Dietary Monoterpene Against Dopaminergic Neurodegeneration in Rotenone-Induced Rat Model of Parkinson's Disease. International Journal of Molecular Sciences 2019 Mar 27;20(7). pii: E1538. doi: 10.3390/ijms20071538. article
  12. Khairnar SI, Mahajan UB, Patil KR, Patel HM, Shinde SD, Goyal SN, Belemkar S, Ojha S, Patil CR. Disulfiram and its copper chelate attenuate cisplatin-induced acute nephrotoxicity in rats via reduction of oxidative stress and inflammation. Biological and Trace Elements Research 2019 Mar 1. doi: 10.1007/s12011-019-01683-w.
  13. Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson's Disease. Jayaraj RL, Beiram R, Azimullah S, Meeran MFN, Ojha SK, Adem A, Jalal FY. Molecules, 2019 Jun 10;24(11). pii: E2182. doi: 10.3390
  14. Meeran MFN, Al Taee H, Azimullah S, Tariq S, Adeghate E, Ojha S. β-Caryophyllene, a natural bicyclic sesquiterpene attenuates doxorubicin-induced chronic cardiotoxicity via activation of myocardial cannabinoid type-2 (CB(2) receptors in rats. Chemico Biological Interactions 2019 May 1;304:158-167.
  15. Nagoor MF, Shreesh Ojha. Protective effects of thymol against neurodegeneration in a rat model of rotenone-induced Parkinson's disease. Cellular Physiology and Biochemistry, 2019, in the press. target α-synuclein aggregation in Parkinson's disease models. Frontiers in Pharmacology 2019. doi: 10.3389/fphar.2018.01555.
  16. Pantic J, Guilhaudis L, Musale V, Attoub S, Lukic ML, Mechkarska M, Conlon JM. Immunomodulatory, insulinotropic, and cytotoxic activities of phylloseptins and plasticin-TR from the Trinidanian leaf frog Phyllomedusa trinitatis. J Pept Sci. 2019, e3153. IF: 1.969
  17. Patil AS, Singh AD, Mahajan UB, Patil CR, Ojha S, Goyal SN. Protective effect of omeprazole and lansoprazole on β-receptor stimulated myocardial infarction in Wistar rats. Mol Cell Biochem. 2019 Jun;456(1-2):105-113. doi:10.1007/s11010-019-03494-y.
  18. Patil KR, Mahajan UB, Unger BS, Goyal SN, Belemkar S, Surana SJ, Ojha S, Patil CR. Animal Models of Inflammation for screening of anti-inflammatory drugs: implications for the discovery and development of phytopharmaceuticals. International Journal of Molecular Sciences 2019 Sep 5;20(18). pii: E4367.
  19. Salim M. A. Bastaki 1, Naheed Amir 1, Małgorzata Wiecek 2, Katarzyna Kiec´ -Kononowicz 2 and Bassem Sadek. Influence of the Novel Histamine H3 Receptor Antagonist/Inverse Agonist M39 on Gastroprotection and PGE2 Production Induced by (R)-Alpha- Methylhistamine in C57BL/6 Mice. Frontiers in Pharmaoclogy, 2019. (First and Co-corresponding author).
  1. Abdulrazzaq YM, Shafiullah M, Kochyil J, Padmanabhan R, Bastaki SMA. Ameliorative effects of supplemental folinic acid on lamotrigine-induced fetal malformations in the mouse. Mol Cell Biochem, 2018; doi: 10.1007/s11010-018-3285-0. (IF=2.56).
  2. Al Ahmad M, Al Natour A, Attoub S, and H. Hassan A. Monitoring of the Budding Yeast Cell Cycle Using Electrical Parameters. IEEE. 2018, IF: 3.244
  3. Alachkar A, Latacz G, Siwek A, Lubelska A, Honkisz E, Gryboś A, Lazewska D, Handzlik J, Stark H, Kiec-Kononowicz K, *Sadek B. Anticonvulsant evaluation of novel non-imidazole histamine H3R antagonists in different convulsion models in rats. Pharmacol Biochem Behav. 2018; 170:14-24.
  4. Alachkar A, Łażewska D, Latacz G, Frank A, Siwek A, Lubelska A, Honkisz-Orzechowska E, Handzlik J, Stark H, Kieć-Kononowicz K, *Sadek B. Studies on anticonvulsant effects novel histamine H3R antagonists in electrically and chemically induced seizures in rats. Int. J. Mol. Sci. 2018; 19(11), 3386.
  5. Al-Ahmad MM, Amir N, Dhanasekaran S, John A, Abdulrazzaq YM, Ali BR, Bastaki SMA. Genetic polymorphisms of cytochrome P450-1A2 (CYP1A2) among Emiratis. PLoSOne. 2017 Sep 21;12(9):e0183424. doi: 10.1371/journal.pone.0183424. eCollection2017. PubMed PMID: 28934216; PubMed Central PMCID: PMC5608188. (IF=2.80)
  6. Ali MA, Damir HA, Amir N, Adeghate EA, Bastaki S, Murphy D, Adem A. Effects of long-term dehydration on oxidative stress, apoptotic markers and neuropeptides in the gastric mucosa of the dromedary camel Mol Cell Biochem 2018, Nov 26.
  7. Arafat K, Al Kubaisy E, Sulaiman S, Karam S.M, Al Natour A, Hassan A.H, Attoub S. SMARCAD1 in breast cancer progression. Cell Physiol Biochem J. 2018, 50(2):489-500. IF: 5.104
