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Department of Physiology

Overview

The Department of Physiology contributes to teaching in the first two years (Premedical Sciences Course) and the third and fourth years of the medical curriculum (Preclinical Sciences Course). The Department also contributes to the Bachelor of Medical Science and makes substantial contributions to the post-graduate Masters and PhD programs in Biomedical Sciences. The research interests of the Department include diabetes and the cardiovascular system, calcium signalling in excitable cells, neuroscience, gastrointestinal and uterine electrophysiology, cancer and air pollution.

Teaching

  • Premedical: During the premedical sciences course the Department of Physiology teaches the basic principles of human physiology beginning with a general introduction to human physiology and continuing with introductions to the physiology of the cardiovascular, respiratory systems, gastrointestinal, renal, endocrine and nervous system and integrative physiology.
  • Preclinical: During the preclinical sciences course the Department of Physiology contributes classes in haematology and mechanisms of malignancy, cardiovascular, respiratory, renal and urogenital, gastrointestinal, endocrine and metabolism, musculoskeletal and neurosciences and special senses modules.
  • Bachelor of Medical Sciences: The premedical sciences course forms the basis for the first two years of the program and this is followed by a selection of biomedical courses. The Department of Physiology’s contribution includes advanced haematology, cardiovascular, respiration, renal, endocrine, exercise and environmental physiology.
  • Teaching modalities include lectures, problem based learning, computer based learning, team based learning and practical classes.

The Department of Physiology also contributes a range of courses to the post-graduate Masters and PhD program including a variety of advanced physiology courses and some more specialized courses in various fields including cancer biology and advanced electrophysiology.

 