  8. Attoub S, Arafat K, Khalaf T, Sulaiman S, Iratni R. Frondoside A Enhances the Anti-Cancer Effects of Oxaliplatin and 5-Fluorouracil on Colon Cancer Cells. Nutrients. 2018, 10:22-28. IF: 4.196
  9. Bastaki SM, Abdulrazzaq YM, Shafiullah M, Więcek M, Kieć-Kononowicz K, *Sadek B. Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice. Drug Des Devel Ther. 2018; 12:179-194.
  10. Bastaki SMA Padol IT, Amir N, Hunt RH. Effect of aspirin and ibuprofen either alone or in combination on gastric mucosa and bleeding time and on serum prostaglandin E2 and thromboxane A2 levels inn the anaesthetized rats in vivo. Mol Cell Biochem, 2018, 1-10. (IF=2.56)
  11. Bastaki SMA, Adeghate E, Amir N, Ojha S, Oz M. Menthol inhibits Oxidative stress and inflammation in acetic acid-induced colitis in rat colonic mucosa. Am J Trans Res, 2018, (IF=3.061). (First and Corresponding Author)
  12. Eissa N, Al-Houqani M, Sadeq A, Ojha SK, Sasse A, *Sadek B. Current enlightenment about etiology and Pharmacological Treatment of Autism Spectrum Disorder. Front Neurosci. 2018; 12:304.
  13. Eissa N, Jayaprakash P, Azimullah S, Ojha SK, Al-Houqani M, Jalal FY, Łażewska D, Kieć-Kononowicz K, *Sadek B. The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism. Sci Rep. 2018; 8(1):13077.
  14. Eissa N, Khan N, Ojha SK, Łażewska D, Kieć-Kononowicz K, *Sadek B. The histamine H3 receptor antagonist DL77 ameliorates MK801-induced memory deficits in rats. Front Neurosci. 2018; 12:42.
  15. Hammad FT, Ojha S, Azimullah S, Lubbad L. Does β-caryophyllene protect against renal dysfunction following ischemia-reperfusion injury in the rat? Internation Journal of Physiology, Pathophysiology and Pharmacology 2018 Dec 25;10(6):163-171.
  16. Hu X, Rajesh M, Zhang J, Zhou S, Wang S, Sun J, Tan Y, Zheng Y, Cai L. Protection by dimethyl fumarate against diabetic cardiomyopathy in type 1 diabetic mice likely via activation of nuclear factor erythroid-2 related factor 2. Toxicol Lett. 2018 May 1;287:131-141. doi: 10.1016/j.toxlet.2018.01.020. Epub 2018 Feb 3.
  17. Kalász H, Ojha S, Tekes K, Szőke É, Mohanraj R, Fahim M, Adeghate E, Adem A. Pharmacognostical Sources of Popular Medicine To Treat Alzheimer's Disease. Open Med Chem J. 2018 Feb 16;12:23-35. doi: 10.2174/1874104501812010023. eCollection 2018.
  18. Kalász H, Ojha S, Tekes K, Szőke É, Mohanraj R, Fahim M, Adeghate E, Adem A. Pharmacognostical Sources of Popular Medicine to Treat Alzheimer's Disease Open Med Chem J. 2018 Feb 16;12:23-35.
  19. Kurdi A, Hassan K, Venkataraman B, Rajesh M. Nootkatone confers hepatoprotective and anti-fibrotic actions in a murine model of liver fibrosis by suppressing oxidative stress, inflammation, and apoptosis. J Biochem Mol Toxicol. 2018 Feb;32(2). doi: 10.1002/jbt.22017. Epub 2017 Dec 7.
  20. Mahajan UB, Patil PD, Chandrayan G, Patil CR, Agrawal YO, Shreesh Ojha, Goyal SN. Eplerenone pretreatment protects the myocardium against ischaemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway in diabetic rats. Molecular and Cellular Biochemistry 2018 Sep;446(1-2):91-103.
  21. Meeran MFN, Laham F, Al-Taee H, Azimullah S, Shreesh Ojha. Protective effects of α-bisabolol on altered hemodynamics, lipid peroxidation, and nonenzymatic antioxidants in isoproterenol-induced myocardial infarction: in vivo and in vitro evidences. Journal of Biochemical and Molecular Toxicology 2018 Aug 8: e22200.
  22. Nagoor Meeran MF, Goyal SN, Suchal K, Sharma C, Patil CR, Shreesh Ojha. Pharmacological properties, molecular mechanisms, and pharmaceutical development of asiatic acid: a pentacyclic triterpenoid of therapeutic promise. Frontiers in Pharmacology 2018 Sep 4; 9:892.
  23. Nagoor MF, Laham F, Azimullah S, Tariq S, Shreesh Ojha. α-Bisabolol abrogates isoproterenol-induced myocardial infarction by inhibiting mitochondrial dysfunction and intrinsic pathway of apoptosis in rats. Molecular and Cellular Biochemistry 2018 Aug 29.
  24. SB Subramanya, B Venkataraman, MFN Meeran, SN Goyal, CR Patil, Shreesh Ojha. Therapeutic potential of plants and plant derived phytochemicals against acetaminophen-induced liver injury: evidence from preclinical studies. International Journal of Molecular Sciences 2018 Nov 28;19(12). pii: E3776. doi: 10.3390/ijms19123776.
  25. Shanmugam K, Ravindran S, Kurian GA, Rajesh M. Fisetin Confers Cardioprotection against Myocardial Ischemia Reperfusion Injury by Suppressing Mitochondrial Oxidative Stress and Mitochondrial Dysfunction and Inhibiting Glycogen Synthase Kinase 3β Activity. Oxid Med Cell Longev. 2018 Feb 25;2018:9173436. doi: 10.1155/2018/9173436. eCollection 2018.
  26. Shanmugam MK, Shen H, Tang FR, Arfuso F, Rajesh M, Wang L, Kumar AP, Bian J, Goh BC, Bishayee A, Sethi G. Potential role of genipin in cancer therapy. Pharmacol Res. 2018 Jul;133:195-200. doi: 10.1016/j.phrs.2018.05.007. Epub 2018 May 24. Review.
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  1. Adem A, Madjid N, Kahl U, Holst S, Sadek B, Sandin J, Terenius L, Ögren SO. Nociceptin and the NOP receptor in aversive learning in mice. Eur Neuropsychopharmacol.2017; In Press.
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  20. Nurulain SM, Ojha S, Tekes K, Shafiullah M, Kalasz H, Adem A. (2015). Efficacy of N-acetylcysteine, glutathione, and ascorbic acid in acute toxicity of paraoxon to Wistar rats: survival study. Oxid Med Cell Longev, 2015:329306. doi:10.1155/2015/329306. PubMed PMID: 26167240.
  21. Ojha S, Azimullah S, Mohanraj R, Sharma C, Yasin J, Arya DS, Adem A. (2015). Thymoquinone Protects against Myocardial Ischemic Injury by Mitigating Oxidative Stress and Inflammation. Evid Based Complement Alternat Med, 2015:143629. doi: 10.1155/2015/143629. PubMed PMID: 26101531.
  22. Ojha S, Javed H, Azimullah S, Abul Khair SB, Haque ME. (2015). Neuroprotective potential of ferulic acid in the rotenone model of Parkinson's disease. Drug Des Devel Ther, Oct 7; 9:5499-510. doi: 10.2147/DDDT.S90616. eCollection 2015. PubMed PMID: 26504373; PubMed Central PMCID: PMC4603721.
  23. Ojha SK, Sharma C, Golechha MJ, Bhatia J, Kumari S, Arya DS. (2015). Licorice treatment prevents oxidative stress, restores cardiac function, and salvages myocardium in rat model of myocardial injury. Toxicol Ind Health, 31(2):140-52. doi: 10.1177/0748233713491800. PubMed PMID: 23771872.
  24. Onopchenko OV, Kosiakova GV, Oz M, Klimashevsky VM, Gula NM. (2015). N-stearoylethanolamine restores pancreas lipid composition in obesity-induced insulin resistant rats. Lipids, 50(1):13-21. doi: 10.1007/s11745-014-3960-1. Epub 2014 Oct 15. PubMed PMID: 25314940.
  25. Oz M, Lozon Y, Sultan A, Yang KH, Galadari S. (2015). Effects of monoterpenes on ion channels of excitable cells. Pharmacol Ther, 152:83-97. doi:10.1016/j. pharmthera.2015.05.006. PubMed PMID: 25956464.
  26. Patil KR, Mohapatra P, Patel HM, Goyal SN, Ojha S, Kundu CN, Patil CR. (2015). Pentacyclic triterpenoids inhibit IKKβ mediated activation of NF-κB pathway: in silico and in vitro evidences. PLoS One, 10(5):e0125709. doi:10.1371/ journal.pone.0125709. eCollection 2015. PubMed PMID: 25938234.
  27. Reddy NM, Mahajan UB, Patil CR, Agrawal YO, Ojha S, Goyal SN. (2015). Eplerenone attenuates cardiac dysfunction and oxidative stress in β-receptor stimulated myocardial infarcted rats. Am J Transl Res, 7(9):1602-11. eCollection 2015. PubMed PMID: 26550459.
  28. Sadek B, Khanian SS, Ashoor A, Prytkova T, Ghattas MA, Atatreh N, Nurulain SM, Yang KH, Howarth FC, Oz M. (2015). Effects of antihistamines on the function of human α7-nicotinic acetylcholine receptors. Eur J Pharmacol, 746:308-16. doi: 10.1016/j.ejphar.2014.10.046. PubMed PMID: 25445036.
  29. Sharma C, Sadek B, Goyal SN, Sinha S, Kamal MA, Ojha S. (2015). Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development. Evid Based Complement Alternat Med, 2015:238482. doi: 10.1155/2015/238482. PubMed PMID: 26664449.
  30. Zadjali SA, Nemmar A, Fahim MA, Azimullah S, Subramanian D, Yasin J, Amir N, Hasan MY, Adem A. (2015). Lead exposure causes thyroid abnormalities in diabetic rats. (2015). Int J Clin Exp Med. 8(5):7160-7. eCollection 2015. PubMed PMID: 26221254.
  31. Bastaki SMA, Zaabi A, Amir N, Adeghate E. (2015). Effect of turmeric on serum and colonic mucosa levels of glutathione, myeloperoxidase3, and IL-23 in acetic acid-induced inflammatory bowel disease in rats. J Gastroenterol Hepatol, 30 (suppl, 4) 28-159.