Publications

  1. Ljubisavljevic MR, Oommen J, Filipovic S, Bjekic J, Szolics M, Nagelkerke N. Effects of tDCS of Dorsolateral Prefrontal Cortex on Dual-Task Performance Involving Manual Dexterity and Cognitive Task in Healthy Older Adults. Front Aging Neurosci. 2019 Jun 18;11:144.doi: 10.3389/fnagi.2019.00144. eCollection 2019. PubMed PMID: 31275139; PubMed Central PMCID: PMC6592113. 10.1016/j.brainres.2018.01.034. Epub 2018 Feb 5.
  2. Shehab S, D'souza C, Ljubisavljevic M, Redgrave P.  Activation of the subthalamic nucleus suppressed by high frequency stimulation: A c-Fos immunohistochemical study. Brain Res. 2018 Apr;1685:42-50. doi: 10.1016/j.brainres.2018.01.034. Epub 2018 Feb 5. PubMed PMID: 29421187.
  3. Kačar A, Milanović SD, Filipović SR, Ljubisavljević MR. Changes in cortical excitability during paired associative stimulation in Parkinson's disease patients and healthy subjects. Neurosci Res. 2017 Nov;124:51-56.doi: 10.1016/j.neures.2017.06.001. Epub 2017 Jun 9. PubMed PMID: 28606723.
  4. Ljubisavljevic M, Maxood K, Bjekic J, Oommen J, Nagelkerke N. Long-Term Effects of Repeated Prefrontal Cortex Transcranial Direct Current Stimulation (tDCS) on Food Craving in Normal and Overweight Young Adults. Brain Stimul. 2016 Nov - Dec;9(6):826-833.doi: 10.1016/j.brs.2016.07.002. Epub 2016 Jul 15. PubMed PMID:27498606.
  5. Ljubisavljevic MR, Javid A, Oommen J, Parekh K, Nagelkerke N, Shehab S, Adrian TE. The Effects of Different Repetitive Transcranial Magnetic Stimulation (rTMS) Protocols on Cortical Gene Expression in a Rat Model of CerebralIschemic-Reperfusion Injury. PLoS One. 2015 Oct 2;10(10):e0139892. doi:10.1371/journal.pone.0139892. eCollection 2015. PubMed PMID:26431529; PubMed Central PMCID: PMC4592250.
  6. Shehab S, Anwer M, Galani D, Abdulkarim A, Al-Nuaimi K, Al-Baloushi A, Tariq S, Nagelkerke N, Ljubisavljevic M. Anatomical evidence that the uninjured adjacent L4 nerve plays a significant role in the development of peripheral neuropathic pain after L5 spinal nerve ligation in rats. J Comp Neurol. 2015 Aug 15;523(12):1731-47. doi: 10.1002/cne.23750. Epub 2015 Apr 7. PubMed PMID:25631932.
  7. RAZA H, JOHN A, HOWARTH FC (2015) Increased oxidative stress and mitochondrial dysfunction in Zucker diabetic rat liver and brain, Cellular Physiology and Biochemistry, 35(3):1241-51.doi: 10.1159/000373947. Epub 2015 Feb 11. PMID 25766534. IF 5.5, CiteScore 4.81
  8. AMIRI L, JOHN A, SHAFARIN J, ADEGHATE E,JAYAPRAKASH P, YASIN J, HOWARTH FC, RAZA H (2015) Enhanced glucose tolerance and pancreaticbeta cell function by low dose aspirin in hyperglycemic insulin-resistant type 2 diabetic Goto-Kakizaki (GK) rats, Cellular Physiology Biochemistry, 36(5):1939-1950. IF 5.5, CiteScore 4.81
  9. ZHANG Y, WANG Y, GERGES JY, QURESHI AM, LOGANTHA SJRJ, KASSAB S, BOYETT MR, GARDINER NJ, HOWARTH FC, DOBRZYNSKI H (2019) Electrical conduction systemremodelling in streptozotocin-induced diabetes mellitus rat heart, Frontiers in Physiology, 2019 Jul 8;10:826. doi: 10.3389/fphys.2019.00826. eCollection 2019. IF 4.13
  10. I I Ali, AL-SALAM S, HOWARTH FC, SHMYGOL A (2019) Oxytocin induces intracellular Ca2+ release in cardiac fibroblasts from neonatal rats, Cell calcium, 2019 Oct 4;84:102099.doi: 10.1016/j.ceca.2019.102099. [Epub ahead of print]. IF 4.13, CiteScore 3.54
  11. ALI RM, AL KURY LT, YANG KH, QURESHI A, RAJESH M, GALADARI S, SHUBA YM, HOWARTH FC, OZ M (2015) Effects of cannabidiol on contractions and calcium signaling in rat ventricular myocytes. Cell Calcium, 2015 Apr;57(4):290-9.doi:10.1016/j.ceca.2015.02.001. Epub 2015 Feb 9. PubMed PMID:25711828. IF 4.13, CiteScore 3.54
  12. Nemmar A, Beegam S, Yuvaraju P, Yasin J, Tariq S, Attoub S, Ali BH. Ultrasmall superparamagnetic iron oxide nanoparticles acutely promote thrombosis and cardiac oxidative stress and DNA damage in mice. Part Fibre Toxicol. 2016 Apr 30;13(1):22.doi: 10.1186/s12989-016-0132-x. PubMed PMID:27138375; PubMed Central PMCID: PMC4852430.
  13. Nemmar A, Al-Salam S, Yuvaraju P, Beegam S, Yasin J, Ali BH. Chronic exposure to water-pipe smoke induces cardiovascular dysfunction in mice. Am J Physiol Heart Circ Physiol. 2017 Feb 1;312(2):H329-H339.doi: 10.1152/ajpheart.00450.2016. Epub 2016 Dec 9. PubMed PMID 27940964.
  14. Nemmar A, Al-Salam S, Beegam S, Yuvaraju P, Ali BH. Thrombosis and systemic and cardiac oxidative stress and DNA damage induced by pulmonary exposure to diesel exhaust particles and the effect of nootkatone thereon. Am J Physiol Heart Circ Physiol. 2018 May 1;314(5):H917-H927.doi: 10.1152/ajpheart.00313.2017. Epub 2018 Jan 5. PubMed PMID 29351455.
  15. Nemmar A, Al-Salam S, Yuvaraju P, Beegam S, Ali BH. Exercise Training Mitigates Water Pipe Smoke Exposure-Induced Pulmonary Impairment via Inhibiting NF-κB and Activating Nrf2 Signalling Pathways. Oxid Med Cell Longev. 2018 Mar 6;2018:7459612.doi: 10.1155/2018/7459612. eCollection 2018. PubMed PMID:29692875; PubMed Central PMCID: PMC5859847.
  16. Nemmar A, Al-Salam S, Beegam S, Yuvaraju P, Ali BH. Gum Arabic Ameliorates Impaired Coagulation and Cardiotoxicity Induced by Water-Pipe Smoke Exposure in Mice. Front Physiol. 2019 Feb 25;10:53.doi: 10.3389/fphys.2019.00053. eCollection 2019. PubMed PMID: 30858803; PubMed Central PMCID: PMC6397852.