Faculty

Note: If calling from outside the UAEU organization, dial (+971 3 713) before the extension.

Name Position Email Extension
Prof. Samir Attoub Professor and Chair samir.attoub@uaeu.ac.ae 7219
Prof. Bassem S. Sadek Professor bassem.sadek@uaeu.ac.ae 7512
Prof. Salahdein Aburuz Professor saburuz@uaeu.ac.ae 7665
Dr. Shreesh K. Ojha Professor shreeshojha@uaeu.ac.ae 7524
Dr. Amal Akour Associate Professor aakour@uaeu.ac.ae 7542
Dr. Rami A. Beiram Assistant Professor and Assistant Dean  rbeiram@uaeu.ac.ae 7656
Ms. Cham Zain AlAbdin Instructor sham.zain@uaeu.ac.ae 7526

Staff

Note: If calling from outside the UAEU organization, dial (+971 3 713) before the extension.

Name Position Email Extension
Mr. Amar Maghoub Animal Nurture Technician amar.omer@uaeu.ac.ae 7652
Azim Ullah Shamsulislam  Laboratory Specialist azim.sheikh@uaeu.ac.ae 7531
Ms. Kholoud F. Arafat Medical Research Specialist I kholoud.arafat@uaeu.ac.ae 7611
Ms. Khuloud K. Al Kaabi Administrator I k.kaabi@uaeu.ac.ae 7521
Ms. Petrilla Jayaprakash Medical Research Specialist I petrilla.jp@uaeu.ac.ae 7634
Ms. Priya D. Yuvaraju Medical Research Specialist I priyay@uaeu.ac.ae 7617

General Enquiries

Thank you for your interest in the Pharmacology and Therapeutics Department. We welcome your query and encourage you to contact us using the information below:

United Arab Emirates University,
College of Medicine and Health Sciences
P.O.Box: 17666, Al Ain, UAE

Phone: +971 3 7137 521

United Arab Emirates University (UAEU) - Best University in Abu Dhabi, UAE

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