  17. Parolin Schnekenberg R., Perkins E.M., Miller J.W., Davies W.I., D'Adamo M.C., Pessia M., Németh A.H. (2015). De novo point mutations in patients diagnosed with ataxic cerebral palsy. BRAIN 138(Pt 7):1817-32. doi: 10.1093/brain/awv117. Epub 2015 May 16.
  18. Lanciotti A., Brignone M.S., Visentin S., De Nuccio C., Catacuzzeno L., Mallozzi C., Petrini S., Caramia M., Veroni C., Minnone G., Bernardo A., Franciolini F., Pessia M., Bertini E., Petrucci T.C., Ambrosini E. (2016). Megalencephalic leukoencephalopathy with subcortical cysts protein-1 regulates epidermal growth factor receptor signaling in astrocytes. Hum. Mol. Genet. 25(8):1543-58.doi: 10.1093/hmg/ddw032.
  19. Kaya N., Alsagob M., D’Adamo M.C., Al-Bakheet A., Hasan S., Muccioli M., Almutairi F.B., Almass R., Aldosary M., Monies D., Mustafa O.M., Alyounes B., Kenana R., Al-Zahrani J., Naim E., Binhumaid F.S., Qari A., Almutairi F., Meyer B., Plageman T.F., Pessia M., Colak D., Al-Owain M. (2016). KCNA4 deficiency leads to a syndrome of abnormal striatum, congenital cataractand intellectual disability. J. Med. Genet. August 31, 2016 as 10.1136/jmedgenet-2015-103637.
  20. Sicca F., Ambrosini E., Marchese M., Sforna S., Servettini I., Valvo G., Brignone M.S., Lanciotti A., Moro F., Grottesi A., Catacuzzeno L., Baldini S., D’Adamo M.C., Franciolini F., Molinari P., Santorelli F.M., Pessia M. (2016). Gain-of-function defects of astrocytic Kir4.1 channels in children with autism spectrum disorders and epilepsy. Nature Publishing Group: Scientific Reports 6:34325. doi: 10.1038/srep34325.
  21. Hasan S., Bove C. Silvestri G., Mantuano E., Modoni A., Veneziano L., Macchioni L., Hunter T., Hunter G., Pessia M., D’Adamo M.C. (2017). A channelopathy mutation in the voltage-sensor discloses contributions of a conserved phenylalanine to gating properties of Kv1.1 channels and ataxia. Nature Publishing Group: Scientific Reports 7(1):4583.doi: 10.1038/s41598-017-03041-z.
  22. Romani L., Oikonomou V., Moretti S., Iannitti R.G., D’Adamo M.C., Villella V.R., Pariano M., Sforna L., Borghi M., Bellet M.M., Fallarino F., Pallotta M.T., Servillo G., Ferrari E., Puccetti P., Kroemer G., Pessia M…... Garaci E. (2017). Thymosin α1 represents a potential potent single molecule-based therapy for cystic fibrosis. Nature Medicine 23(5):590-600. doi: 10.1038/nm.4305.
  23. Ali II, Al-Salam S, Howarth FC, Shmygol A, Oxytocin induces intracellular Ca2+ release in cardiac fibroblasts from neonatal rats, Cell Calcium (2019), 84doi: 10.1016/j.ceca.2019.102099.
  24. Testrow CP, Holden AV, Shmygol A, Zhang H. (2018) A computational model of excitation and contraction in uterine myocytes from the pregnant rat. Sci Rep. Jun 14;8(1):9159.doi: 10.1038/s41598-018-27069-x
  25. Muir R, Liu G, Khan R, Shmygol A, Quenby S, Gibson RA, et al. Maternal obesity-induced decreases in plasma, hepatic and uterine polyunsaturated fatty acids duringlabour is reversed through improved nutrition at conception. Sci Rep. 2018;8(1):1–11.
  26. Muir, R., Ballan, Clifford, J., McMullen, S., Khan, R., Shmygol, A., Quenby, S. and Elmes, M. (2016) Modelling maternal obesity: the effects of a chronic high-fat, high-cholesterol diet on uterine expression of contractile-associated proteins and ex vivo contractile activity during labour in the rat. Clinical Science 130, 183–192 doi: 10.1042/CS20150539.
  27. Loftus, F.C., Richardson, M. J. E. and Shmygol, A. (2015) Single-cell mechanics and calciumsignalling in organotypic slices of human myometrium. Journal of Biomechanics, 46 pp 1620.
  28. Hennig R, Albawardi A, Almarzooqi S, Haneefa S, Imbaraj E, Zaaba NE, Nemmar A, Subramanya S, Maruta H, Adrian TE. 1,2,3-Triazolyl ester of ketorolac (15K), a potent PAK1 blocker, inhibits both growth and metastasis of orthotopic human pancreatic cancer xenografts in mice. Drug Discov Ther. 2019 Oct 27. doi:10.5582/ddt.2019.01068. [Epub ahead of print] PubMed PMID:31656252.
  29. Subramanya SB, Venkataraman B, Meeran MFN, Goyal SN, Patil CR, Ojha S. Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver Injury. Int J Mol Sci. 2018 Nov 28;19(12). pii: E3776. doi: 10.3390/ijms19123776. Review. PubMed PMID:30486484; PubMed Central PMCID: PMC6321362.
  30. Subramanya SB, Chandran S, Almarzooqi S, Raj V, Al Zahmi AS, Al Katheeri RA, Al Zadjali SA, Collin PD, Adrian TE. Frondanol, a Nutraceutical Extract from Cucumaria frondosa, Attenuates Colonic Inflammation in a DSS-Induced Colitis Model in Mice. Mar Drugs. 2018 Apr 30;16(5). pii: E148. doi: 10.3390/md16050148. PubMed PMID: 29710854; PubMed Central PMCID: PMC5983279.
  31. Jahan S, Kumar D, Chaturvedi S, Rashid M, Wahajuddin M, Khan YA, Goyal SN, Patil CR, Mohanraj R, Subramanya S, Ojha S. Therapeutic Targeting of NLRP3 Inflammasomes by Natural Products and Pharmaceuticals: A Novel Mechanistic Approach for Inflammatory Diseases. Curr Med Chem. 2017;24(16):1645-1670. doi: 10.2174/0929867324666170227121619. Review. PubMed PMID:28245768.
  32. Subramanya SB, Stephen B, Nair SS, Schäfer KH, Lammers WJ. Effect of Ethanol Exposure on Slow Wave Activity and Smooth Muscle Contraction in the Rat Small Intestine. Dig Dis Sci. 2015 Dec;60(12):3579-89. doi: 10.1007/s10620-015-3813-7. Epub 2015 Jul 24. PubMed PMID 26204976.

  1. Lammers WJEP. (2013). The electrical activities of the uterus during pregnancy. Reproductive Sciences 20(2), 182-189, 2013.
  2. Lammers WJEP. (2013). Arrhythmias in the gut. Neurogastroenterology & Motility, 25, 353-357, 2013.

  1. Kader HMA, Nalin N, El-Zeiry M, Laufer S, Adrian TE. (2013). Effects of a Combined Cyclooxygenase/Lipoxygenase Inhibitor in Pancreatic Cancer. Pancreas, 42:1365.

Faculty

Note: If calling from outside the UAEU organization, dial (+971 3 713) before the extension.

Name Position Email Extension
Prof. Milos Ljubisavljevic Professor and Chair milos@uaeu.ac.ae 7707
Prof. Abderrahim Nemmar Professor anemmar@uaeu.ac.ae 7533
Prof. Anatoliy Shmygol Professor a.shmygol@uaeu.ac.ae 7535
Prof. Frank C. Howarth Professor chris.howarth@uaeu.ac.ae 7536
Prof. Mauro Pessia Professor mauro@uaeu.ac.ae 7352
Dr. Sandeep B. Subramanya Associate Professor sandeep.bs@uaeu.ac.ae 7534
Dr. Abdulla S. Kazim Assistant Professor abdullakazim@uaeu.ac.ae 7523

Staff

Note: If calling from outside the UAEU organization, dial (+971 3 713) before the extension.

Name Position Email Extension
Mr. Muhammad A. Qureshi Medical Research Specialist I anwar.qureshi@uaeu.ac.ae 7612
Ms. Betty S. Stephen Medical Research Specialist I bettys@uaeu.ac.ae 7609
Mr. Gilles Marcel Paul Marie Medical Research Specialist I g_bru-mercier@uaeu.ac.ae 7407
Ms. Sumaya B. Anakkaru Medical Research Specialist I sumayab@uaeu.ac.ae 7610

General Enquiries

Thank you for your interest in the Physiology Department. We welcome your query and encourage you to contact us using the information below:

United Arab Emirates University,
College of Medicine and Health Sciences
P.O.Box: 17666, Al Ain, UAE

Phone: +971 3 7137 537

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Aug 15, 2022